Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics

Chelliapan, Shreeshivadasan; Wilby, Thomas; Sallis, Paul J.

doi:10.1016/j.watres.2005.11.020

Cited by 225 publications

(99 citation statements)

References 24 publications

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“…Aerobic applications include activated sludge, membrane batch reactors and sequence batch reactors (LaPara et al, 2002;Suman Raj and Anjaneyulu, 2005;Noble, 2006;Chang et al, 2008 andChen et al, 2008). Anaerobic methods include anaerobic sludge reactors, anaerobic film reactors and anaerobic filters (Gangagni et al, 2005;Enright et al, 2005;Chelliapan et al, 2006;Oktem et al, 2007;Sreekanth et al, 2009). The wastewater characteristics play a key role in the selection of biological treatments.…”

Section: Conventional Treatment Methodsmentioning

confidence: 99%

“…One way around this is to use anaerobic microorganisms such as methanogenic archaea, which can adapt to levels many times those that inhibit unadapted methanogens (Fountoulakis et al, 2008) as well as incorporating different configurations including biomembrane reactors, stirred tank reactors, up-flow anaerobic filters and fluidised bed reactors (Gangagni Rao et al, 2005;Chelliapan et al, 2006;Oktem et al, 2007). Up-flow anaerobic stage reactors (UASRs) used as a pre-treatment to activated sludge for industrial effluent have been shown to be efficient for the removal of pharmaceuticals even at high concentrations (Chelliapan et al, 2006;Oktem et al, 2007).…”

Section: Pharmaceutical Wastewater Effluentmentioning

confidence: 99%

“…Up-flow anaerobic stage reactors (UASRs) used as a pre-treatment to activated sludge for industrial effluent have been shown to be efficient for the removal of pharmaceuticals even at high concentrations (Chelliapan et al, 2006;Oktem et al, 2007). A UASR fed with real pharmaceutical wastewater containing the antibiotics tylosin and avilamycin showed a high degree of COD and drug removal (Chelliapan et al, 2006).…”

Section: Pharmaceutical Wastewater Effluentmentioning

confidence: 99%

“…Furthermore, pharmaceutical industry wastewaters may contain organic solvents, catalysts, additants, reactants, intermediates, raw materials and APIs (Sreekanth et al, 2009), which makes them difficult to treat. The presence of toxic or recalcitrant substances in such wastewater results in lower Chemical oxygen demand (COD) removal efficiencies (Chelliapan et al, 2006). It has been estimated that up to half of the pharmaceutical wastewater produced worldwide is released without any treatment (Enick and Moore, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Int. J. Environ. Sci. Technol.

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Section: Conventional Treatment Methodsmentioning

confidence: 99%

Section: Pharmaceutical Wastewater Effluentmentioning

confidence: 99%

Section: Pharmaceutical Wastewater Effluentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment options for wastewater effluents from pharmaceutical companies

Deegan

Basha

Nolan

et al. 2011

Int. J. Environ. Sci. Technol.

295

132

View full text Add to dashboard Cite

“…Previous studies of macrolide inhibition in anaerobic systems provide contradictory results, ranging from negligible effects (Camprubi et al, 1988;Chelliapan et al, 2006;Masse et al, 2000;Poels et al, 1984;Stone et al, 2009) to substantial decreases in treatment performance (Amin et al, 2006;Loftin et al, 2005;Sanz et al, 1996;Shimada et al, 2008a). In anaerobic batch tests, the addition of tylosin has inhibited acetate, propionate, and butyrate uptake (Amin et al, 2006;Sanz et al, 1996;Shimada et al, 2008a).…”

Section: Introductionmentioning

confidence: 99%

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Shimada

Zilles

et al. 2010

Biotech & Bioengineering

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Morgenroth, Eberhard; and Raskin, Lutgarde, "Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor" (2010). Civil Engineering Faculty Publications. 37. http://digitalcommons.unl.edu/civilengfacpub/37 AbstractThe effects of the antimicrobial tylosin on a methanogenic microbial community were studied in a glucosefed laboratory-scale anaerobic sequencing batch reactor (ASBR) exposed to stepwise increases of tylosin (0, 1.67, and 167 mg/L). The microbial community structure was determined using quantitative fluorescence in situ hybridization (FISH) and phylogenetic analyses of bacterial 16S ribosomal RNA (rRNA) gene clone libraries of biomass samples. During the periods without tylosin addition and with an influent tylosin concentration of 1.67 mg/L, 16S rRNA gene sequences related to Syntrophobacter were detected and the relative abundance of Methanosaeta species was high. During the highest tylosin dose of 167 mg/L, 16S rRNA gene sequences related to Syntrophobacter species were not detected and the relative abundance of Methanosaeta decreased considerably. Throughout the experimental period, Propionibacteriaceae and high GC Gram-positive bacteria were present, based on 16S rRNA gene sequences and FISH analyses, respectively. The accumulation of propionate and subsequent reactor failure after long-term exposure to tylosin are attributed to the direct inhibition of propionate-oxidizing syntrophic bacteria closely related to Syntrophobacter and the indirect inhibition of Methanosaeta by high propionate concentrations and low pH.

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Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment

Shimada

Zilles

Morgenroth

et al. 2008

Biotech & Bioengineering

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A laboratory-scale anaerobic sequencing batch reactor (ASBR) was operated using a glucose-based synthetic wastewater to study the effects of tylosin, a macrolide antimicrobial commonly used in swine production, on treatment performance. The experimental period was divided into three consecutive phases with different influent tylosin concentrations (0, 1.67, and 167 mg/L). The addition of 1.67 mg/L tylosin to the reactor had negligible effects on the overall treatment performance, that is, total methane production and effluent chemical oxygen demand did not change significantly (P < 0.05), yet analyses of individual ASBR cycles revealed a decrease in the rates of both methane production and propionate uptake after tylosin was added. The addition of 167 mg/L tylosin to the reactor resulted in a gradual decrease in methane production and the accumulation of propionate and acetate. Subsequent inhibition of methanogenesis was attributed to a decrease in the pH of the reactor. After the addition of 167 mg/L tylosin to the reactor, an initial decrease in the rate of glucose uptake during the ASBR cycle followed by a gradual recovery was observed. In batch tests, the specific biogas production with the substrate butyrate was completely inhibited in the presence of tylosin. This study indicated that tylosin inhibited propionate- and butyrate-oxidizing syntrophic bacteria and fermenting bacteria resulting in unfavorable effects on methanogenesis.

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Performance of an up-flow anaerobic stage reactor (UASR) in the treatment of pharmaceutical wastewater containing macrolide antibiotics

Cited by 225 publications

References 24 publications

Treatment options for wastewater effluents from pharmaceutical companies

Treatment options for wastewater effluents from pharmaceutical companies

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment

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