Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Birbrair, Alexander; Zhang, Tan; Wang, Zhongmin; Messi, Marı́a Laura; Mintz, Akiva; Delbono, Osvaldo

doi:10.3389/fnagi.2014.00245

Cited by 114 publications

(91 citation statements)

References 354 publications

(442 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to the association between SC and capillaries, extensive work has demonstrated crosstalk between endothelial cell residing in capillary walls and SC. Pericytes, largely undifferentiated connective tissue cells, are also located within the capillary wall and have been identified as myogenic precursor cells that reside within skeletal muscle but are distinct from SC [49]. Importantly, pericytes become active following injury to skeletal muscle and their transplantation into injured muscle contributes to muscle fibre regeneration in mice [50].…”

Section: Muscle Fibre Vascularization and Impaired Sc Function With Agementioning

confidence: 99%

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

et al. 2016

View full text Add to dashboard Cite

Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan. It is well established that SC are essential in skeletal muscle regeneration, and it has been hypothesized that a reduction and/or dysregulation of the SC pool, may contribute to accelerated loss of skeletal muscle mass that is observed with advancing age. The preservation of skeletal muscle tissue and its ability to respond to stimuli may be impacted by reduced SC content and impaired function observed with aging. Aging is also associated with a reduction in capillarization of skeletal muscle. We have recently demonstrated that the distance between type II fibre-associated SC and capillaries is greater in older compared to younger adults. The greater distance between SC and capillaries in older adults may contribute to the dysregulation in SC activation ultimately impairing muscle's ability to remodel and, in extreme circumstances, regenerate. This viewpoint will highlight the importance of optimal SC activation in addition to skeletal muscle capillarization to maximize the regenerative potential of skeletal muscle in older adults.

show abstract

Section: Muscle Fibre Vascularization and Impaired Sc Function With Agementioning

confidence: 99%

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Interestingly, in the same research glioma stem cells were found to rarely differentiate into ECs. Pericytes can generate ECs, similar to the function of mesenchymal stem cells (MSCs) [81,82]. It is reasonable to suppose that CSC-derived pericytes might be in a "transitional state" during CSC differentiation into ECs, but it requires further investigation to confirm whether there is a relationship between tumor-derived pericytes and ECs.…”

Section: Cscs Contribute To Vascular Niche Reconstruction By Generatimentioning

confidence: 98%

Cancer stem cells and their vascular niche: Do they benefit from each other?

2016

View full text Add to dashboard Cite

“…It is also important to highlight the outstanding role of the epaxial dermomyotome involved in deep paravertebral muscle development under the expression and upregulation of Lbx1 [18][19][20]. It has also become more widely known the role of type 2 perivascular pericytes during the muscular regeneration and primary myogenesis [21].…”

Section: Genetic and Molecular Mechanisms Of Muscular Embryogenesismentioning

confidence: 99%

Normal muscle structure, growth, development, and regeneration

Pinto

Souza

Oliveira

2015

Curr Rev Musculoskelet Med

View full text Add to dashboard Cite

Knowledge about biochemical, structural and physiological aspects, and properties regarding the skeletal muscle has been widely obtained in the last decades. Muscle disorders, mainly represented in neuromuscular clinical practice by acquired and hereditary myopathies, are well-recognized and frequently diagnosed in practice. Most clinical complaints and biochemical characterizations of each myopathy depends on the appropriate knowledge and interpretation of pathological findings and their comparison with normal muscle findings. Great improvement has been obtained in the last decades mainly involving the mechanisms of normal muscle architecture and physiological function in the healthy individuals. Genetic mechanisms have also been widely studied. We provide an extensive literature review involving current knowledge regarding muscle cell structure and function and embryological and regenerative processes linked to muscle lesion. An updated comprehensive description involving the main nuclear genomic regulatory mechanisms of muscle regeneration and embryogenesis is provided in this review.

show abstract

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

Cited by 114 publications

References 354 publications

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization

Cancer stem cells and their vascular niche: Do they benefit from each other?

Normal muscle structure, growth, development, and regeneration

Contact Info

Product

Resources

About