Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats

Kangwan, Napapan; Pratchayasakul, Wasana; Kongkaew, Aphisek; Pintha, Komsak; Chattipakorn, Nipon

doi:10.3390/nu13093141

Cited by 19 publications

(6 citation statements)

References 54 publications

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“…In another study, although fish oil supplementation resulted in lower body weight and lower inflammatory status in both male and female mice fed a high fat diet, the fish oil diet did not correct the low Bacteroidetes-to-Firmicutes ratio elicited by a high fat diet in female mice [57 ▪ ]. An oil high in the short-chain omega-3 fatty acid, α-linolenic acid that is metabolically elongated to form EPA, also was shown to improve high-fat diet induced dysbiosis as defined by alterations in the abundance of Firmicutes and Bacteroidetes [58].…”

Section: Effects Of Dietary Fat Type On the Gut Microbiotamentioning

confidence: 93%

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Djurić¹

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewGiven the world-wide problem of obesity, this review considers what types of dietary changes can be utilized to minimize the adverse effects of an obesogenic diet on the intestinal microbiota.Recent findingsIn rodents fed high-fat diets containing lard or Western blend fats to induce obesity, switching to high-fat diets formulated to contain higher amounts of fiber or fiber-containing foods, plant extracts, omega-3 fatty acids or whole grains has beneficial effects on body weight, metabolic alterations, and the intestinal microbiota. Several studies show that the intestinal microbiota has a role in mediating the beneficial health effects of these dietary factors. Many aspects of the microbiota observed in animals when healthful dietary components were added to the feed have also been observed in humans who follow healthful dietary patterns.SummaryThe data shows that specific foods and macronutrients can normalize the obesity-associated microbiota and improve metabolic health. These findings support the design of dietary interventions that would allow individuals to focus on diet quality independently of weight loss to mitigate the adverse sequelae of obesity.

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Section: Effects Of Dietary Fat Type On the Gut Microbiotamentioning

confidence: 93%

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Djurić¹

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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“…This omega-3 polyunsaturated fatty acid has been proven to be associated with antiinflammatory [65] and lipid metabolism disorders [66]. The intake of such dietary fatty acids can improve the intestinal flora [67] as well as intestinal inflammation and metabolic disorders in diabetic patients [68]. Tocopherols and phytosterols are rich sources of healthpromoting compounds in Perilla frutescens [69,70].…”

Section: Fatty Acids Tocopherols and Phytosterolsmentioning

confidence: 99%

The Role and Mechanism of Perilla frutescens in Cancer Treatment

Huang

Nan

et al. 2023

Molecules

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Perilla frutescens is an annual herb of the Labiatae family and is widely grown in several countries in Asia. Perilla frutescens is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that Perilla frutescens has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of Perilla frutescens for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of Perilla frutescens for cancer treatment. It was found that the main active components of Perilla frutescens producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of Perilla frutescens are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to Perilla frutescens.

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“…The sections were incubated in periodic acid (Leagene) and Schiff reagent (Leagene) for staining and then counterstained with haematoxylin (Solarbio) as described previously. 61 The staining results were observed under a microscope (Olympus). Five random fields of view were selected for observation.…”

Section: Pas Stainingmentioning

confidence: 99%

Aucubin alleviates methotrexate‐induced enteritis in rats by inducing autophagy

Yang

Lang

Zhao

et al. 2023

Clin Exp Pharma Physio

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One of the toxic side effects of methotrexate (MTX) is enteritis. Aucubin, an iridoid glycoside derived from traditional medicinal herbs, has been proven to have anti‐inflammation, anti‐apoptosis and anti‐oxidation properties. This work explored the effect and mechanism of aucubin in treating MTX‐induced enteritis in a rat model. Two doses of aucubin (5 and 10 mg/kg) were adopted for the assessment of its pharmacological activity. We observed that in rats with MTX‐induced enteritis, the body weight and small intestinal weight decreased. The intestine barrier was injured, as reflected by pathological examinations and an increase in D‐lactate and diamine oxidase concentration in serum. Intestinal inflammation was shown by the observation of macrophages in the intestine and the concentrations of inflammatory cytokines tumour necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) in serum. The NLR family pyrin domain containing 3 (NLRP3) inflammasome was shown to be activated by the enhancement of NLRP3, cleaved‐caspase 1, IL‐18 and IL‐1β. Moreover, autophagy was reflected by transmission electron microscopy as slightly induced, along with changes in autophagy‐related markers microtubule‐associated protein 1 light chain 3 (LC3) and Beclin1. Remarkably, aucubin treatment attenuated the MTX‐induced disease activity index increase, intestinal damage, inflammatory response and NLRP3 inflammasome activation, but provoked autophagy. Rapamycin, an autophagy activator, showed similar therapeutic effects to aucubin on MTX‐induced enteritis. However, 3‐methyladenine, an autophagy inhibitor, reversed the protective effects of aucubin. These findings prompted the hypothesis that aucubin alleviates MTX‐induced enteritis by aggravating autophagy. This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX‐resulted enteritis.

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Perilla Seed Oil Alleviates Gut Dysbiosis, Intestinal Inflammation and Metabolic Disturbance in Obese-Insulin-Resistant Rats

Cited by 19 publications

References 54 publications

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

The Role and Mechanism of Perilla frutescens in Cancer Treatment

Aucubin alleviates methotrexate‐induced enteritis in rats by inducing autophagy

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