Periodontal disease, dental implants, extractions and medications related to osteonecrosis of the jaws

Shah, Neha; Katsarelis, Helen; Pazianas, Michael; Dhariwal, Daljit

doi:10.12968/denu.2015.42.9.878

Cited by 6 publications

(5 citation statements)

References 64 publications

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“…On the other hand, in the oncologic population the incidence seemed to be related to many factors, including the time and type of therapy adopted [ 4 ]. In the last years, many dental conditions and procedures were advocated as triggers of this complication, most of them related to tooth extraction and oral surgery procedures, endodontic treatment, and periodontal therapies [ 6 , 7 , 8 , 9 , 10 , 11 ]. A paper by Ruggiero et al noted that the majority of ONJ cases in oncologic patients treated with BP had previous dental procedures, although the mechanisms of this association were unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Some authors recently concluded that periodontal disease seems to be advocated as a low-grade inflammatory local disease, representing a possible trigger for MRONJ; however, further studies should be performed to clearly state this hypothesis [ 8 , 12 ]. Dental extraction and other surgical procedures have been related to the development of such an invalidating condition [ 9 , 10 ]. Although there are many reports about the onset of this pathology, oral hygiene status is mainly linked as a consequence of MRONJ; not so much is known on the oral hygiene situation as a concurrent factor in the pathogenesis of severe stages and on non-surgical periodontal therapy in patients affected by MRONJ.…”

Section: Introductionmentioning

confidence: 99%

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Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study

D’Agostino

Valentini

Dolci

et al. 2023

IJERPH

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Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related side effect linked but not limited to antiresorptive and antiangiogenic molecules. It recognizes several triggers in dental procedures, such as surgery, endodontic treatments, and root planing, but also prosthesis decubitus or with a spontaneous onset. Although there are many reports about the onset of this pathology, oral hygiene status is mainly described as a consequence of MRONJ. Not so much is known about the oral hygiene situation as a concurrent factor in the pathogenesis of severe stages and about non-surgical periodontal therapy in patients affected by MRONJ. Actually, clear instructions for non-surgical periodontal therapy are poor in the literature. The primary outcome of the present study is to evaluate the oral hygiene status in MRONJ patients. In addition, a secondary outcome is to review the factor of poor oral hygiene as a cause or worsening aspect for MRONJ. A total of 45 subjects (19 males and 26 females) with a mean age of 59 ± 12 were enrolled. The Pearson correlation coefficient showed no significant results for the variable of the Simplified Oral Hygiene Index (OHI-S) and the American Association of Oral and Maxillofacial Surgeons (AAOMS) stage, although the majority of patients showed poor oral hygiene with an OHI-S average of 3.39 ± 1.83. As stated by the last AAOMS position paper, poor plaque control is related to a worsened MRONJ stage. The relation between the lack of oral hygiene and MRONJ onset is still unclear.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study

D’Agostino

Valentini

Dolci

et al. 2023

IJERPH

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“…Pacientes que passaram por tratamento de radioterapia para tumores do complexo buco-maxilo-facial podem apresentar restrições ao emprego de implantes na área irradiada. Diversas alterações pode ocorrer na cavidade bucal, como a diminuição do aporte sangüíneo e danos da radiação à células mesenquimais não-diferenciadas presentes na medula óssea foram apontados como causas do insucesso de implantes nessas regiões, bem como potencializadores do risco de osteorradionecrose associada ao procedimento cirúrgico na região 49 .…”

Section: Sistema Imunológicounclassified

Cuidados pré-operatórios em implantodontia: revisão analítica da literatura pautadas no paciente

Campos¹,

Ferreira

Manfredi

et al. 2020

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A utilização de implantes dentários tem sido cada vez mais uma escolha por parte dos pacientes. Na busca pela reabilitação unitária ou de todos os elementos dentários, os implantes osseointegrados possuem inúmeros benefícios para o restabelecimento da função, estética, fonética e conforto ao paciente. O objetivo dessa revisão de literatura é abordar a importância dos cuidados pré-operatórios que o Implantodontista deve realizar previamente a instalação dos implantes. Para isso, foi realizada uma busca de estudos nas bases de dados Scielo, Lilacs, PubMed e Science Direct. com os descritores “dental implants and installation”, “dental implants and complementary exams” com “and” e “or” como ferramentas integrativas de busca. Observa-se diversos estudos abordandos o comprometimento da taxa de sobrevivência e de sucesso de implantes dentários em pacientes com alguma alteração sistêmica. Quando presente essas alterações, o risco de falhas e complicações são maiores, porém a partir de um adequado exame físico e auxiliados por exames complemetares, é possível mimetizar riscos ao paciente e promover mais sobrevida ao implante. Deve se ressaltar que o tratamento com implantes dentais é um procedimento controlado, seguro e confiável, inclusive na reabilitação dos pacientes idosos. Portanto, cabe ao Implantodontodontista possuir conhecimento para saber avaliar integralmente adequadamente o paciente que será submetido a cirurgia de instalação de implantes.

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“…Tooth extraction due to caries, trauma, or advanced periodontal disease results in a reduction in alveolar ridge volume, both in height and width, leading to morphological changes (1) . After tooth extraction, the width of the alveolar ridge was to be reduced by 50 % during the first 12 months (about 5 to 7 mm), two thirds of this bone loss found to be in the first three months after tooth extraction, indicating that most of the dimensional changes of the alveolar ridge occurs within the first 3 months of healing with a corresponding vertical bone loss of 0.9 to 3.25 mm (2,3) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Milled Tooth Powder versus β-tricalcium phosphate as Bone Grafts on Healing of Tooth Extraction Sockets of Rabbits: An Experimental Study

Youssef

Bayoumi²,

Hassan³

et al. 2022

Egyptian Dental Journal

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Aim: To compare the effects of milled tooth (MT) powder and β-tricalcium phosphate (β-TCP) on healing of extraction sockets in rabbits.Methods: Sixty healthy adult male rabbits were divided into four groups (n=15). After anesthesia the right mandibular first molars were extracted and the treated materials (β-TCP or MT) were gently applied to the extraction sockets forming two groups. In the positive (+ve) control group, sockets healed spontaneously. In the negative (-ve) control group, jaws were left without any interference. Five rabbits from each group were euthanized 10, 20, and 30 days after surgery. Specimens were prepared for light microscopic examination using hematoxylin and eosin, Masson's trichrome staining, and osteopontin. ANOVA was used to assess the statistical significance of the difference between more than two group means. Tukey's multiple comparisons and post-hoc tests were used to explore differences between the means of multiple groups.Results: Regarding osteoid tissue formation by Masson's trichrome staining, a highly significant difference recorded between -ve control, +ve control/10 d, β-TCP/20 d, MT/10 d, and MT/30 d groups. However, no significant differences were detected between the -ve control and +ve control, β-TCP/ 20 d, β-TCP/30 d, and MT/30 d groups. Higher expression of osteopontin were detected in the β-TCP/20 d and MT/30 d groups, and a highly significant difference was observed compared to the +ve control group.Conclusions: MT powder is a biocompatible osteoconductive graft material that can be used as bone graft material in tooth extraction socket healing.

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Periodontal disease, dental implants, extractions and medications related to osteonecrosis of the jaws

Cited by 6 publications

References 64 publications

Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study

Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study

Cuidados pré-operatórios em implantodontia: revisão analítica da literatura pautadas no paciente

Effect of Milled Tooth Powder versus β-tricalcium phosphate as Bone Grafts on Healing of Tooth Extraction Sockets of Rabbits: An Experimental Study

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