Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways

Ni, Lian-Li; Lu, Qian; Tang, Miao; Lu, Tao; Zhao, Hairong; Zhang, Chenggui; Yu, Yun; Wu, Xiumei; Liu, Heng; Cui, Ri

doi:10.1007/s10787-022-00955-7

Cited by 22 publications

(14 citation statements)

References 46 publications

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“…The role of PI3K-AKT in IBD is multiplex. They can regulate epithelium inflammation, epithelium apoptosis, cell proliferation and dendritic cells maturation by regulating different downstream targeted genes [ 42 ], such as NF-κB [ 43 , 44 ], mTOR [ 45 , 46 ], FOXO1, BAD and caspase. Early studies revealed that PI3K-AKT phosphorylation is a key event in the progression of colitis via the activation of inflammatory signaling by regulating NF-κB or mTOR.…”

Section: Discussionmentioning

confidence: 99%

MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

Zhang

Zhang²,

Tang³

et al. 2022

Redox Biology

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Section: Discussionmentioning

confidence: 99%

MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

Zhang

Zhang²,

Tang³

et al. 2022

Redox Biology

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“…In our study, PAE was shown to attenuate a decrease in the expression of TJ proteins (ZO-1 and occludin) in the small intestine of mice tissue and to maintain the intestinal permeability by reducing the extravasation of DAO and D-Lac from the gut into the blood. Other studies have also demonstrated the repairability of PAE on ulcerative colitis (UC) mice by improving the TJs and upregulating their associated proteins in the inflamed colon tissues [ 31 , 32 , 33 ]. A few of the enzymes contained in hepatocytes can be measured in the serum and used to assess liver function, which can be divided into two categories: enzymes that mainly reflect cholestasis, such as the alkaline phosphatase (AKP), and those that primarily reflect hepatocellular necrosis, such as the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice

Chen

et al. 2022

Antioxidants

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Studies have shown that Periplaneta americana extract (PAE) has good therapeutic effects in inflammatory disorders such as ulcerative colitis, alcoholic hepatitis, and gastric ulcers. However, whether or not PAE has good pre-protective effects has not been widely and deeply studied. In this study, we investigated the effects of PAE pretreatment for 7 days on oxidative stress and inflammation triggered by oxidative stress by using diquat-induced C57BL/6 mice as an oxidative stress model. The results showed that PAE pretreatment could significantly reduce oxidative stress in the intestine and liver by reducing the production of MDA, and improved antioxidant systems (SOD, CAT, GSH, and T-AOC). By primarily activating the anti-inflammatory cytokine (IL-10) mediated JAK1/STAT3 signaling pathway, PAE also effectively reduced oxidative stress-induced liver inflammation while also reducing liver damage, as evidenced by the reductions in serum AST and ALT. PAE pretreatment also had a significant effect on maintaining the intestinal barrier function, which was manifested by inhibiting a decrease in the expression of tight junction proteins (ZO-1 and occludin), and reducing the increased intestinal permeability (serum DAO and D-Lac) caused by diquat. The 16S rRNA sequencing analysis revealed that diquat decreased the gut microbiota diversity index and increased the abundance of pathogenic bacteria (e.g. Allobaculum, Providenci,a and Escherichia-Shigella), while PAE pretreatment responded to diquat-induced damage by greatly increasing the abundance of Akkermansia muciniphila. These findings elucidate potential pre-protective mechanisms of PAE in alleviating oxidative stress and inflammation, while providing a direction for the treatment of metabolic diseases by utilizing PAE to enhance the abundance of gut A. muciniphila.

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“…The PAE could inhibit TGF-β1, NF-κB,α-SM, and TIMP-1, thereby blocking relevant signaling pathways and preventing inflammatory responses to attenuate (Dingchun et al, 2018 ). PAE could also decrease the expression of IL-1β, IL-6, IFN-γ, and TNF-α which inhibited the PI3K/AKT/NF-κB signaling pathway, decreasing the expression of inflammatory cytokines (Ni et al, 2022 ). However, it is hard to determine which active component in PAE play a dominant role in curing UC due to abundant compositions in the PAE.…”

Section: Discussionmentioning

confidence: 99%

Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis

Wang

et al. 2022

Drug Delivery

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Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana , which is one of the most common insects in the nature, can be extracted to treat UC. However, the active components in Periplaneta americana extract (PAE) can be degraded in the stomach due to its extreme acidic environment and enzyme. In this study, we developed a pH-dependent drug delivery method using polymer cellulose acetate (Eudragit S100) as a carrier to deliver high concentration PAE to inflamed colon. Both in vitro and in vivo results showed the PAE-Eudragit-S100 could treat UC through delivering active drug components to colon without degradation.

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Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways

Cited by 22 publications

References 46 publications

MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT

Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice

Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis

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