Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure

Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer

“…21 The diagnostic value of serum Prx-1 levels has been shown in patients with lung cancer. 22 Moreover, serum Prx-1 levels also showed diagnostic significance for hepatocellular carcinoma, and which combined with serum a-Fetoprotein (AFP) can increase the ability of diagnosis for hepatocellular carcinoma. 14 Therefore, we developed the potential of Prx-1 for diagnosis of pancreatic cancer.…”

Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation

“…Differentially expressed protein spots were in-gel digested as previously described [14]. In brief, the protein spots were excised from the gels, reduced with DTT, and alkylated with iodoacetamide before in-gel digestion with trypsin (modified sequencing grade porcine trypsin, 0.04 μg/μl, Promega, Madison, WI, USA) for 16 h at +37°C.…”

Antioxidant Defenses in the Lung

“…Most Prx enzymes, especially Prx I, V, and VI, are inducible by oxidative stress or during inflammation, largely mediated by the redoxsensitive transcription factor Nrf2 (see below), and Prx I and VI also show developmental induction of transcription at birth. Expression of Prxs is also elevated in several lung diseases including lung cancer, mesothelioma, and sarcoidosis (Aracena-Parks et al, 2006;Kinnula et al, 2002;Rostila et al, 2012), most likely related to increased constitutive activation of Nrf2 in many cancers with poor prognosis.…”