Pertambahan Berat Badan Mencit (Mus musculus L.) Setelah Perlakuan Ekstrak Air Biji Pepaya (Carica papaya Linn.) Secara Oral Selama 21 Hari

Mardiati, Siti Muflichatun; Sitasiwi, Agung Janika

doi:10.14710/baf.1.1.2016.75-80

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…It was stated that phytochemical compounds can produce side effects such as loss of weight and appetite in experimental animals. Mardiati and Sitasiwi (2016) stated that an increase in body weight is influenced by feed content. Variations in feed content and active ingredients at certain doses can affect animal growth and behavior.…”

Section: Body Weightmentioning

confidence: 99%

Antispermatogenic Activity of Ethanolic Extract of Calina Papaya Leaves on Seminiferous Tubules Wistar Rats

Setiawan

Wulandari²,

Agustina³

2021

J Kedokt Hewan

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Indonesia is a country with high birth rate and the rate continues to increase each year. Methods to reduce high birth rate are needed, especially herbal based contraceptives. This research aims to study the possibility of Calina papaya leaf ethanolic extract as an antispermatogenic agent which hopefully could be expanded into natural antifertiliy drug candidate. Research was done using 24 white male Wistar rats divided into four groups. Dosages were given as follows: 0 mg/Kg W (control group), 100 mg/Kg W (P1), 200 mg/Kg W (P2) and 300 mg/Kg W (P3). Treatment was given in 30 days period. Rats were sacrificed on Day 31 and the testes were taken. Testes were then made into histological specimen using paraffin block and stained using Haematoxylin-Eosin. The diameter and surface area of seminiferous tubules, lumen surface area, and spermatogenesis index were then observed. Results showed that there is a significant difference (p0.05) on lumen surface area and spermatogenesis index between control and treatment groups. It is also found that the optimum dosage given to attain the desirable effect is 300 mg/Kg W. There is no significant difference found on surface area and diameter of tubulus seminiferous between control and treatment group (p0.05). Based on the results, papaya leaf (Calina variety) ethanolic extract has the potential a natural antispermatogenic with the optimum dose of 300 mg/Kg W.

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Section: Body Weightmentioning

confidence: 99%

Antispermatogenic Activity of Ethanolic Extract of Calina Papaya Leaves on Seminiferous Tubules Wistar Rats

Setiawan

Wulandari²,

Agustina³

2021

J Kedokt Hewan

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“…Afolabi et al (2011) menyatakan bahwa biji papaya berpotensi sebagai obat tradisional karena memiliki senyawa yang berperan sebagai antioksidan. Beberapa penelitian menunjukkan bahwa ekstrak biji pepaya dapat digunakan sebagai antidiabetes (Venkasteshwarlu et al, 2013), antifertilitas (Uche-Nacwi et al, 2011;Ekhator and Shelu, 2015), mempengaruhi siklus estrus (Sitasiwi dan Mardiati, 2016). Ikperne et al (2011) menyatakan Carica papaya mengandung beberapa senyawa yang memiliki potensi farmasetika yang dapat mempengaruhi struktur dan fungsi organ dalam tubuh.…”

Section: Pendahuluanunclassified

“…Larutan stok yang telah dibuat, disimpan dalam lemari pendingin pada temperatur 4 o C sampai waktu paparan bahan uji. Pemberian bahan uji dilakukan setelah larutan stok dikeluarkan dari lemari pendingin dan dibiarkan dalam ruangan sampai mencapai suhu kamar (sesuai metode Sitasiwi dan Mardiati, 2016).…”

Section: Menentukan Konsentrasi Bahan Ujiunclassified

Pengaruh Pemberian Ekstrak Air Biji Pepaya (Carica papaya L.) terhadap Stuktur Mikroanatomi Intestinum Tenue Mencit (Mus musculus L.) Betina

Hidayat

Sitasiwi

Mardiati

2021

BAF

Self Cite

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Ekstrak biji Pepaya (Carica papaya L.) mengandung saponin, alkaloid, flavonoid, dan tannin biasa digunakan sebagai bahan obat tradisional. Ekstrak ethanol biji papaya menunjukkan reaksi penghambatan pada kontraksi jejunum dan secara signifikan bersifat irreversible. Penelitian ini bertujuan untuk menguji pengaruh pemberian ekstrak air biji pepaya terhadap struktur mikroanatomi intestinum mencit (Mus musculus L.). Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan yaitu P0 (akuades), P1 (1,4 mg/0,5 ml), P2 (3,5 mg/0,5 ml) dan P3 (7 mg/0,5 ml). Perlakuan dilakukan secara oral selama 21 hari. Pemberian pakan secara ad libitum. Intestinum tenue diisolasi sepanjang 2 cm dari lambung sepanjang 1 cm kemudian di buat sediaan histologis dengan metode parafin dengan tebal sayatan 5 µm dan pewarnaan Hemaktosilin dan Eosin (H&E). Pengukuran panjang vili dan diameter intestinum tenue dilakukan pada 3 sayatan di setiap 3 sediaan histologis intestinum tenue. Data dianalisis dengan uji Anova, dilanjutkan dengan uji Duncan dengan taraf signifikansi 5%. Hasil analisis menunjukan paparan bahan uji tidak berpengaruh signifikan (p>0,05) terhadap panjang vili, dan bobot badan, tetapi menunjukan perbedaan yang signifikan (p,0.05) pada diameter intestinum. Penelitian ini dapat disimpulkan bahwa pemberian ekstrak air biji pepaya selama 21 hari tidak mempengaruhi struktur intestinum tenue mencit sehingga aman digunakan sebagai bahan obat.

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“…Nutritional factors affect individual body weight gain. Nutrients are nutrients also called nutrients contained in feed and then enter the body as feed consumption (Mardiati and Sitasiwi, 2016).…”

Section: Adult Weightmentioning

confidence: 99%

Selection of Weaning and Adult Weight to Increase Growth of Deutch Democratic Yokohama (DDY) Mice

Cahyowati

Baliarti²,

Sumadi³

2021

BuletinPeternak

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This study aims to determine the increase of the growth of Deutch Democratic Yokohama (DDY) strain mice through a selection program from generation 0 (G0, n = 323 ), generation 1 (G1, n = 367) to generation 2 (G2, n = 386). The variables used for the selected program were weaning weight (WW) and adult weight (AW). For WW, the selection was made on the best 50% WW, and for the AW, the selection was carried out by choosing the best eight males and the best 32 females, using the value of genetic parameters and breeding values. Based on the study, WW increased from G0 to G1 and G1 to G2 of 12,63% and 12,05%, respectively. The increase in AW from G0 to G1 and G1 to G2 was 7,85 % and 17,78%, respectively. The conclusion was that it was possible to increase weaning weight and adult weight by selecting the program.

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Pertambahan Berat Badan Mencit (Mus musculus L.) Setelah Perlakuan Ekstrak Air Biji Pepaya (Carica papaya Linn.) Secara Oral Selama 21 Hari

Cited by 5 publications

References 2 publications

Antispermatogenic Activity of Ethanolic Extract of Calina Papaya Leaves on Seminiferous Tubules Wistar Rats

Antispermatogenic Activity of Ethanolic Extract of Calina Papaya Leaves on Seminiferous Tubules Wistar Rats

Pengaruh Pemberian Ekstrak Air Biji Pepaya (Carica papaya L.) terhadap Stuktur Mikroanatomi Intestinum Tenue Mencit (Mus musculus L.) Betina

Selection of Weaning and Adult Weight to Increase Growth of Deutch Democratic Yokohama (DDY) Mice

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