Pharmacological studies of Cordia salicifolia Cham in normal and diabetic rats

Siqueira, Vera Lúcia Dias; Cortez, Diógenes Aparı́cio Garcia; Oliveira, Carlos Eduardo de; Nakamura, Celso Vataru; Bazotte, Roberto Barbosa

doi:10.1590/s1516-89132006000300005

Cited by 11 publications

(15 citation statements)

References 5 publications

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“…Previous studies revealed that C. ecalyculata extract shows inhibitory effects against herpes simplex virus type I (Hayashi et al, 1990), and has cardiotonic properties (Matsunaga et al, 1997), hypolipidemic effects (Siqueira et al, 2006), and cytotoxicity against certain types of tumor cells (Arisawa, 1994). The plant is characterized by high concentrations of caffeine, potassium, allantoic acid, and allantoin (Menghini et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Araldi¹,

Rechiutti²,

Mendes³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Obesity is one of the most important nutritional disorders, and can be currently considered as an epidemic. Although there are few weight reduction drugs available on the market, some new drug candidates have been proposed, including Cordia ecalyculata, a Brazilian plant with anorectic properties, and Spirulina maxima, a cyanobacterium with antioxidant and anti-genotoxic activity. In this study, we evaluated the mutagenic potential of C. ecalyculata at doses of 150, 300, and 500 mg/kg alone and in association with S. maxima at doses of 75, 150, and 250 mg/kg, respectively, through an in vivo micronucleus test, using mice of both sexes, and an in vitro micronucleus test and comet assay, using human peripheral blood. For all tests, cyclophosphamide was used as a positive control. The results showed that treatment of 300 mg/kg C. ecalyculata and the combination treatment of 500 mg/kg C. ecalyculata with 250 mg/kg S. maxima resulted in anorectic effects. The mutagenic tests did not reveal any clastogenic or genotoxic activity for any treatment, indicating that these candidates could be marketed as weight-reduction drugs. Moreover, the drugs contain chemo-preventive substances that can protect against tumorigenesis, which has been associated with obesity.

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Section: Introductionmentioning

confidence: 99%

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Araldi¹,

Rechiutti²,

Mendes³

et al. 2014

Genet. Mol. Res.

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“…Since our fi rst study demonstrating antidiabetic properties of Stevia rebaudiana leaves (Curi et al, 1986), we have been investigating the hypotensive , antiobesity (Siqueira et al, 2006), hypolipidemic (Silva et al, 2004) and antidiabetic (Galletto et al, 2004) properties of the Brazilian plants.…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic effect of the hydroalcoholic extract of leaves of Averrhoa carambola L. (Oxalidaceae)

Ferreira¹,

Fernandes²,

Galende³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Efeito hipoglicemiante do extrato hidroalcoólico de folhas de Averrhoa carambola L. (Oxalidaceae)". O efeito do tratamento via oral (20 mg/kg x day) com extrato hidroalcoólico de folhas de Averrhoa carambola L. (EHFC) sobre a glicemia de jejum (15 h) foi examinada ao compararmos ratos que receberam veículo (Grupo controle) ou EHFC (Grupo EHFC) durante 15 dias. O grupo EHFC apresentou menor glicemia de jejum (p 0,05). Em contraste, o grupo EHFC apresentou maior (p 0,05) produção hepática glicose a partir de L-alanina (5 mM). Este efeito foi mediado, pelo menos parcialmente, pela ativação do catabolismo da L-alanina, inferido pela maior produção hepática de uréia (p 0,05) e L-lactato (p 0,05). Diferente da L-alanina, a produção hepática de glicose a partir de L-glutamina (5 mM), L-lactato (2 mM) e glicerol (2 mM) no grupo EHFC foi similar ao grupo controle. Adicionalmente, o efeito do tratamento com EHFC sobre a captação de glicose no músculo soleus, inferida pela incorporação de [14 C]-glicose em glicogênio (síntese de glicogênio) e produção de [14 C]-lactato foi investigada, verifi cando-se resultados semelhantes nos dois grupos. Assim, concluiu-se que a redução da glicemia de jejum promovida pelo tratamento com EHFC não foi mediada por inibição da gliconeogenese hepática e/ou aumento da captação muscular de glicose.Unitermos: Averrhoa carambola, Oxalidaceae, carambola, gliconeogenese, plantas antidiabeticas, efeito hipoglicemiante. ABSTRACT:The effect of the oral treatment (20 mg/kg x day) with the hydroalcoholic extract of leaves of Averrhoa carambola L. (HELAC) on fasting glycemia (15 h) was examined. For this purpose, rats that received vehicle (Control group) or HELAC (HELAC group) during 15 days were compared. HELAC group showed lower fasting glycemia (p 0.05). In contrast, livers from HELAC group showed higher (p 0.05) glucose production from L-alanine (5 mM). This effect was mediated, at least part of it, by an activation of the catabolism of L-alanine inferred by the increased hepatic urea (p 0.05) and L-lactate (p 0.05) production. Differently of L-alanine, the glucose production from L-glutamine (5 mM), L-lactate (2 mM) and glycerol (2 mM) was similar (Control group vs. HELAC group). In addition, the HELAC treatment did not change the glucose uptake in soleus muscles, inferred by the incorporation of [ 14 C]-glucose to glycogen (glycogen synthesis) and [14 C]-lactate production. Thus, we can conclude that the reduction of fasting glycemia promoted by the treatment with HELAC was not mediated by an inhibition of hepatic gluconeogenesis and/or an increased glucose uptake by muscles.

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“…Carnitine deficiency was obtained by the induction of diabetes. For this purpose, the rats received an intravenous injection (caudal vein) of alloxan (40 mg.kg -1 ) as previously described (Siqueira et al 2006). The control rats received an intravenous injection (caudal vein) of saline.…”

Section: Animalsmentioning

confidence: 99%

“…Therefore, a relevant aspect of the LC supplementation is a lipid-lowering effect observed in the experimental animals (Brady et al 1986;Bell et al 1987;Maccari et al 1987;Feng et al 2001;Hong et al 2002;Rajasekar and Anuradha 2007) and human (Bellinghieri et al 2003;Llias et al 2004;Guarnieri et al 2007;Cha 2008;Bernard et al 2008). On the other hand, diabetes promotes carnitine deficiency (Mamoulakis et al 2004) and increased blood triacylglycerol (Siqueira et al 2006). However, studies investigating the effect of carnitine supplementation on the blood levels of triacylglycerol in type 1 diabetes are absent, not only in the human but also in the experimental animals.…”

Section: Introductionmentioning

confidence: 99%

“…However, studies investigating the effect of carnitine supplementation on the blood levels of triacylglycerol in type 1 diabetes are absent, not only in the human but also in the experimental animals. Thus, considering that alloxan-diabetic rats is a suitable experimental animal model of type 1 diabetes and the fact that these rats show hypertriacylglycerolemia (Siqueira et al 2006), this work investigated the effect of LC and DLcarnitine (DLC) supplementation on the blood levels of triacylglycerol in alloxan-diabetic rats. In addition, the free carnitine (FC) and total carnitine (TC) concentrations in the serum, liver, diaphragm and heart were evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats

Bazotte

Lopes-Bertolini

2012

Braz. arch. biol. technol.

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Pharmacological studies of Cordia salicifolia Cham in normal and diabetic rats

Abstract: ABSTRACT

Cited by 11 publications

References 5 publications

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

Hypoglycemic effect of the hydroalcoholic extract of leaves of Averrhoa carambola L. (Oxalidaceae)

Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats

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