Pharmacological Studies of Perillae Herba. I. Neuropharmacological Action of Water Extract and Perillaldehyde

Sugaya, Akira; Tsuda, Tadashi; Obuchi, Tadashi

doi:10.1248/yakushi1947.101.7_642

Cited by 14 publications

(8 citation statements)

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“…reported that magnorol and honokiol from the ether extract of Magnoliae Cortex show an inhibitory action on the central nervous system [5]. Perillae Herba water extract and its main components of essential oil, perillaldehyde, also has inhibitory action on the central nervous system as described in our previous report [6]. These results are consistent with our observations of the ilK effect.…”

Section: Discussionsupporting

confidence: 93%

Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

et al. 1983

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The actions of the Chinese medicine "Hange-Koboku-To" (HK) and its component crude drugs on the laryngeal reflex, spontaneous locomotor activity and other neuropharmacological actions were studied. The extracts of HK, the barks of Magnolia obovata and aerial parts of Perillafrutescens var. acuta clearly inhibited the laryngeal reflex in cats. The ilK extract also inhibited the locomotor activity in rats, and prolonged the sleeping time induced by hexobarbital sodium in mice. These findings suggest that HK action of removing the foreign body sensation in the throat is mainly due to inhibition of the laryngeal reflex.

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Section: Discussionsupporting

confidence: 93%

Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

et al. 1983

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“…In our study, PAH was inhaled at a dose which was approximately 1.3–130 times lower than the concentration of PAH containing in the water-extract of Perillae Herba (2 g) in kososan, which is used clinically as a one day dosage [12], because rodents have more sensitive olfaction than humans. The inhalation of PAH reduced the immobility in a dose-dependent manner (Figure 2(a)), and did not affect spontaneous locomotor activity (data not shown), indicating that the inhalation of PAH shows an antidepressant-like property.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant‐like Effect of l‐perillaldehyde in Stress‐induced Depression‐like Model Mice through Regulation of the Olfactory Nervous System

Ito

Nagai

Oikawa

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Perillae Herba (a leaf of Perilla frutescens) has been prescribed as one of the component herbs in certain Kampo (Japanese herbal) medicines that are used clinically for the improvement of depressive mood. l-Perillaldehyde (PAH) is a major component in the essential oil containing in Perillae Herba, but its antidepressant-like effect has not been reported. To clarify the antidepressant-like effect of PAH, the inhaled effect of PAH on stress-induced depression-like model mice prepared by subjection to a combination of forced swimming and chronic mild stresses was investigated. The degree of the depression-like state was measured by the animal's duration of immobility using a forced swimming test. Inhalation of PAH (0.0965 and 0.965 mg/mouse/day, 9 days) significantly shortened the duration of immobility of the depression-like model mice and did not affect locomotor activity. However, another odor substance, cinnamaldehyde containing in Cinnamomi Cortex, exhibited no reduction in the immobility. The reduction in the immobility induced by the inhalation of PAH was prevented on anosmia-induced mice prepared by intranasal irrigation with zinc sulfate. These results suggest that the inhalation of PAH shows antidepressant-like activity through the olfactory nervous function.

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“…It is stipulated by the 17th Japanese Pharmacopoeia The Ministry of Health, Labor and Welfare, Japan, 2016 that PA must constitute more than 0.08 of the dry matter of 'Soyou'. PA is an odorant, and has neuropharmacological effects Sugaya et al, 1981, vasodilative effects Takagi et al, 2005, antidepressant-like effects Ito et al, 2008, and bactericidal action Oda et al, 1982a1982b . ANT is a red pigment, and an antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Effects of nutrient solution temperature on the concentration of major bioactive compounds in red perilla

Ogawa

Hikosaka

Gotō

2018

J. Agric. Meteorol.

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Red perilla Perilla frutescens is used as food, stomachic and antitussive crude drugs, and anti-allergy supplements. The major bioactive compounds of red perilla are perillaldehyde PA , rosmarinic acid RA , luteolin LU , and anthocyanin ANT . In this study, we investigated the effects of 6 days low 10, 12, and 15°C and control 20°C nutrient solution temperature NST treatments on plant growth and major bioactive compound concentrations in red perilla leaves at the node position. No significant difference was detected in the dry weight of leaves of the main shoot, which is the main part harvested, among the treatments. However, leaf water content tended to decrease with a decrease in NST, especially in plants grown at 10°C NST, which exhibited values significantly lower than those of plants grown at 15°C and 20°C NSTs. PA and ANT concentrations in the 3rd to 5th nodes did not differ among treatments. Conversely, RA concentration increased with a decrease in NST, irrespective of the node position. LU concentration at 10°C NST was the highest in all treatments, irrespective of the node position. This suggested that the production of bioactive compounds under the low NSTs differed depending on leaf maturity stage and compound. Additionally, the contents of RA and LU in the whole plant increased because there was no reduction in growth of the harvested part under the low NSTs. Therefore, 6 days exposure to root-zone temperatures at 10°C appears to be an effective method to increase both RA and LU concentrations and their contents in the whole plant of red perilla for its use as a crude drug or medicinal material.

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Pharmacological Studies of Perillae Herba. I. Neuropharmacological Action of Water Extract and Perillaldehyde

Cited by 14 publications

References 0 publications

Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

Effect of Chinese Herbal Medicine „Hange-Koboku-To” on Laryngeal Reflex of Cats and in other Pharmacological Tests

Antidepressant‐like Effect of l‐perillaldehyde in Stress‐induced Depression‐like Model Mice through Regulation of the Olfactory Nervous System

Effects of nutrient solution temperature on the concentration of major bioactive compounds in red perilla

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