Phenethyl Isothiocyanate Inhibits Proliferation and Induces Apoptosis in Pancreatic Cancer Cells<i>In Vitro</i>and in a MIAPaca2 Xenograft Animal Model

Stan, Silvia D.; Singh, Shivendra V.; Whitcomb, David C.; Brand, Randall E.

doi:10.1080/01635581.2013.795979

Cited by 28 publications

(18 citation statements)

References 46 publications

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“…Kallifatidis et al [ 35 ] showed that sulforaphane in combination with TRAIL may be a promising strategy for targeting treatment-resistant pancreatic tumor-initiating cells. Additionally, benzyl isothiocyanate and phenethyl isothiocyanate have also been shown to inhibit proliferation and induce apoptosis in pancreatic cancer cells in vitro and in vivo [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Luo

et al. 2015

World J Surg Onc

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BackgroundPrevious studies regarding the association between cruciferous vegetable intake and pancreatic cancer risk have reported inconsistent results. We conducted a meta-analysis to demonstrate the potential association between them.MethodsA systematic literature search of papers was conducted in March 2014 using PubMed, EMBASE, and Web of Science, and the references of the retrieved articles were screened. The summary odds ratios (ORs) with 95% confidence interval (CI) for the highest versus the lowest intake of cruciferous vegetables were calculated.ResultsFour cohort and five case–control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables (OR 0.78, 95% CI 0.64–0.91). Moderate heterogeneity was detected across studies (P = 0.065). There was no evidence of significant publication bias based on Begg’s funnel plot (P = 0.917) or Egger’s test (P = 0.669).ConclusionsCruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Luo

et al. 2015

World J Surg Onc

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“…The hydrolysis of these glucosinolates by the plant enzyme myrosinase generates biologically active isothiocyanates (ITC) 167 and indoles 168 . Many studies have shown that ITCs exert anti-cancer effects through inhibition of HDAC activity and histone hyperacetylation, as reported for sulforaphane (SFN) 169, 170 , allyl isothiocyanate (allyl-ITC) 95 , benzyl isothiocyanate (BITC) 96 , phenylhexyl isothiocyanate (PHITC) 98 , phenethyl isothiocyanate (PEITC) 102 , and other longer-chain isothiocyanates 171 .…”

Section: 0 Protein Acetylation and Dietary Chemopreventive Agentsmentioning

confidence: 99%

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors

Kim¹,

Bisson²,

Löhr³

et al. 2015

CTMC

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Acetylation is an important, reversible post-translational modification affecting histone and non-histone proteins with critical roles in gene transcription, DNA replication, DNA repair, and cell cycle progression. Key regulatory enzymes include histone deacetylase (HDACs) and histone acetyltransferases (HATs). Overexpressed HDACs have been identified in many human cancers, resulting in repressed chromatin states that interfere with vital tumor suppressor functions. Inhibition of HDAC activity has been pursued as a mechanism for re-activating repressed genes in cancers, with some HDAC inhibitors showing promise in the clinical setting. Dietary compounds and their metabolites also have been shown to modulate HDAC activity or expression. Out of this body of research, attention increasingly has shifted towards non-histone targets of HDACs and HATs, such as transcriptions factors, hormone receptors, DNA repair proteins, and cytoskeletal components. These aspects are covered in present review, along with the possible clinic significance. Where such data are available, examples are cited from the literature of studies with short chain fatty acids, polyphenols, isoflavones, indoles, organosulfur compounds, organoselenium compounds, sesquiterpene lactones, isoflavones, and various miscellaneous agents. By virtue of their effects on both histone and non-histone proteins, dietary chemopreventive agents modulate the cellular acetylome in ways that are only now becoming apparent. A better understanding of the molecular mechanisms will likely enhance the potential to more effectively combat diseases harboring altered epigenetic landscapes and dysregulated protein signaling. Dietary chemopreventive agents modulate the cellular acetylome by affecting both histone and non-histone proteins, which will likely enhance their potential to more effectively combat diseases harboring altered epigenetic landscapes.

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“…In these processes, signalling pathways such as AKT, STAT3, histone deacetylase (HDAC) and NF-κB are involved [75]. Xenotransplanted mice treated with phenethyl isothiocyanate show less tumour volume in comparison to controls [89]. Benzyl isothiocynate entails weight loss, physical inactivity, but no toxicity in a mouse model [42,90].…”

Section: Isothiocyanatesmentioning

confidence: 99%

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

Benzel

Fendrich

2018

Digestion

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Background: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. Summary: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins. This review aims to give an overview on potential risk factors for the development of pancreatic cancer. Furthermore, we try to summarise known chemopreventive agents to support the fight against this lethal disease. Key Messages: On the one hand, there are natural agents that exhibit preventive properties and can lead to the prohibition of pancreatic cancer. On the other hand, there are drugs and agents that are currently used in other contexts and are thus already approved and studied in terms of their mechanisms of effects and the related secondary effects.

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Phenethyl Isothiocyanate Inhibits Proliferation and Induces Apoptosis in Pancreatic Cancer CellsIn Vitroand in a MIAPaca2 Xenograft Animal Model

Cited by 28 publications

References 46 publications

Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors

Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature

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