The elimination capacity of pristine powder activated charcoal PAC and powder activated charcoal modified with potassium permanganate MPAC to remove levocetirizine drug was investigated. The activated charcoal was impregnated with KMnO 4 100 mg/L in order to improve the surface properties. The influence of concentration, time and pH on the adsorption of levocetirizine drug was conducted by means of UV-Vis spectroscopy. The experiments were carried out using two lines. Line 1; adsorption of the drug on pristine PAC and line 2; adsorption on MPAC. By batch experiments, the effect of levocetirizine concentrations of 25, 50, 75, and 100 mg/L, a reaction time of 15, 30, 45 and 60 min, and pH of 2, 4, 7 and 9 were investigated. The results showed that elimination capacity of both PAC and MPAC increased with increasing the drug concentration and time of contact and decreased with decreasing the pH. The elimination efficiency of MPAC found to be greater than that of PAC. INTRODUCTION: Activated charcoal is one of the main effective adsorbents which has a high surface area, large pore volume, tunable pore size, chemical stability and high hydrophobicity 1, 2, 3. It is in the shape of a fine black odorless, tasteless, microcrystalline powder 4. Due to its high adsorptive capacity is used as an adsorbent for a large variety of compounds. It is used for removal of colors from solutions 5, 6. Activated charcoal is used in the adsorption of gases and vapors such as ammonia, carbon tetrachloride, methane, nitrogen dioxide and carbon dioxide 7, 8, 9. A large number of studies concern the adsorption of a verity of organic compounds on activated charcoal have been conducted.