Phenolic composition, antioxidant and acetylcholinesterase inhibitory activities of Sclerocarya birrea and Harpephyllum caffrum (Anacardiaceae) extracts

Moyo, Mack; Ndhlala, A.R.; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.foodchem.2010.03.130

Cited by 125 publications

(78 citation statements)

References 30 publications

(40 reference statements)

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“…High antioxidant capacities are observed in plants with high level of phenolic compounds (Moyo et al, 2010). The redox properties of phenolic compounds, which enable them to act as reducing agents, hydrogen donors and singlet oxygen scavengers account for the antioxidant potential of medicinal plants (Hakkim et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Bauhinia variegata L. bark fractions for in vitro antioxidant potential and protective effect against H2O2-induced oxidative damage to pBR322 DNA

Sharma¹

2011

Afr. J. Pharm. Pharmacol.

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Bauhinia variegata L. (Fabaceae) is widely used inIndian traditional medicine. The present study was undertaken to evaluate the protective effect of different fractions from the crude methanolic extract of B. variegata L. bark against free radicals and H 2 O 2 -induced oxidative damage to pBR322 DNA. 80% methanol extract (MEB) of the bark was fractionated into non-polar fractions, including hexane (HEB), chloroform (CFB) fractions and Polar fractions, including n-butanol (NBB), ethyl acetate (EAB) and remaining extract (REB). The extact/fractions were analysed for total phenolic and flavonoid content and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assays while the genoprotective activity was assessed using DNA nicking assay. The polar fractions, MEB, EAB, NBB and REB showed greater antioxidant activity (EC 50 44.07, 58.09, 69.68 and 51.81 g/ml, respectively) in comparison to non-polar fractions. However, all the fractions effectively protected pBR322 plasmid DNA from the H 2 O 2 induced damage. The phytochemical analysis of the polar fractions revealed them to be rich in the phenolic/flavonoid content and that significant correlation existed between phenolic/flavonoid content and antioxidant activity. Our studies showed that the phytoconstituents of B. variegata harbour the potential to combat various free-radicals and need further investigation.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Bauhinia variegata L. bark fractions for in vitro antioxidant potential and protective effect against H2O2-induced oxidative damage to pBR322 DNA

Sharma¹

2011

Afr. J. Pharm. Pharmacol.

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“…The inhibitory action of Z. album extracts against acetylcholinesterase activity would be related to their content of polyphenols, flavonoids, sterols and alkaloids. Recently, it was reported that these compounds have been shown to possess antiacetylcholinesterase properties (Ji and Zhang, 2008;Farlow, 2009;Sacan and Yanardag, 2010;Zhao et al, 2013;Moyo et al, 2010;Cao et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidant and anti-acetylcholinesterase activities of Zygophyllum album

Kchaou

Salah

Mhiri

et al. 2015

Bangladesh J Pharmacol

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The present study was carried out to explore the anti-acetylcholinesterase activity and anti-oxidant effect as well as content of phenolic compounds of various extracts from Zygophyllum album. It was observed that dichloromethane and ethanol extracts were endowed with a powerful anti-acetylcholinesterase activity with IC50 values of 40 and 58 µg/mL, respectively. These two extracts exhibited the highest DPPH radical scavenging activity (IC50=0.2 mg/mL), the highest total anti-oxidant capacity (185.2 and 222.4 mg vitamin E/mg extract, respectively), the highest reducing power effect, and the highest β-carotene bleaching capacity. The findings showed that the extents of anti-acetylcholinesterase activity of Z. album extracts as well as their anti-oxidant capacity are in accordance with their phenolic contents. Hence, Z. album leaves would be useful against Alzheimer's disease. VIDEO CLIP<a href="https://www.youtube.com/v/M03zi4Mzh6k">Determination of flavonoids content:</a> 2 min 50 sec

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“…To determine the antioxidant activity of the extracts based on their capacity to reduce ferric ion (Fe +3 ) into ferrous ion (Fe +2 ) [20], extracts at concentrations ranging from 800-6.25 µg/ml and ascorbic acid (50-0.39 µg/ml) were dissolved in 50 % aqueous methanol solution and FRAP assays were conducted. In each well of the 96 wells plate, 30 µl of each plant extract concentration or ascorbic acid was added.…”

Section: Frap Assaymentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of Selected Plants Used by Populations From Juruena Valley, Legal Amazon, Brazil

Silva

Arunachalam

Miyajima

et al. 2017

Int J Pharm Pharm Sci

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Objective: The purpose of this study was to evaluate selected Brazilian plants from Juruena valley region of Mato Grosso, for their in vitro antimicrobial and antioxidant activities. Methods:The powder obtained from different parts of the twenty-six (26) plants were macerated in hydroethanolic solution to obtain the extracts. The hydroethanolic extracts were tested for their in vitro antimicrobial activity by determining the MIC using broth microdilution. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, ferric reducing antioxidant power (FRAP) and nitric oxide (NO) methods were used for the determination of antioxidant activities. Correlation between classes of secondary metabolites and antioxidant activity was assessed.Results: Phanera glabra extract (HEPg) showed broad antibacterial spectrum, presenting the best activity against Klebsiella pneumoniae. Hevea microphylla extract (HEHm) presented a narrow spectrum of antibacterial activity with strong effect against Shigella flexneri. The only plant with broad spectrum antifungal activity was Bertholletia excelsa (HEBe), with moderate activity against strains of Aspergillus and Candida. The following extracts were prominent regarding their activities in the DPPH and FRAP assays-HEBe, Cariniana rubra (HECr) and in the FRAP assay alone, Cedrela odorata (HECo) and HEPg. None of the extracts was active in the NO assay. A significant association was observed between DPPH activity and the total phenolic contents. Conclusion:Our results justified the use of some of the investigated plants in the Brazilian ethnomedicine. The antibacterial activities of these plants are bacteriostatic in nature. These findings support that a number of investigated plants could be a valuable source of new antioxidant and antimicrobial compounds that can potentially deliver novel mechanisms of actions. However, further studies are required.

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Phenolic composition, antioxidant and acetylcholinesterase inhibitory activities of Sclerocarya birrea and Harpephyllum caffrum (Anacardiaceae) extracts

Cited by 125 publications

References 30 publications

Evaluation of Bauhinia variegata L. bark fractions for in vitro antioxidant potential and protective effect against H2O2-induced oxidative damage to pBR322 DNA

Evaluation of Bauhinia variegata L. bark fractions for in vitro antioxidant potential and protective effect against H2O2-induced oxidative damage to pBR322 DNA

Anti-oxidant and anti-acetylcholinesterase activities of <i>Zygophyllum album</i>

Antimicrobial and Antioxidant Activities of Selected Plants Used by Populations From Juruena Valley, Legal Amazon, Brazil

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