Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation

Wang, Zhong Q.; Qin, Jianhua; Martin, Julie; Zhang, Xian H.; Sereda, Olga; Anderson, Richard A.; Pinsonat, Patricia; Cefalu, William T.

doi:10.1016/j.metabol.2007.07.007

Cited by 56 publications

(46 citation statements)

References 11 publications

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“…Baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to chromium. 25 In contrast, in this study, the baseline FPG levels in both the chromium and placebo groups were normal (Table 1). Our results are consistent with a meta-analysis finding no association between chromium and glucose or insulin concentrations among nondiabetic subjects.…”

Section: Discussioncontrasting

confidence: 64%

“…24 Some reports suggest that chromium could suppress appetite and stimulate thermogenesis through sensitization of insulin-sensitive glucoreceptors in the brain. 25 Body fat distribution is related to insulin sensitivity; peripheral fat is more insulin sensitive than central fat found in the chest and abdomen. 26 A meta-analysis of 10 double-blind, placebo-controlled trials provides evidence of a relatively small reduction in body weight (1.1-1.2 kg over 10-13 weeks) in overweight and obese individuals receiving chromium picolinate.…”

Section: Introductionmentioning

confidence: 99%

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A Pilot Study of Chromium Picolinate for Weight Loss

Yazaki

Faridi

et al. 2010

The Journal of Alternative and Complementary Medicine

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Background: Chromium is an essential trace element and nutritional supplement that has garnered interest for use as a weight loss aid. Objective: This trial assesses the effects of chromium picolinate supplementation, alone and combined with nutritional education, on weight loss in apparently healthy overweight adults. Design: This was a randomized, double-blind, placebo-controlled trial of 80 otherwise healthy, overweight adults assessed at baseline for central adiposity measured by computerized tomography. Subjects were randomly assigned to daily ingestion of 1000 mg of chromium picolinate or placebo for 24 weeks. All subjects received passive nutritional education at the 12-week point in both the intervention and control groups. Outcomes include weight, height, blood pressure, percent body fat, serum, and urinary biomarkers. Results: At baseline, both the chromium and placebo groups had similar mean body mass index (BMI) (chromium ¼ 36 AE 6.7 kg=m 2 versus placebo ¼ 36.1 AE 7.6 kg=m 2 ; p ¼ 0.98). After 12 weeks, no change was seen in BMI in the intervention as compared to placebo (chromium ¼ 0.3 AE 0.8 kg=m 2 versus placebo ¼ 0.0 AE 0.4 kg=m 2 ; p ¼ 0.07). No change was seen in BMI after 24 weeks in the intervention as compared to placebo (chromium ¼ 0.1 AE 0.2 kg=m 2 versus placebo ¼ 0.0 AE 0.5 kg=m 2 ; p ¼ 0.81). Variation in central adiposity did not affect any outcome measures. Conclusions: Supplementation of 1000 mg of chromium picolinate alone, and in combination with nutritional education, did not affect weight loss in this population of overweight adults. Response to chromium did not vary with central adiposity.

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Section: Discussioncontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Chromium Picolinate for Weight Loss

Yazaki

Faridi

et al. 2010

The Journal of Alternative and Complementary Medicine

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“…In relation to the lack of effect of supplementation, CrPic can play an antioxidant effect when there is an oxidative disruption, because CrPic supplementation could preserve the antioxidant status when there are a depletion of antioxidant enzymes and an increase in oxidative stress [51][52][53]. In the present study, positive action of CrPic was not observed, likely because there was no depletion of antioxidant enzymes or increased oxidative stress in our sample.…”

Section: Discussionmentioning

confidence: 63%

Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate

et al. 2018

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(2018) Aerobic training reduces oxidative stress in skeletal muscle of rats exposed to air pollution and supplemented with chromium picolinate, Redox Report, 23:1, 146-152, DOI: 10.1080/13510002.2018 Objective: The purpose of this study was to investigate the effects of chromium picolinate (CrPic) supplementation associated with aerobic exercise using measures of oxidative stress in rats exposed to air pollution. Methods: Sixty-one male Wistar rats were divided into eight groups: residual oil fly ash (ROFA) exposure and sedentary (ROFA-SED); ROFA exposure, sedentary and supplemented (ROFA-SEDCrPic); ROFA exposure and trained (ROFA-AT); ROFA exposure, supplemented and trained (ROFA-AT-CrPic); sedentary (Sal-SED); sedentary and supplemented (Sal-SED-CrPic); trained (Sal-AT); and supplemented and trained (Sal-AT-CrPic). Rats exposed to ROFA (air pollution) received 50 μg of ROFA daily via intranasal instillation. Supplemented rats received CrPic (1 mg/kg/day) daily by oral gavage. Exercise training was performed on a rat treadmill (5×/week). Oxidative parameters were evaluated at the end of protocols. Results: Trained groups demonstrated lower gain of body mass (P < .001) and increased exercise tolerance (P < .0001). In the gastrocnemius, trained groups demonstrated increased SOD activity (P < .0001) and decrease levels of TBARS (P = .0014), although CAT activity did not differ among groups (P = .4487). Conclusion: Air pollution exposure did not lead to alterations in oxidative markers in lungs and heart, and exercise training was responsible for decreasing oxidative stress of the gastrocnemius.

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“…Chromium is known for its beneficial influence on the glucose level in diabetic patients ( 20 , 21 ). The presumption is that chromium supplementation works whenever its blood level is low ( 21 ). However, chromium levels in diabetic patients are not examined before chromium supplementation.…”

Section: Discussionmentioning

confidence: 99%