Photoacoustic Drug Delivery

Zhang, Yuqi; Yu, Jicheng; Kahkoska, Anna R.; Gu, Zhen

doi:10.3390/s17061400

Cited by 40 publications

(30 citation statements)

References 116 publications

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“…The presence of an empty cavity makes MNCs very attractive as carriers for drug delivery under PA and/or NIR fluorescence guidance, and MNCs have unique potential for multimodal imaging (eg, PA and fluorescence) and multifunctional applications (eg, PA diagnosis, PT therapy, magnetic manipulation and drug delivery). Multimodal nanomaterials play a key role in modern science, primarily owing to their attractive medical applications . A fascinating example of the most recent achievements in this field is the preparation of metal ion/tannic acid assemblies with excellent PT efficiency (η ≈ 40%) in combination with four types of imaging tools, including PT and PA imaging (PAI) and MRI and NIR fluorescence imaging .…”

Section: Discussionmentioning

confidence: 99%

Photoacoustic and fluorescent effects in multilayer plasmon‐dye interfaces

Новоселова

Bratashov

Sarimollaoglu

et al. 2019

Journal of Biophotonics

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Progress in understanding the cell biology and diseases depends on advanced imaging and labeling techniques. Here, we address this demand by exploring novel multilayered nanocomposites (MNCs) with plasmonic nanoparticles and absorbing dyes in thin nonabsorbing shells as supercontrast multimodal photoacoustic (PA) and fluorescent agents in the near-infrared range. The proof of concept was performed with gold nanorods (GNRs) and indocyanine green (ICG) dispersed in a matrix of biodegradable polymers. We demonstrated synergetic PA effects in MNCs with the gold-ICG interface that could not be achieved with ICG and GNRs alone. We also observed ultrasharp PA and emission peaks that could be associated with nonlinear PA and spaser effects, respectively. Low-toxicity multimodal MNCs with unique plasmonic, thermal and acoustic properties have the potential to make a breakthrough in PA flow cytometry and near-infrared spasers in vivo by using the synergetic interaction of plasmonic modes with a nearby absorbing medium. K E Y W O R D S biocompatible polymers, fluorescence, fluorescence quenching, gold nanorods, in vivo flow cytometry, indocyanine green, multilayer composite, photoacoustic effect

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Section: Discussionmentioning

confidence: 99%

Photoacoustic and fluorescent effects in multilayer plasmon‐dye interfaces

Новоселова

Bratashov

Sarimollaoglu

et al. 2019

Journal of Biophotonics

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“…For CVD therapy, local delivery at sites of atherosclerotic lesions includes stent-coating with polymers and hydrogels containing and releasing therapeutic RNAs ( Koenig et al, 2017 ). Also, modern transfection methods could be adaptable to deliver circRNAs during cardiovascular operations, including photo-/optoacoustic approaches, which allow defining target cells and delivering cargo via nanostructures ( Zhang Y. et al, 2017 ).…”

Section: Therapeutic Delivery Of Circrnasmentioning

confidence: 99%

Circular RNAs as Therapeutic Agents and Targets

2018

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It has recently been reported that thousands of covalently linked circular RNAs (circRNAs) are expressed from human genomes. circRNAs emerge during RNA splicing. circRNAs are circularized in a reaction termed “backsplicing,” whereby the spliceosome fuses a splice donor site in a downstream exon to a splice acceptor site in an upstream exon. Although a young field of research, first studies indicate that backsplicing is not an erroneous reaction of the spliceosome. Instead, circRNAs are produced in cells with high cell-type specificity and can exert biologically meaningful and specific functions. These observations and the finding that circRNAs are stable against exonucleolytic decay are raising the question whether circRNAs may be relevant as therapeutic agents and targets. In this review, we start out with a short introduction into classification, biogenesis and general molecular mechanisms of circRNAs. We then describe reports, where manipulating circRNA abundance has been shown to have therapeutic value in animal disease models in vivo, with a focus on cardiovascular disease (CVD). Starting from existing approaches, we outline particular challenges and opportunities for future circRNA-based therapeutic approaches that exploit stability and molecular effector functions of native circRNAs. We end with considerations which designer functions could be engineered into artificial therapeutic circular RNAs.

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“…Furthermore by using exogenous contrasts, molecular PAI enables visualizing specific cellular functions and molecular processes, to further enhance the imaging signal, especially those materials with strong absorption in the near-infrared (NIR) region where optical attenuation is weaker than the visible light region in vivo. In recent years, great efforts have been devoted to enhance the molecular imaging capability of PAI, and considerable progress has been made in optimizing both the PAI systems for better detection sensitivity, and the contrast agents for better contrast enhancement [75][76][77][78]. A limitation of PAI may be that the probe should be in physical contact with the tissue, the measurements cannot be done in a non-contact way.…”

Section: Photoacoustic Imaging Technical Backgroundmentioning

confidence: 99%