Photochemical property of two Ru(II) compounds based on 5-(2-pyrazinyl)tetrazole for cancer phototherapy by changing auxiliary ligand

Yang, Jie; Xu, Yue; Jiang, Min; Zou, Dengfeng; Yang, Gao‐Wen; Shen, Lei; Zou, Jianhua

doi:10.1016/j.jinorgbio.2019.01.015

Cited by 25 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, we have reported a series of tetrazole carboxylate–based complexes as nanoboosters, which can boost O 2 or H 2 O 2 to generate ROS to induce cancer cell apoptosis, exhibiting high toxicity and excellent biocompatibility for photodynamic therapy ( Yang G et al, 2018 ; Zhai et al, 2018 ; Yang et al, 2019 ; Zhu et al, 2019 ; Xu et al, 2020 ; Yang et al, 2020 ). As an extension of our research, the tetrazole carboxylic acid ligand–based H 4 L ( Scheme 1 ) was selected for self-assembly with Gd(III)–Cu(II) ions, and a new heteronuclear complex [Gd 2 Cu(L) 2 (H 2 O) 10 ]·6H 2 O was obtained with good antitumor properties ( Scheme 1 ).…”

Section: Introductionmentioning

confidence: 99%

Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells

et al. 2022

Self Cite

View full text Add to dashboard Cite

Copper (II) containing coordination complexes have attracted much attention for chemodynamic therapy (CDT) against cancer cells. In this study, the bimetallic nanobooster [Gd2Cu(L)2(H2O)10]·6H2O was prepared by a solvothermal method based on tetrazole carboxylic acid ligand H4L [H4L = 3,3-di (1H-tetrazol-5-yl) pentanedioic acid]. It showed considerable cytotoxicity toward three kinds of human cancer cells (HeLa, HepG2, and HT29). The MTT assay showed that the IC50 (half-maximal inhibitory concentration) of the complex NPs on HeLa cells (4.9 μg/ml) is superior to that of HepG2 (11.1 μg/ml) and HT29 (5.5 μg/ml). This result showed that [Gd2Cu(L)2(H2O)10]·6H2O NPs can inhibit cell proliferation in vitro and may be potential candidates for chemodynamic therapy. In addition, the cytotoxicity was also confirmed by the trypan blue staining experiment. The results promise the great potential of Gd(III)–Cu(II) for CDT against cancer cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies involving the combination of the flavonoid quercetin with PDT revealed reduced cell viability of cervical adenocarcinoma and breast carcinoma cells [ 24 , 25 ]. Furthermore, some complexes have been investigated, such as the agent chelators 2,2′-bipyridyl and 1,10-phenanthroline, which were studied in metallic complexes and presented toxicity in cervical adenocarcinoma HeLa cells [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Phototoxic Potential of Different DNA Intercalators for Skin Cancer Therapy: In Vitro Screening

Pivetta

Vieira

Silva

et al. 2023

IJMS

View full text Add to dashboard Cite

Photodynamic therapy is a minimally invasive procedure used in the treatment of several diseases, including some types of cancer. It is based on photosensitizer molecules, which, in the presence of oxygen and light, lead to the formation of reactive oxygen species (ROS) and consequent cell death. The selection of the photosensitizer molecule is important for the therapy efficiency; therefore, many molecules such as dyes, natural products and metallic complexes have been investigated regarding their photosensitizing potential. In this work, the phototoxic potential of the DNA-intercalating molecules—the dyes methylene blue (MB), acridine orange (AO) and gentian violet (GV); the natural products curcumin (CUR), quercetin (QT) and epigallocatechin gallate (EGCG); and the chelating compounds neocuproine (NEO), 1,10-phenanthroline (PHE) and 2,2′-bipyridyl (BIPY)—were analyzed. The cytotoxicity of these chemicals was tested in vitro in non-cancer keratinocytes (HaCaT) and squamous cell carcinoma (MET1) cell lines. A phototoxicity assay and the detection of intracellular ROS were performed in MET1 cells. Results revealed that the IC50 values of the dyes and curcumin in MET1 cells were lower than 30 µM, while the values for the natural products QT and EGCG and the chelating agents BIPY and PHE were higher than 100 µM. The IC50 of MB and AO was greatly affected by irradiation when submitted to 640 nm and 457 nm light sources, respectively. ROS detection was more evident for cells treated with AO at low concentrations. In studies with the melanoma cell line WM983b, cells were more resistant to MB and AO and presented slightly higher IC50 values, in line with the results of the phototoxicity assays. This study reveals that many molecules can act as photosensitizers, but the effect depends on the cell line and the concentration of the chemical. Finally, significant photosensitizing activity of acridine orange at low concentrations and moderate light doses was demonstrated.

show abstract

“…In our previous research, Ru/Ca( ii )/Cu( ii )-tetrazole–carboxylate complexes showed low IC 50 on HeLa cells, indicating that the diversity and versatility of organic ligands can be harnessed to develop coordination complexes with promising anti-cancer activities. 22–28 Since studies on complexes based on tetrazole-carboxylate-based ligands for cancer treatment are far from satisfactory. Zn( ii ) is a trace element essential for the normal function of cells and plays an important role in the development of various cancers.…”

Section: Introductionmentioning

confidence: 99%

Bifunctional tetrazole–carboxylate ligand based Zn(ii) complexes: synthesis and their excellent potential anticancer properties

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Photochemical property of two Ru(II) compounds based on 5-(2-pyrazinyl)tetrazole for cancer phototherapy by changing auxiliary ligand

Cited by 25 publications

References 30 publications

Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells

Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells

Phototoxic Potential of Different DNA Intercalators for Skin Cancer Therapy: In Vitro Screening

Bifunctional tetrazole–carboxylate ligand based Zn(ii) complexes: synthesis and their excellent potential anticancer properties

Contact Info

Product

Resources

About