Physikalisch-chemische Grundlagen der mikrobiziden Wirkung wäßriger PVP-Jod-Lösungen

Horn, D.; Ditter, W.

doi:10.1007/978-3-642-69443-1_2

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…A sufficiently precise evaluation, therefore, can be based on the sole determination of [I 2 ] (e.g. potentiometrically [12] or by dialysis [13] ) and [I -] (iodide electrode) while triiodide is calculated from both.…”

Section: Analytical Consequencesmentioning

confidence: 99%

Iodine and Disinfection: Theoretical Study on Mode of Action, Efficiency, Stability, and Analytical Aspects in the Aqueous System

Gottardi

1999

Arch. Pharm. Pharm. Med. Chem.

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Although they have been in use for nearly 170 years, the mode of action of iodine‐based disinfectants is not yet clearly understood, as is manifested, for example, in diverging judgements about the relevance of the individual iodine species. Although studies based on calculated equilibrium concentrations in pure iodine solutions have already been done, there is a lack of knowledge about iodine solutions in the presence of additional iodide which would be of intrinsic importance for disinfection practice. Therefore, a re‐calculation was undertaken considering variations of this parameter in the pH range 0—14. The presented calculations concern fresh iodine solutions not affected by disproportionation (iodate formation) and provide information about the equilibrium concentrations of the species I‐, I2, I3‐, I5‐, I62, HOI, OI‐, HI2O‐, IO2‐, and H2OI+. Additional iodide and the pH value have a very pronounced influence on the individual equilibrium concentrations (several powers of ten); hence, conditions can be indicated where the number of species of virtual importance is drastically reduced. In the most common case with iodine in the presence of additional iodide at pH < 6, only I‐, I2, and I3‐ play a role. In the absence of additional iodide, at pH 8‐9 and at high dilution (c(I2) < 10‐5M), on the other hand, HOI accounts for over 90% of the oxidation capacity. At high iodide concentration (e.g. Lugol′s solution) the species I5‐ and I62‐ make up 8.2% of the oxidation capacity. The iodine cation H2OI+, frequently quoted as an active agent in disinfection, is without any relevance under the conditions occurring in practice, as are IO‐ and HI2O‐ which become important only at pH > 10. The stability problem (i.e. rate of iodate formation) arising at pH > 6 can be reduced to hypoiodous acid, as manifested in the simple rate law d[IO3‐]/dt = 0.25[HOI]3/[H+] which allows an estimation of stability under weakly alkaline conditions. The results of this study allow us to deduce general qualities of aqueous iodine solutions, such as reactivity, stability, and analytical aspects, and to estimate major disinfection‐orientated properties such as microbicidal activity, irritation, and incorporation effects. Though the calculations consider primarily preparations devoid of polymeric organic compounds capable of complexing iodine species, the results can be largely transferred to iodophoric preparations.

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Section: Analytical Consequencesmentioning

confidence: 99%

Iodine and Disinfection: Theoretical Study on Mode of Action, Efficiency, Stability, and Analytical Aspects in the Aqueous System

Gottardi

1999

Arch. Pharm. Pharm. Med. Chem.

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Disinfectants

Harke¹

2000

Ullmann's Encyclopedia of Industrial Chemistry

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Disinfectants

Siebert¹,

Harke²

2009

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 2. Definitions 3. Application 4. Efficacy Testing Methods, Requirements for Efficacy 5. Formulations 6. Active Ingredients 6.1. Alcohols 6.2. Aldehydes 6.3. Peroxy and Peroxo Acids 6.4. Phenols 6.5. Cation‐Active Compounds 6.6. Amphoteric Compounds 6.7. Alkylamines 6.8. Inorganic Compounds 7. Toxicology

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Physikalisch-chemische Grundlagen der mikrobiziden Wirkung wäßriger PVP-Jod-Lösungen

Cited by 3 publications

References 22 publications

Iodine and Disinfection: Theoretical Study on Mode of Action, Efficiency, Stability, and Analytical Aspects in the Aqueous System

Iodine and Disinfection: Theoretical Study on Mode of Action, Efficiency, Stability, and Analytical Aspects in the Aqueous System

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