Phytochemical analysis and antioxidant activity of Mezzetia parviflora Becc. Woodbark extract

Murdifin, Mufidah; Wahyudin, Elly; Lawrence, Gatot Susilo; Subehan,; Manggau, Marianti A.; Alam, Gemini

doi:10.5530/pj.2012.34.3

Cited by 4 publications

(2 citation statements)

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“…18,19 The concentration of each sample required for 50% scavenging of the DPPH free radical (IC 50 ) was interpolated from the linear equation.…”

Section: % Radical Scavenging = (A Control -A Sample ) X100/a Controlmentioning

confidence: 99%

Anti-Tyrosinase and DPPH Radical Scavenging Activities of Selected Thai Herbal Extracts Traditionally Used as Skin Toner

Sungthong¹,

Phadungkit²

2015

Phcog J

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Introduction: Skin darkness may be cosmetically undesirable for some people. Plant-derived materials traditionally used for skin lightening may produce satisfactory results. Besides innate tyrosinase activity, oxidative stress also plays an important role in skin darkness by activating tyrosinase. Therefore, herbal extracts with strong anti-tyrosinase and antioxidant activities could be considered as efficacious skin lightening agents. The aims of the present study were to determine the anti-tyrosinase and antioxidant activities of Thai medicinal plant extracts indigenously used as skin toners. Methods: The activities of seven Thai medicinal plants; Zingiber cassumunar Roxb., Phyllanthus emblica Linn., Tagetes erecta Linn., Centella asiatica, Raphanus sativusvar. Longipinnatus Linn., Cassia fistula Linn. and Butea monosperma (Lam.) Taub. were investigated using the DOPA-chrome method to determine anti-tyrosinase activity and the DPPH free radical scavenging assay to determine antioxidant activity. Results: With respect to tyrosinase inhibitory activity, P. emblica, B. monosperma and R. sativusvar. Longipinnatus extracts at a concentration of 1.67 mg/mL showed strong activities with the percentage of tyrosinase inhibition at 48.38±4.77, 46.92±3.77 and 42.85±6.54%, respectively. In addition, P. emblica and B. monosperma extracts also exhibited high antioxidant activities with the IC 50 values on 33.47±1.24 and 33.57±1.92 mg/mL, respectively. Conclusion: Based on tyrosinase inhibition activity and DPPH radical scavenging assays, the herbal extracts of P. emblica and B. monosperma show promise as potential skin lighteners in cosmetic formulations.

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“…18,19 The concentration of each sample required for 50% scavenging of the DPPH free radical (IC 50 ) was interpolated from the linear equation.…”

Section: % Radical Scavenging = (A Control -A Sample ) X100/a Controlmentioning

confidence: 99%

Anti-Tyrosinase and DPPH Radical Scavenging Activities of Selected Thai Herbal Extracts Traditionally Used as Skin Toner

Sungthong¹,

Phadungkit²

2015

Phcog J

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“…High percentage of antioxidant activity related to phenolic condensed tannin in acetone extract that is 26.46 ± 0.315 mg/mg of the extract (calculated as quebracho tannin). 12 This research conducted to evaluate lipid anti-peroxidation activity of Mezzetia parviflora Becc. Wood bark polar extract.…”

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation Inhibitory Activity In vitro of Mezzetia parviflora Becc. Wood Bark Polar extract

Murdifin¹,

Pakki²,

Alam³

et al. 2017

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Introduction:The wood bark of Mezzetia parviflora Becc, has long served as one of the most important traditional herbal medicine sources in Buton Regency, Southeast Sulawesi. M. parviflora extracts were rich in polyphenols. This study was aimed to explore the lipid peroxidation inhibitory activity of polar extract of M. parviflora. Methods: The polar extract is the result of ethanol extract partition solved in acetone. The extract will keep polar components which are insoluble in acetone. Assayed methods applied are ß-carotene bleaching inhibition, thiobarbituric acid reactive substance (TBARS) measurement, and continuous monitoring of conjugated dienes formation in LDL. Results: M. parviflora extract inhibit ß-carotene/ linoleic acid oxidation, showed by IC50 value of 15.83 µg/ml in 30th minute; but the potency will be reduced to IC50 value of 111.19 µg/ml and 225.07 µg/ml after the 60th and 120th minute of incubation. M. parviflora extract inhibit MDA formation as for linoleic acid peroxidation product until the third day; at 20, 40, 60, 80 and 100 µg/ml inhibit MDA formation as many as 29.16 ± 2.41%, 4.24% ± 43.27, 54.08 ± 2.87%, 59.88 ± 1.90%, and 69.75 ± 2.32%, respectively. M. parviflora extract at 50 µg/ml can inhibit LDL-oxidation induced by CuSO4, performed by LDL-oxidation lag-time elongation until 70 minutes, similar ability was performed by epigallocathecin gallate at 5 µg/ml. Conclusions: M. parviflora extract expressed relatively strong protection against lipid and LDL oxidation which can serve as the scientific basis of its development as a remedy for various diseases caused by lipid peroxidation.

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Cytotoxic activity and phytochemical standardization of Lunasia amara Blanco wood extract

Zubair

Anam

Lallo

2016

Asian Pacific Journal of Tropical Biomedicine

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Phytochemical analysis and antioxidant activity of Mezzetia parviflora Becc. Woodbark extract

Cited by 4 publications

References 10 publications

Anti-Tyrosinase and DPPH Radical Scavenging Activities of Selected Thai Herbal Extracts Traditionally Used as Skin Toner

Anti-Tyrosinase and DPPH Radical Scavenging Activities of Selected Thai Herbal Extracts Traditionally Used as Skin Toner

Lipid Peroxidation Inhibitory Activity In vitro of Mezzetia parviflora Becc. Wood Bark Polar extract

Cytotoxic activity and phytochemical standardization of Lunasia amara Blanco wood extract

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