Phytochemical and Pharmacological Studies of Dalbergia sissoo Growing in Egypt

Sarg, Taha; Ateya, Abdel-Monem; Abdel-Ghani, Afaf; Badr, Wafaa; Shams, Gamal

doi:10.1076/phbi.37.1.54.6310

Cited by 15 publications

(21 citation statements)

References 6 publications

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“…Isoflavones, biochanin-A, muningin, sissotrin, amyrin, stigmasterol have been isolated from the aerial parts of Dalbergia sissoo Roxb [11]. The stem-bark has been reported to contain dalberjenone, dalbergin and methyl dalbergin and a new 4-phenyl chromene, dalbergichromene [12].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Mannan

Khatun

Khan

2017

BMC Complement Altern Med

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Background Dalbergia sissoo DC. (Family: Fabaceae) is a medium to large deciduous tree, is locally called “shishu” in Bangladesh. It is used to treat sore throats, dysentery, syphilis, bronchitis, inflammations, infections, hernia, skin diseases, and gonorrhea. This study evaluated the antinociceptive effect of the methanol extract of D. sissoo leaves (MEDS) in mice.MethodsThe extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p.o.) respectively. Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i.p.) were used as reference analgesic drugs. To confirm the possible involvement of opioid receptor in the central antinociceptive effect of MEDS, naloxone was used to antagonize the effect.ResultsMEDS demonstrated potent and dose-dependent antinociceptive activity in all the chemical and heat induced mice models (p < 0.001). The findings of this study indicate that the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone verified the association of opioid receptors in the central antinociceptive effect.ConclusionsThis study indicated the peripheral and central antinociceptive activity of the leaves of D. sissoo. These results support the traditional use of this plant in different painful conditions.

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Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Mannan

Khatun

Khan

2017

BMC Complement Altern Med

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“…Compound 19 was identified for the first time from C. morifolium in the present study. It has been isolated from the leaves and stems bark of Dalbergia spinose and has been related to anti-inflammatory activity [40]. Since current treatment of gout include the use of anti-inflammatory agent, compound 17 and 19 could be investigate further as a lead compound for gout therapy.…”

Section: Putative Identification Of Xo Inhibitors Using Hplc-q-tof-ms/msmentioning

confidence: 99%

In vitro and in vivo inhibition of xanthine oxidase by the flowers of Chrysanthemum morifolium Ramat.

Ng¹,

Loh²,

Tan³

et al. 2020

Preprint

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Background: Xanthine oxidase (XO) plays an important role in human’s purine degradation. Excessive uric acid formation results in hyperuricemia and gout. The study aimed to determine the XO inhibitory potential of Chrysanthemum morifolium Ramat. dried flower and its effect on XO gene expression in animal models.Methods: In vitro XO inhibitory assay was employed to investigate the XO inhibitory potential of C. morifolium flowers. The bioactive sub-fraction was investigated further to give additional insight on its uric acid lowering potential via animal study and XO gene expression analysis. HPLC-Q-TOF-MS/MS was utilized to identify the putative compounds in the sub-fraction.Results: Among the fractions, EtOAc fraction exhibited the highest in vitro XO inhibitory potency (51.77 ± 0.98%; IC50 = 10.64 ± 0.51 µg/mL) and it was further fractionated into 15 sub-fractions through open column chromatography. EtOAc F7, F8, F9, F10, and F11 possessed >75% XO inhibition. F9 and F10 exhibited high in vitro XO inhibitory activity, cellular pro-proliferative effect and intracellular antioxidant activity among the sub-fractions tested. These two sub-fractions were also non-cytotoxic at the concentration range of 0.1 – 10 µg/mL. F10 was shown to be very effective in both serum and urine uric acid lowering properties in rats model upon oral consumption. It was subjected to further fractionation and a total of 11 sub-fractions were obtained. F10-4, F10-8, F10-9, and F10-10 possessed >90% XO inhibition. These sub-fractions were subjected to HPLC-Q-TOF-MS/MS analysis. A total of nine known compounds have been identified and 26 unknown compounds were detected. Conclusions: The possible mechanisms contributed to the anti-hyperuricemic effect of F10 were suggested to be non-competitive inhibition of XO enzyme, XO gene expression down regulation, and enhancement of uric acid excretion. Structure elucidation of the unknown compounds and the evaluation of the XO inhibitory activity of a single or a mixture of these compounds are recommended to identify possible synergism between them.

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“…Several authors have reported that an extract particularly from aerial parts of D. sissoo is used significantly for antipyretic, analgesic, and estrogen-like activities (Sarg et al, 1999). It has also reported its pharmacological properties in stimulation of new cell growth and tissue regeneration (Hajare et al, 2001).…”

Section: Sisoo (Delbergia Sissoo)mentioning

confidence: 99%

Ex-situ conservation of medicinal Plants and its therapeutic in mine impacted lands in dry tropical forests of Jharkhand, India

Singh¹,

Ansari²,

Singh³

et al. 2017

Eurasian Journal of Forest Science

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Medicinal plant plays a crucial role in the socioeconomic development and maintaining the human health and culture. Naturally, plant-derivative drugs have an imperative position in both traditional and modern medicine. Jharkhand is rich in biodiversity of medicinal plants. The forest area covers about 30.29% of the total area of Jharkhand. The extensive use of such medicinal plants is nowadays being adopted by almost all the developing and developed countries as therapeutic purpose. It is used to heal various diseases and also prevents the ill effects of synthetic drugs. The main objectives of this article are to identify selected native medicinal properties found in the native forest of Jharkhand and maintain the plants under ex-situ conservation Park for socioeconomic development of the tribal which has been used for multipurpose curative applications and their value addition for different diseases. In the current article a total of 41medicinal plants have been selected for study and documented to their therapeutic use against various types of diseases frequently occurred in tribal dominating mining areas at coal capital of the country located at CSIR-CIMFR, Dhanbad in Jharkhand state of India.

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Phytochemical and Pharmacological Studies of Dalbergia sissoo Growing in Egypt

Cited by 15 publications

References 6 publications

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice

In vitro and in vivo inhibition of xanthine oxidase by the flowers of Chrysanthemum morifolium Ramat.

Ex-situ conservation of medicinal Plants and its therapeutic in mine impacted lands in dry tropical forests of Jharkhand, India

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