Phytochemical study of leaves of Ocotea caudata from Colombia

Abstract

This first phytochemical study of leaves of Ocotea caudata led to the isolation of ten isoquinoline alkaloids, one of them previously unreported, S-(+)-9-O-demethylnorpreocoteine (1), three known flavonoids, two phenols, two eudesmane type sesquiterpenoids, one proline derivative, one fatty alcohol and a phytosterol. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analyses including HSQC, HMBC, H-H COSY, NOESY, as well as HRESIMS data in addition to comparison with reports in the literature.

Rapid structural characterisation of benzylisoquinoline and aporphine alkaloids from Ocotea spixiana acaricide extract by HPTLC‐DESI‐MSn

“…Ocotea is an expressive genus of the Lauraceae family, occurring mainly in tropical and subtropical areas 1 . Species of this genus are known for producing a variety of secondary metabolites, with neolignans, aporphine and benzylisoquinoline‐type alkaloids as the most representative classes 2,3 . A wide range of biological activities from Ocotea species has been described in the literature, including acaricide, 4,5 antiproliferative, 6 anti‐inflammatory 7 and the inhibition of acetylcholinesterase (AChE) 8 …”