Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from<i>Thymus Algeriensis</i>

Mokhtari, Mouna; Chabani, Sonia; Mouffouk, Soumia; Aberkane, M. C.; Dibi, Ammar; Benkhaled, Mohammed; Haba, Hamada

doi:10.1080/10496475.2021.1891174

Cited by 11 publications

(21 citation statements)

References 18 publications

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“…It has been shown to be able to deliver drugs in the brain efficiently. Our results have shown that this compound can improve the efficiency of brain targeting of mixed nanoparticles, and it is also an anti-inflammatory [21]. The percentage of borneol obtained in the studied samples was from 11.16% to 17.13%, and it was noticed that this element percentage is less than that of camphor for the same targeted parts and period collection.…”

Section: Figurementioning

confidence: 62%

Biological Properties of Essential Oils from Thymus algeriensis Boiss

Ouakouak

Benarfa

Messaoudi

et al. 2021

Plants

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This study describes the chemical composition, antitumor, antioxidant, and antimicrobial activities of the plant Thymus algeriensis Boiss. Essential oils (EOs) were collected in different periods (before, during, and after flowering stage) from the El-Guetfa region, M’sila, Algeria. The EOs extraction was achieved using three distinguishing techniques: hydro (Clevenger trap), steam, and microwave distillations, targeting different aerial parts of the plant (stems, flowers, and leaves). The EOs chemical components were estimated using GC-FID and GC-MS apparatuses. The resulting yield of the extracted oil was moderate and ranged between 0.84 and 1.53% (wt/vol). In total, eighty-five components were identified, in which the oxygenated monoterpenes family formed the main portion, starting from 40.56 up to 70.66%. The obtained essential oil was dominated by five major components that varied from low to quite moderate percentages: camphor (17.45–32.56%), borneol (11.16–22.2%), camphene (7.53–12.86%), 1.8-cineole (5.16–11.21%), and bornyl acetate (3.86–7.92%). The biological results of this oil pointed out that the EOs extracted from the leaves part exposed a weak radical scavenging activity afterward using two well-known antioxidant assays DPPH (IC50 = 8.37 mg/mL) and ABTS (10.84 mg/mL). Meanwhile, this oil presented strong inhibition activity against colon cancer cell line HCT116 (LC50 = 39.8 µg/mL) and a moderate inhibitory against hepatocellular cancer cells HePG2 (LC50 > 100 µg/mL). In addition, this oil antimicrobial activity was quite important against Micrococcus luteus (M. luteus), Staphylococcus aureus CIP 7625, Escherichia coli ATCC 10536, Saccharomyces cerevisiae ATCC 4226, Candida albicans IPA200, Candida tropicalis (Ct), and Candida glabrata (Cg) after using Amoxicillin and Itraconazole as references.

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Section: Figurementioning

confidence: 62%

Biological Properties of Essential Oils from Thymus algeriensis Boiss

Ouakouak

Benarfa

Messaoudi

et al. 2021

Plants

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“…The only study on the antioxidant potential of EO from T. algeriensis stem bark was conducted in Algeria and showed that the plant exhibited moderate DPPH scavenging activity (IC 50 = 83.8 mg/mL) [ 30 ]. Furthermore, Mokhtari et al [ 44 ] tested the antioxidant activities of other different extracts and showed that, using the DPPH assay, chloroform, petroleum ether, and n–BuOH extracts demonstrated IC 50 values of 79.92 ± 0.30, 69.50 ± 0.68, and 5.05 ± 0.12 μ g/mL, respectively. Noteworthy, the antioxidant potential of all these extracts was dependent on the method used.…”

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

“…Recently, Mokhtari et al [ 44 ] showed that petroleum ether, chloroform, and n–BuOH extracts from the aerial parts of Algerian T. algeriensis inhibited egg albumin denaturation in a concentration-dependent effect. The highest inhibitory effect was observed using the chloroform extract with 45.27% inhibition, followed by petroleum ether (30.26%) and then n–BuOH (26.03%) extracts [ 44 ]. This activity could be useful in inhibiting protein denaturation during inflammatory conditions characterized by the production of autoantigens during disorder conditions such as rheumatic arthritis, cancer, and diabetes [ 60 ].…”

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

“…The highest antihemolytic effect was noted using the n–BuOH extract (IC 50 = 322.85 ± 0.87 μ g/mL), followed by the chloroform extract (IC 50 = 443.25 ± 0.52 μ g/mL). The petroleum ether extract displayed the lowest activity with 19.51% inhibition at 800 μ g/mL [ 44 ]. The antihemolytic effect of T. algeriensis extracts could be linked to their chemical composition, particularly flavonoids and polyphenols.…”

Section: In Vitro Pharmacological Propertiesmentioning

confidence: 99%

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Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

Mahdi

Bakrim

Bitchagno

et al. 2022

Oxidative Medicine and Cellular Longevity

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Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant-derived compounds/molecules are being introduced into the market. The medicinal plants belonging to the genus Thymus are among the most important species within the Lamiaceae family. One of them is Thymus algeriensis which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of T. algeriensis extracts. Data were obtained using electronic databases such as SciFindern, ScienceDirect, Scopus, and Web of Science. Several plant-based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action. T. algeriensis represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of T. algeriensis into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of T. algeriensis and derived compounds in health maintenance and promotion and disease prevention.

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