Pig Kidney: Anatomical Relationships Between the Intrarenal Arteries and the Kidney Collecting System. Applied Study for Urological Research and Surgical Training

Pereira‐Sampaio, Marco A.; Favorito, Luciano A.; Sampaio, Francisco J.B.

doi:10.1097/01.ju.0000138085.19352.b5

Cited by 106 publications

(115 citation statements)

References 21 publications

(36 reference statements)

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“…Although the swine is the most adequate model for comparison to human kidney anatomy and physiology 13,21 , this is still an experimental setting and different from the clinical setting. Further, these animals were healthy individuals, without renal tumor or any other medical condition which, again, does not represents the patients submitted to partial nephrectomy.…”

Section: Resultsmentioning

confidence: 99%

Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model

et al. 2016

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PURPOSE:To evaluate the glomerular loss after arteriovenous or arterial warm ischemia in a swine model. METHODS:Twenty four pigs were divided into Group Sham (submitted to all surgical steps except the renal ischemia), Group AV (submitted to 30 minutes of warm ischemia by arteriovenous clamping of left kidney vessels), and Group A (submitted to 30 minutes of ischemia by arterial clamping). Right kidneys were used as controls. Weigh, volume, cortical volume, glomerular volumetric density (Vv[Glom]), volume-weighted glomerular volume (VWGV), and the total number of glomeruli were measured for each organ. RESULTS:Group AV showed a 24.5% reduction in its left kidney Vv[Glom] and a 25.4% reduction in the VWGV, when compared to the right kidney. Reductions were also observed when compared to kidneys of sham group. There was a reduction of 19.2% in the total number of glomeruli in AV kidneys. No difference was observed in any parameters analyzed on the left kidneys from group A. CONCLUSIONS:Renal warm ischemia of 30 minutes by arterial clamping did not caused significant glomerular damage, but arteriovenous clamping caused significant glomerular loss in a swine model. Clamping only the renal artery should be considered to minimize renal injury after partial nephrectomies.

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Section: Resultsmentioning

confidence: 99%

Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model

et al. 2016

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“…However, two or more branches have been reported in the dog (Christensen 1952;Khamanarong et al 2004), while it was reported that the primary division of the pig renal artery forms a cranial and a caudal branch in 93.4% of cases (Pereira-Sampaio et al 2004). Similar to reports in rats (Fuller and Huelke 1973) and dogs (Khamanarong et al 2004;MarquesSampaio et al 2007), we observed the dorsal and ventral branches of renal arteries to be divided as cranial and a caudal segmental arteries.…”

Section: Discussionmentioning

confidence: 99%

Macroscopic distribution of the renal artery and intrarenal arteries in mole rats (Spalax leucodon)

Yoldaş¹,

Aydın²,

Ilgün³

2014

Vet. Med. - Czech

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ABSTRACT:A study was conducted of the kidneys of adult mole rats (Spalax leucodon) to describe the macro-and mesoscopic morphology of the renal arterial distribution and some additional anatomical features. The kidneys of the mole rat lay alongside the vertebral column in the abdominal region, the right kidney situated more cranial than the left. Covered by a thin connective tissue capsule, the kidney was bean-shaped, smooth, and reddish-brown. The mean live weight of the studied mole rats was 203.6 ± 15.05 g. The mean kidney weight was 0.636 ± 0.048 g. The mean weight of the right kidney (0.641± 0.039 g) was significantly (P < 0.01) heavier than that of the left one (0.630 ± 0.057g). Sixteen three-dimensional endocasts of the renal artery and intrarenal arteries were prepared using standard injection-corrosion techniques and examined. A single renal artery was observed in 100% of the specimens. The renal arteries divided, forming a dorsal and a ventral branch; these bifurcated forming cranial and caudal segmental branches. No anastomoses were observed between any of these branches.

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“…Although the pig model is the most similar to human anatomy and physiology 15,29 , this is still an experimental setting and different from the clinical setting. These animals were healthy, without renal tumors or any other medical condition.…”

Section: ■ Discussionmentioning

confidence: 99%

The relationship between renal warm ischemia time and glomerular loss. An experimental study in a pig model

et al. 2017

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The relationship between renal warm ischemia time and glomerular loss. An experimental study in a pig model 1 Acta Cir. Bras. 2017;32(5):334-341 Abstract Purpose: To investigate the glomerular number after different warm ischemia times. Methods: Thirty two pigs were assigned into four groups. Three groups (G10, G20, and G30) were treated with 10, 20, and 30 minutes of left renal warm ischemia. The sham group underwent the same surgery without renal ischemia. The animals were euthanized after 3 weeks, and the kidneys were collected. Right kidneys were used as controls. The kidney weight, volume, cortical-medullar ratio, glomerular volumetric density, volume-weighted mean glomerular volume, and the total number of glomeruli per kidney were obtained. Serum creatinine levels were assessed pre and postoperatively. Results: Serum creatinine levels did not differ among the groups. All parameters were similar for the sham, G10, and G20 groups upon comparison of the right and left organs. The G30 group pigs' left kidneys had lower weight, volume, and cortical-medullar ratio and 24.6% less glomeruli compared to the right kidney. A negative correlation was found between warm ischemia time and glomerular number. Conclusions: About one quarter of glomeruli was lost after 30 minutes of renal warm ischemia. No glomeruli loss was detected before 20 minutes of warm ischemia. However, progressive glomerular loss was associated with increasing warm ischemia time.

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Pig Kidney: Anatomical Relationships Between the Intrarenal Arteries and the Kidney Collecting System. Applied Study for Urological Research and Surgical Training

Abstract: Although the results of renal and intrarenal anatomy in pigs could not be completely transposed to humans, many similarities in the pig and human intrarenal arteries support its use as the best animal model for urological procedures.

Cited by 106 publications

References 21 publications

Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model

Glomerular loss after arteriovenous and arterial clamping for renal warm ischemia in a swine model

Macroscopic distribution of the renal artery and intrarenal arteries in mole rats (Spalax leucodon)

The relationship between renal warm ischemia time and glomerular loss. An experimental study in a pig model

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