Plant Derived Bioactive Molecules: Culture Vessels to Bioreactors

An optimized biotechnological system for the production of centellosides based on elicitation and bioconversion of Centella asiatica cell cultures

“…Thus, plant cell factories have emerged as a realistic technology for the production of bioactive components of medicines and cosmetics, including high added value products such as shikonin, arbutine, and taxol . In recent years, a number of cosmetic companies have also begun to use plant cell cultures, referred to as “plant stem cells,” directly as cosmetic ingredients, thus expanding the role of this technology.…”

“…Correspondence: Dr. Javier Palazon (javierpalazon@ub.edu), Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, 08028 Barcelona, Spain Abbreviations: CFW, cell fresh weight; CORO, coronatine; GI, growth index; MeJA, methyl jasmonate; MER, Manila elemi resin; SA, salicylic acid; YE, yeast extract Thus, plant cell factories have emerged as a realistic technology for the production of bioactive components of medicines and cosmetics, including high added value products such as shikonin, arbutine, and taxol [2]. In recent years, a number of cosmetic companies have also begun to use plant cell cultures, referred to as "plant stem cells," directly as cosmetic ingredients, thus expanding the role of this technology.…”

Biomass Production of Gynura procumbens Adventitious Roots in Different Type of Liquid Culture

“…Immersion time is a critical factor for root cultures and over lodging can cause hyperhydricity. Inoculum size can also affect the productivity, in which too many tissue mass formulated can cause problems during scaling up (Sharma et al, 2014).…”

Mass Propagation of Plant Cells – An Emerging Technology Platform for Sustainable Production of Biopharmaceuticals

“…; cardioprotective triterpene saponins mix Ginseng from Panax ginseng; tyrosinase inhibitor arbutin from Catharanthus roseus; and immunostimulant polysaccharides from Echinaceae spp. [13,14]. A breakthrough in commercialization of PCCT has been made with adaptation of technology for production of bioactive phytochemicals and plant cell biomass used as active cosmetic ingredients, where the natural origin and the lack of genetic modifications are of special importance for consumers [15,16].…”

“…However, PCCT still have some limitations that slowed down its scale-up and commercial realization. The main speed breakers are the low and variable yields of targeted biopharmaceutical and the high level of somaclonal variability of production clones, which results in product loss and reduce the economic feasibility of the process [14]. To address the above limitations, cambial meristematic cell (CMC) cultures have been developed and adapted for production of biopharmaceutical [18].…”