Plant‐mediated synthesis of silver‐doped zinc oxide nanoparticles and evaluation of their antimicrobial activity against bacteria cause tooth decay

Mortezagholi, Bardia; Movahed, Emad; Fathi, Amirhossein; Mirhosseini, Armita Forutan; Zeini, Negar; Khatami, Mehrdad; Naderifar, Mahin; Kiasari, Bahman Abedi; Zareanshahraki, Mehran

doi:10.1002/jemt.24207

Cited by 36 publications

(12 citation statements)

References 175 publications

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“…It is a very significant medicinal plant with well-known therapeutic potential. Green synthesis is the most effective way when compared to physical and chemical methods [42]. Both synthesis processes, despite their efficiency, have some shortcomings, for example, high costs, high energy needs, and the creation of toxic hazardous waste materials [43].…”

Section: Synthesis Of Ag 2 Onpsmentioning

confidence: 99%

Biogenic Synthesis of Multifunctional Silver Oxide Nanoparticles (Ag2ONPs) Using Parieteria alsinaefolia Delile Aqueous Extract and Assessment of Their Diverse Biological Applications

et al. 2023

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Green nanotechnology has made the synthesis of nanoparticles a possible approach. Nanotechnology has a significant impact on several scientific domains and has diverse applications in different commercial areas. The current study aimed to develop a novel and green approach for the biosynthesis of silver oxide nanoparticles (Ag2ONPs) utilizing Parieteria alsinaefolia leaves extract as a reducing, stabilizing and capping agent. The change in color of the reaction mixture from light brown to reddish black determines the synthesis of Ag2ONPs. Further, different techniques were used to confirm the synthesis of Ag2ONPs, including UV-Visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), zeta potential and dynamic light scattering (DLS) analyses. The Scherrer equation determined a mean crystallite size of ~22.23 nm for Ag2ONPs. Additionally, different in vitro biological activities have been investigated and determined significant therapeutic potentials. Radical scavenging DPPH assay (79.4%), reducing power assay (62.68 ± 1.77%) and total antioxidant capacity (87.5 ± 4.8%) were evaluated to assess the antioxidative potential of Ag2ONPs. The disc diffusion method was adopted to evaluate the antibacterial and antifungal potentials of Ag2ONPs using different concentrations (125–1000 μg/mL). Moreover, the brine shrimp cytotoxicity assay was investigated and the LC50 value was calculated as 2.21 μg/mL. The biocompatibility assay using red blood cells (<200 μg/mL) confirmed the biosafe and biocompatible nature of Ag2ONPs. Alpha-amylase inhibition assay was performed and reported 66% inhibition. In conclusion, currently synthesized Ag2ONPs have exhibited strong biological potential and proved as an attractive eco-friendly candidate. In the future, this preliminary research work will be a helpful source and will open new avenues in diverse fields, including the pharmaceutical, biomedical and pharmacological sectors.

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Section: Synthesis Of Ag 2 Onpsmentioning

confidence: 99%

Biogenic Synthesis of Multifunctional Silver Oxide Nanoparticles (Ag2ONPs) Using Parieteria alsinaefolia Delile Aqueous Extract and Assessment of Their Diverse Biological Applications

et al. 2023

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“…Current research in the biosynthesis of nanometals using plants has started a new era for the production of nanoparticles with fast and non‐toxic methods (Ali et al, 2022; Mortezagholi et al, 2022; Saravanan et al, 2018). Plants (especially plant extracts) can reduce metal ions (Akbarizadeh et al, 2022; Sadeghi, Alijani, et al, 2022; Vidhya et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Apoptotic, cytotoxic, antioxidant, and antibacterial activities of biosynthesized silver nanoparticles from nettle leaf

Dağlioğlu

Öztürk

Khatami

2023

Microscopy Res & Technique

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Here, we reported the biosynthesis of silver nanoparticles (AgNPs) using Urtica dioica (nettle) leaf extract as green reducing and capping agents and investigate their anticancer and antibacterial, activity. The Nettle‐mediated biosynthesized AgNPs was characterized by UV–Vis a spectrophotometer. Their size, shape and elemental analysis were determined with the using of SEM and TEM. The crystal structure was determined by XRD and the biomolecules responsible for the reduction of Ag+ were determined using FTIR analysis. Nettle‐mediated biosynthesis AgNPs indicated strong antibacterial activity against pathogenic microorganisms. Again, the antioxidant activity of AgNPs is quite high when compared to ascorbic acid. Anticancer effect of AgNPs, IC50 dose was determined by XTT analysis using MCF‐7 cell line and the IC50 value was found to be 0.243 ± 0.014 μg/mL (% w/v).

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“…Active nanotech-based research has yielded several new advancements with wide-ranging applications [ 14 , 15 ]. New therapeutic efforts have been concentrated on the design of nanocarriers like polymeric nanoparticles [ 16 , 17 ], inorganic nanoparticles [ 18 , 19 , 20 , 21 ], green synthesized NPs [ 22 , 23 , 24 ], liposomes [ 25 ], nanofibers [ 26 ], hydrogels [ 27 , 28 , 29 ], Niosomes [ 30 , 31 , 32 ], and microemulsions [ 33 , 34 ] to transport therapeutic and diagnostic agents. In light of this fact, the above-mentioned nanoparticles (NPs) have attracted much attention thanks to their relatively high drug loading ability, lower or no systematic toxicity, controlled drug release, extended blood circulation time, capability of targeted delivery, and physical–chemical stability [ 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform

et al. 2023

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The blood–brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) against drugs that enter the bloodstream. The BBB is a key clinical barrier in the treatment of CNS illnesses because it restricts drug entry into the brain. To bypass this barrier and release relevant drugs into the brain matrix, nanotechnology-based delivery systems have been developed. Given the unstable nature of NPs, an appropriate amount of a biocompatible polymer coating on NPs is thought to have a key role in reducing cellular cytotoxicity while also boosting stability. Human serum albumin (HSA), poly (lactic-co-glycolic acid) (PLGA), Polylactide (PLA), poly (alkyl cyanoacrylate) (PACA), gelatin, and chitosan are only a few of the significant polymers mentioned. In this review article, we categorized polymer-coated nanoparticles from basic to complex drug delivery systems and discussed their application as novel drug carriers to the brain.

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Plant‐mediated synthesis of silver‐doped zinc oxide nanoparticles and evaluation of their antimicrobial activity against bacteria cause tooth decay

Cited by 36 publications

References 175 publications

Biogenic Synthesis of Multifunctional Silver Oxide Nanoparticles (Ag2ONPs) Using Parieteria alsinaefolia Delile Aqueous Extract and Assessment of Their Diverse Biological Applications

Biogenic Synthesis of Multifunctional Silver Oxide Nanoparticles (Ag2ONPs) Using Parieteria alsinaefolia Delile Aqueous Extract and Assessment of Their Diverse Biological Applications

Apoptotic, cytotoxic, antioxidant, and antibacterial activities of biosynthesized silver nanoparticles from nettle leaf

Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform

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