Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus

Telejko, Beata; Kuźmicki, Mariusz; Wawrusiewicz‐Kurylonek, Natalia; Szamatowicz, Jacek; Nikołajuk, Agnieszka; Zonenberg, Anna; Zwierz-Gugala, Dorota; Jelski, Wojciech; Laudański, Piotr; Wilczyński, J; Krętowski, Adam; Górska, Maria

doi:10.1016/j.diabres.2009.10.018

Cited by 64 publications

(52 citation statements)

References 39 publications

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“…Rapidly, apelin went from an overlooked ORF in a lncRNA to a promising biomarker and therapeutic target in cardiovascular diseases, diabetes, and diabetic complications (Castan-Laurell et al 2011O'Carroll et al 2013;Hu et al 2016;Huang et al 2018). Elevated apelinemia was found in obese patients across several studies, which was suggested to be a compensatory mechanism prior to insulin resistance (Boucher et al 2005;Heinonen et al 2005Heinonen et al , 2009Li et al 2006;Castan-Laurell et al 2008;Dray et al 2008Dray et al , 2010Erdem et al 2008;Soriguer et al 2009;Telejko et al 2010). Both shortand long-term apelin treatments in insulin-resistant obese mice were proven to improve insulin sensitivity Castan-Laurell et al 2011;Hu et al 2016).…”

Section: Smorfs: Mrna or Lncrna Orfs Smaller Than 100 Codonsmentioning

confidence: 99%

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

et al. 2018

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Technological advances promise unprecedented opportunities for whole exome sequencing and proteomic analyses of populations. Currently, data from genome and exome sequencing or proteomic studies are searched against reference genome annotations. This provides the foundation for research and clinical screening for genetic causes of pathologies. However, current genome annotations substantially underestimate the proteomic information encoded within a gene. Numerous studies have now demonstrated the expression and function of alternative (mainly small, sometimes overlapping) ORFs within mature gene transcripts. This has important consequences for the correlation of phenotypes and genotypes. Most alternative ORFs are not yet annotated because of a lack of evidence, and this absence from databases precludes their detection by standard proteomic methods, such as mass spectrometry. Here, we demonstrate how current approaches tend to overlook alternative ORFs, hindering the discovery of new genetic drivers and fundamental research. We discuss available tools and techniques to improve identification of proteins from alternative ORFs and finally suggest a novel annotation system to permit a more complete representation of the transcriptomic and proteomic information contained within a gene. Given the crucial challenge of distinguishing functional ORFs from random ones, the suggested pipeline emphasizes both experimental data and conservation signatures. The addition of alternative ORFs in databases will render identification less serendipitous and advance the pace of research and genomic knowledge. This review highlights the urgent medical and research need to incorporate alternative ORFs in current genome annotations and thus permit their inclusion in hypotheses and models, which relate phenotypes and genotypes.

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Section: Smorfs: Mrna or Lncrna Orfs Smaller Than 100 Codonsmentioning

confidence: 99%

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

et al. 2018

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“…18 Another study showed no differences in plasma apelin levels in women with gestational diabetes mellitus and in women with normal glucose tolerance. 19 In the present study we looked for potential differences in plasma apelin and visfatin concentrations between healthy controls and subjects with T1DM. Additionally, we studied the effect of a bolus insulin administration on plasma apelin and visfatin levels during an oral glucose tolerance test (OGTT) in patients with T1DM.…”

Section: Introductionmentioning

confidence: 99%

Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration

Αλεξιάδου¹,

Kokkinos²,

Liatis³

et al. 2012

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OBJEcTIVE. Previous data suggest that apelin and visfatin play a role in metabolism and glucose homeostasis. The aim of the present study was to determine differences in plasma apelin and visfatin concentrations between healthy subjects and patients with type 1 diabetes mellitus and to study the effect of hyperglycemia and insulin administration on their levels in patients with type 1 diabetes mellitus. DEsIGN. One hundred patients with T1DM and 52 healthy subjects were examined. Nine patients with type 1 diabetes and 9 controls participated in a further study. In the main study, blood samples were taken after a 12-hour fast. In a further study, an oral glucose tolerance test was performed on two occasions. In session A, at baseline, insulin lispro (7 units) was administered subcutaneously to the type 1 diabetic patients, while a placebo injection was administered to controls. In session B, no insulin or placebo was administered. Apelin, visfatin, insulin and glucose levels were measured at baseline and 10, 20, 30, 60, 90, 120, 150 and 180 min after glucose consumption. rEsULTs AND cONcLUsIONs. Fasting plasma apelin concentrations were higher (p<0.001), while fasting visfatin levels tended to be lower (p=0.06) in patients with type 1 diabetes in comparison to healthy subjects. In the diabetes group, fasting apelin (but not visfatin) correlated with HDL-c (p=0.001). Apelin and visfatin did not change significantly during the oral glucose tolerance test in either group with or without exogenous insulin administration.

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“…[92] reported a markedly higher maternal plasma apelin level in GDM patients compared to control pregnant women, which positively correlated with its cord blood level. By contrast, Telejko et al [93] demonstrated no association between plasma apelin concentration or apelin/APJ mRNA expression and GDM. Thus, the relationship of this novel adipokine with the pathophysiology of GDM remains to be elucidated.…”

Section: Apelinmentioning

confidence: 95%

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Wójcik¹,

Chmielewska-Kassassir²,

Grzywnowicz³

et al. 2014

Endokrynologia Polska

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Gestational diabetes mellitus (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. The prevalence of GDM is growing rapidly worldwide, resulting in numerous and serious complications for both mother and foetus. Two major metabolic disorders, insulin resistance and β cells dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved in the development of GDM are not yet completely understood. Increasing evidence from clinical and experimental studies indicates that adipose tissue dysfunction, characterised by abnormal production of adipokines, is an essential factor linked to insulin resistance and GDM. To date, several adipose tissue-derived hormones have been identified, including leptin, adiponectin, resistin, visfatin, apelin, retinol-binding protein 4 (RBP-4), vaspin, and omentin. The relationship of leptin and adiponectin to insulin resistance in GDM is relatively well documented, but the molecular mechanisms by which these hormones affect insulin resistance are not yet fully known. The other aforementioned adipokines appear to be also important players in the pathophysiology of GDM, although their precise function in this complex process remains to be established. The aim of this article is to review the literature concerning the relationship between the above-mentioned adipokines and GDM, and to clarify their role in the pathophysiology of GDM. Key words: adipokines; adiponectin; gestational diabetes mellitus (GDM); leptin; omentin; RBP-4; resistin; vaspin; visfatin StreszczenieCukrzyca ciążowa (GDM) jest definiowana jako nietolerancja glukozy, która po raz pierwszy wystąpiła lub została wykryta w czasie ciąży. Zachorowalność na GDM szybko wzrasta na świecie, prowadząc do licznych i poważnych powikłań zarówno u matki, jak i płodu. Dwa główne zaburzenia metaboliczne, czyli oporność na insulinę i dysfunkcja komórek b, biorą udział w patogenezie GDM, jednak komórkowe mechanizmy prowadzące do jej rozwoju nie są jeszcze do końca poznane. Wyniki badań klinicznych i eksperymentalnych wskazują, że dysfunkcja tkanki tłuszczowej, charakteryzująca się nieprawidłową produkcją adipokin, jest istotnym czynnikiem związanym z GDM. Do tej pory zidentyfikowano kilka hormonów wytwarzanych przez tkankę tłuszczową, w tym leptynę, adiponektynę, rezystynę, wisfatynę, apelinę, białko wiążące retinol 4 (RBP-4), waspinę i omentynę. Spośród nich stosunkowo dobrze udokumentowany jest związek leptyny i adiponektyny z insulinoopornością w GDM, ale molekularne mechanizmy działania obydwu hormonów w tym procesie nie są jeszcze całkowicie wyjaśnione. Pozostałe wyżej wymienione adipokiny wydają się być również istotnymi czynnikami w patofizjologii GDM, chociaż ich dokładna funkcja w tym kompleksowym procesie pozostaje niejasna. Celem niniejszego artykułu był przegląd istniejącej literatury dotyczącej związku między wyżej wymienionymi adipokinami i GDM oraz wyjaśnienie ich roli w patofizjologii GDM. (Endokrynol Pol 2014; 65 (2): 1...

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Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus

Cited by 64 publications

References 39 publications

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

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