Plasma GABA-like activity in response to ethanol challenge in men at high risk for alcoholism

Moss, Howard B.; Yao, Jeffrey; Burns, Mark G.; Maddock, John M.; Tarter, Ralph E.

doi:10.1016/0006-3223(90)90529-b

Cited by 22 publications

(4 citation statements)

References 20 publications

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“…Regarding specificity of low pGABA to mood disorders, our earlier research and a recent report (Moss, Burns, Maddock, & Tarter, 1990) suggest an abnormality in GABA function to occur in alcoholism. This need not detract from the finding in mood disorders since a familial as well as pathologic correlation between alcoholism and mood disorders is well established.…”

Section: Bloodmentioning

confidence: 90%

Gaba and Depression

Petty

Kramer

Hendrickse

1993

Biology of Depressive Disorders. Part A

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Section: Bloodmentioning

confidence: 90%

Gaba and Depression

Petty

Kramer

Hendrickse

1993

Biology of Depressive Disorders. Part A

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“…Both genetically and non‐genetically determined deviations in neurochemical functioning appear to contribute to an individual's vulnerability to PSUD. The functioning of a number of neurochemical systems has been reliably found to distinguish individuals who are at high risk for PSUD from those who are at low risk 16,17 …”

Section: Spatial Analysis: Hierarchical Organization Of the Liabilitymentioning

confidence: 99%

Prevention of Drug Abuse

Tarter

1992

American J Addict

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Prevention efforts in alcohol and drug abuse have typically focused on the general population. However, most individuals who abuse addictive drugs either terminate consumption voluntarily or do not progress to a clinical diagnosis of psychoactive substance use disorder (PSUD). Because PSUD has such adverse effects on costs to society, prevention research and practice should emphasize the development and implementation of interventions for individuals who are at high risk for this disorder. This article proposes a conceptual framework for better understanding of the etiology of PSUD and for implementing prevention efforts that are targeted to specific vulnerabilities of an individual. These vulnerabilities are discussed with respect to their spatial organization (i.e., manifestations across multiple levels of biobehavioral organization) and temporal organization (i.e., manifestations across an individual's life span).

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“…There is a significant correlation between cerebrospinal fluid GABA and plasma GABA (Uhlhaas et al 1986). Pharmacological manipulations which change brain GABA levels also change plasma GABA levels in animals (Ferkany et al 1987) and humans (Moss et al 1990). Sodium valproate increased plasma GABA in volunteers (Losher and Schmidt 1980).…”

mentioning

confidence: 96%

“…The origin of GABA in the plasma compartment is controversial (Moss et al 1990), but the major source of plasma GABA appears to be brain, as up to 99 % of total body GABA is in brain and spinal cord. Petty et al (1987) argued that even though the exact contribution from the central nervous system to the peripheral level Correspondence to: R. Balon of neurotransmitters is difficult to estimate, an obvious peripheral source for plasma GABA cannot be demonstrated.…”

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confidence: 99%