Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events

Fuhrmann, Arne; Weingärtner, Oliver; Meyer, Sven; Cremers, Bodo; Seiler-Mußler, Sarah; Schött, Hans-F.; Kerksiek, Anja; Friedrichs, Silvia; Ulbricht, Ursula; Zawada, Adam M.; Laufs, Ulrich; Scheller, Bruno; Fliser, Danilo; Schulze, P. Christian; Böhm, Michael; Heine, Gunnar H.; Lütjohann, Dieter

doi:10.1016/j.atherosclerosis.2018.10.010

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…This indicates that the presence of circulating oxyphytosterols is most likely not an underlying reason for the existing controversy around the potential atherogenicity of elevated plasma plant sterol concentrations (12). Our data are partly in agreement with Fuhrmann et al (25), who did not find an association between absolute and TC-standardized oxyphytosterol concentrations, except for a positive association for 7-OHcampesterol, with cardiovascular events in subjects admitted for elective coronary angiography. While information regarding oxyphytosterol metabolism and their effects on human health is scarce, data from in vitro and animal studies have shown that oxyphytosterols might be atherogenic (5,24).…”

Section: Discussionsupporting

confidence: 91%

Plasma oxyphytosterol concentrations are not associated with CVD status in Framingham Offspring Study participants

Baumgartner

Ras

Trautwein

et al. 2019

Journal of Lipid Research

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Section: Discussionsupporting

confidence: 91%

Plasma oxyphytosterol concentrations are not associated with CVD status in Framingham Offspring Study participants

Baumgartner

Ras

Trautwein

et al. 2019

Journal of Lipid Research

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“…There is no clear explanation for this discrepancy, which might be caused by differences in the background diet of the study population. More recently, Fuhrmann et al [37] and Baumgartner et al [38] showed that the mean POP concentrations in two large cohorts (400‒500 subjects) were 22‒33 nmol/L, which is within the range of the data obtained in our study. These studies [37,38] further showed that none of the investigated POP, except for 7α-OH-campesterol and the 7α-OH-campesterol-to-cholesterol ratio in the Fuhrmann et al [37] study, showed an association with cardiovascular events.…”

Section: Discussionsupporting

confidence: 90%

Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Intake of Oxidized Plant Sterols: A Randomised, Placebo-Controlled, Double-Blind Dose–Response Pilot Study

et al. 2019

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Plant sterols (PS) are oxidized to PS oxidation products (POP). This study quantified the change in serum POP compared to cholesterol oxidation products (COP) after the intake of increasing POP doses. This was a double-blind, randomized, placebo-controlled, dose‒response pilot study with healthy individuals in four groups (15 per group). The control group received products with no added PS or POP and treatment groups received daily 20–25 g margarine with added PS (mean 3 g/d) and two cookies (~28 g) for six weeks. Cookies delivered 8.7 (low-dose), 15.2 (medium-dose), or 37.2 (high-dose) mg/d POP. Fasting serum POP and COP were measured at the baseline, days 14, 28, and 42 in all participants and days 7, 21, and 35 in a subset. Sixty individuals completed the study; 52 were included in per protocol analysis. Serum POP increased with increasing POP intake and plateaued at dose >15 mg/d. Stabilized POP concentrations were (mean ± SD) 38.9 ± 6.9, 91.0 ± 27.9, 144.4 ± 37.9 and 203.0 ± 63.7 nmol/L, for control, low-, medium-, and high-dose POP groups, respectively. For all groups, the serum COP ranged from 213 to 262 nmol/L and the average POP/COP ratio was <1. Serum POP concentrations increased non-linearly, reaching stabilized concentrations in <7 days, and remained below COP concentrations after the intake of increasing POP doses.

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“…Fifth, differences of non-cholesterol sterol values between serum and plasma are a critical issue for clinical laboratory medicine. In some parts of previous papers, plasma samples were used for the measurement of non-cholesterol sterol values 24,26) . However, serum samples, instead of plasma samples, were used in the present study.…”

Section: Advance Publication Journal Of Atherosclerosis and Thrombosismentioning

confidence: 99%

Reference Intervals of Serum Non-Cholesterol Sterols by Gender in Healthy Japanese Individuals

Yoshida

Tada

Ito³

et al. 2020

JAT

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The present study was conducted to establish a practical method for measuring non-cholesterol sterols and reference intervals of serum levels. Methods: Healthy subjects (109 men and 151 women), four patients with sitosterolemia, and 10 heterozygous mutation carriers of ABCG5/ABCG8 genes were investigated. Then, three non-cholesterol sterols (sitosterol, campesterol, and lathosterol) of fasting serum samples were measured via a practical and highly sensitive gas chromatography (GC) method with 0.2 µg/mL as the lower limit of quantification. The coefficient of variation (CV) values for within-run reproducibility were 3.06%, 1.89%, and 1.77% for lathosterol, campesterol, and sitosterol, respectively. The CV values for between-run reproducibility were 2.81%, 2.06%, and 2.10% for lathosterol, campesterol, and sitosterol, respectively. Results: The serum levels of sitosterol and campesterol were significantly higher in women than in men, whereas the serum levels of lathosterol were significantly higher in men than in women. Because of these gender difference, the determination of reference intervals of the three sterol values was performed by considering gender. The reference intervals of sitosterol, campesterol, and lathosterol were 0.99-3.88, 2.14-7.43, and 0.77-3.60 µg/mL in men and 1.03-4.45, 2.19-8.34, and 0.64-2.78 µg/mL in women, respectively. The serum levels of sitosterol and campesterol were higher in patients with sitosterolemia (94.3 47.3 and 66.3 36.6 µg/mL, respectively) than in healthy subjects. Conclusion: These results demonstrate a practical and highly sensitive GC method to measure non-cholesterol sterol levels and gender-segregated reference intervals of sitosterol, campesterol, and lathosterol in Japanese healthy subjects.

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Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events

Cited by 19 publications

References 46 publications

Plasma oxyphytosterol concentrations are not associated with CVD status in Framingham Offspring Study participants

Plasma oxyphytosterol concentrations are not associated with CVD status in Framingham Offspring Study participants

Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Intake of Oxidized Plant Sterols: A Randomised, Placebo-Controlled, Double-Blind Dose–Response Pilot Study

Reference Intervals of Serum Non-Cholesterol Sterols by Gender in Healthy Japanese Individuals

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