Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour?

Abstract

One of the treatments for recurrent or complicated osteomyelitis is by local antibiotherapy mediated by suitable bone grafts. β-Tricalcium Phosphate (β-TCP) bioceramic is a resorbable bone graft. Its microporosity allows for incorporation of drugs, but a too fast release is often obtained. Complex strategies have been explored to obtain controlled drug release. In this work, plasma polymerization of a biocompatible polymer was investigated on β-TCP. Polyethyleneglycol (PEG)-like polymer coatings of different thickness were deposited on microporous β-TCP loaded with antibiotics. A highly hydrophobic surface was obtained despite the hydrophilicity of the PEG-like layer produced, which was associated to the roughness of the β-TCP substrate. The bioceramics nevertheless retained their suitable biological behavior with regard to human osteoblast cells. The microbiological activity of the antibiotics was preserved, and the coatings reduced the total amount of drug released as a function of the increasing plasma treatment time.

Water-Stable Plasma-Polymerized N,N-Dimethylacrylamide Coatings to Control Cellular Adhesion

“…Therefore, extensive surface characterization is required to elucidate the surface properties and chemistry of the resulting plasma-polymerized coatings and to correlate these to the applied parameters in the plasma process. Over the years, the plasma polymerization process of a wide range of precursors has been extensively studied, including carboxylic acids, alcohols, amines, siloxanes, and ethers. − In contrast to these types of monomers, the use of amide-based precursors for plasma deposition has only been reported in a few studies. − Pan et al and Chu et al reported the plasma-assisted synthesis of thermosensitive films based on, respectively, N -isopropylacrylamide (NIPAM) and N , N- diethylacrylamide (DEAM). ,, Cheng et al reported temperature-dependent protein adsorption on plasma coatings based on NIPAM, and Griesser et al observed good cell attachment and growth on films fabricated by plasma polymerization of N , N -dimethylformamide (DMF), N , N -dimethylacetamide (DMA), and N , N -dimethylpropionamide (DMP). , …”

The Effects of Atmospheric Pressure Argon Plasma Treated Bovine Bone Substitute on Bone Regeneration

“…According to the previous study, it was reported that the hydrophobic state of implant biomaterial resulting from the "aging effect" can change to the hydrophilic surface through the ultraviolet (UV) light treatment of aged implants [12,13]. Recently, a number of studies reported that atmospheric pressure plasma (APP) surface treatment can turn a surface hydrophilic and even enhance biocompatibility and cell responses [1,16,17,33,34]. Thus, we expected that the APP treatment can modify the surface of bone graft material by improving surface energy and assumed that such surface treatment can reactivate the expired bone graft material.…”