Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias

White, Eric S.; Xia, Meng; Murray, Susan; Dyal, Rachel; Flaherty, Candace; Flaherty, Kevin R.; Moore, Bethany B.; Cheng, Ling; Doyle, Tracy J.; Villalba, Julian A.; Dellaripa, Paul F.; Rosas, Iván O.; Kurtis, Jonathan D.; Martínez, Fernando J.

doi:10.1164/rccm.201505-0862oc

Cited by 148 publications

(137 citation statements)

References 38 publications

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“…Recently, a biomarker index of SP-D, MMP-7, and osteopontin was found to enhance diagnostic accuracy in IPF patients compared to those with non-IPF interstitial lung diseases [14]. …”

Section: Discussionmentioning

confidence: 99%

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Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis

et al. 2016

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Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology. The pathogenic mechanisms are unclear, but evidence indicates that aberrantly activated alveolar epithelial cells secrete a variety of mediators which induce the migration, proliferation and activation of fibroblasts and finally the excessive accumulation of extracellular matrix with the consequent destruction of the lung parenchyma. CC16 (approved symbol SCGB1A1), a putative anti-inflammatory protein produced by “club” cells in the distal airways, has not been evaluated in IPF lungs. In this study, we determined the serum and bronchoalveolar lavage (BAL) levels as well as the lung cell localization of this protein. Also, we explored the usefulness of serum levels of CC16 for the differential diagnosis of IPF (n = 85), compared with non-IPF interstitial lung diseases [chronic hypersensitivity pneumonitis (cHP; n = 85) and connective tissue diseases (CTD-ILD; n = 85)]. CC16 was significantly increased in serum and BAL fluids of IPF patients and was found not only in club cells but also in alveolar epithelial cells. When compared with non-IPF patients and controls, serum levels were significantly increased (p<0.0001). Sensitivity and specificity for CC16 (cut-off 41ng/mL) were 24% and 90%, positive predictive value 56% and negative predictive value 69%. These findings demonstrate that CC16 is upregulated in IPF patients suggesting that may participate in its pathogenesis. Although higher than the serum levels of non-IPF patients it shows modest sensitivity to be useful as a potential biomarker for the differential diagnosis.

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“…Recently, a biomarker index of SP-D, MMP-7, and osteopontin was found to enhance diagnostic accuracy in IPF patients compared to those with non-IPF interstitial lung diseases [14]. …”

Section: Discussionmentioning

confidence: 99%

“…Recently, a biomarker index composed by SP-D, MMP-7, and osteopontin showed to improve diagnostic accuracy of IPF compared to non-IPF ILD [14]. …”

Section: Introductionmentioning

confidence: 99%

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis

et al. 2016

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“…The versatility of MMP-7 embodies itself a pivotal role in regulating a diverse range of cellular processes, including ECM remodeling and epithelial-mesenchymal transition(EMT) [19, 20]. Not a few studies have reported that upregulation of MMP-7 was found in several fibrosis-related diseases, such as idiopathic pulmonary fibrosis [21], cirrhosis [22]. Moreover, recent publications demonstrated that the renal expression of MMP-7 was enhanced in kidney fibrosis as well, which correlates with β-catenin [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy

Zhang

Ren

Wang

et al. 2017

Kidney Blood Press Res

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Background/Aims: In view of the latest findings that matrix metalloproteinase-7 (MMP-7) acted as a vital marker and pathogenic mediator of renal fibrosis in a murine model, we hypothesized that serum MMP-7 level might serve as a noninvasive prognostic biomarker in IgA nephropathy (IgAN) patients. Methods: We conducted a retrospective follow-up study of 244 IgAN patients for a median of 81.9 months. Serum MMP-7 was detected at the time of diagnosis, and renal progression was assessed by Cox proportional hazards method. Results: Compared with healthy populations, the serum levels of MMP-7 were significantly elevated in IgAN patients. Besides, serum MMP-7 levels were well correlated with renal scarring lesions characterized by glomerular sclerosis and interstitial fibrosis. Follow-up analyses revealed that increased serum MMP-7 levels were linked with a greater risk of poor renal outcome with a hazard ratio of 1.898 per doubling MMP-7 concentration. By contrast with the first quartile, the risk of deterioration in renal function elevated such that the hazard ratio for the second quartile was 1.805, 3.383 for the third, and 5.173 for the fourth quartile of the MMP-7 level. Conclusions: This study showed that the higher serum MMP-7 levels were independently associated with renal fibrosis and poor prognosis in IgAN.

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“…In pulmonary fibrosis or asthmatic patients, serum Postn levels could efficiently predict a worsened outcome or resistance to therapy (41,42). Moreover, plasma levels of OPN cound distinguish subgroups of lung disease patients (72). In terms of therapy, adenoviral CCN5 overexpression or treatment with a blocking antibody against Postn limited collagen deposition in IPF mouse models (18,40).…”

Section: Matricellular Proteins As Biomarkers or Therapeutic Targets mentioning

confidence: 99%

Matricellular Proteins and Organ Fibrosis

Prakoura

Chatziantoniou

2017

Curr Pathobiol Rep

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Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias

Abstract: A biomarker index of SP-D, MMP-7, and osteopontin enhanced diagnostic accuracy in patients with IPF compared with those with non-IPF ILD. Our data suggest that this biomarker index may improve diagnostic confidence in IPF.

Cited by 148 publications

References 38 publications

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis

Serum Matrix Metalloproteinase-7 Level is Associated with Fibrosis and Renal Survival in Patients with IgA Nephropathy

Matricellular Proteins and Organ Fibrosis

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