2011
DOI: 10.1155/2011/860103
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Polonium and Lung Cancer

Abstract: The alpha-radioactive polonium 210 (Po-210) is one of the most powerful carcinogenic agents of tobacco smoke and is responsible for the histotype shift of lung cancer from squamous cell type to adenocarcinoma. According to several studies, the principal source of Po-210 is the fertilizers used in tobacco plants, which are rich in polyphosphates containing radio (Ra-226) and its decay products, lead 210 (Pb-210) and Po-210. Tobacco leaves accumulate Pb-210 and Po-210 through their trichomes, and Pb-210 decays i… Show more

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Cited by 39 publications
(27 citation statements)
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References 90 publications
(113 reference statements)
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“…Mainstream tobacco smoke (exhaled by the smoker) and sidestream smoke (emitted from a burning tobacco product) contain a mixture of human carcinogens, such as benzene, formaldehyde, 1,3 butadiene, polycyclic aromatic hydrocarbons, and polonium (4, 5). Benzene is known to damage cells of myeloid lineage and pluripotent hematopoietic stem cells (6–8), thus potentially playing a role in the development of both childhood AML and ALL.…”
Section: Introductionmentioning
confidence: 99%
“…Mainstream tobacco smoke (exhaled by the smoker) and sidestream smoke (emitted from a burning tobacco product) contain a mixture of human carcinogens, such as benzene, formaldehyde, 1,3 butadiene, polycyclic aromatic hydrocarbons, and polonium (4, 5). Benzene is known to damage cells of myeloid lineage and pluripotent hematopoietic stem cells (6–8), thus potentially playing a role in the development of both childhood AML and ALL.…”
Section: Introductionmentioning
confidence: 99%
“…Besides the environmental exposures to gaseous Rn and its particulate progeny 20 , higher concentrations of 210 Po in smoker's tissues found in our results may be due to 210 Po in fertilizers used to grow tobacco plants 26 . Robert-Csaba Begy et al estimated that approximately 63.41% of tobacco smoke 210 Po reaches the respiratory system 27 , of which about 50% is retained in smoker's lungs 28 .…”
Section: Discussionmentioning
confidence: 55%
“…23 There is now evidence from studies of exposed workers that AML is caused by formaldehyde exposure, particularly in association with high-dose, short-term peaks--an exposure pattern that also describes that of a cigarette smoker. 24,25 None of the other agents controlled under the CAA are known to be a cause of human leukemia, although a leukemogenic effect has been hypothesized for polycyclic aromatic hydrocarbons.…”
Section: Discussionmentioning
confidence: 99%