Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Zhao, Duoyi; Zhu, Tianqi; Li, Jie; Cui, Liguo; Zhang, Zhe; Zhuang, Xiuli; Ding, Jianxun

doi:10.1016/j.bioactmat.2020.08.016

Cited by 276 publications

(187 citation statements)

References 123 publications

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“…Bone defect repair remains a challenge in modern medicine, with substantial social and economic burdens [ 1 ]. Although great progress has been made in research on the use of bioactive scaffolds for bone regeneration in recent years [ 39 ], MSCs and ECs are still considered to be critical for initiating bone healing [ 40 ]. In fact, evidence for the efficacy of MSCs in promoting bone regeneration comes not only from the ability of MSCs to reverse skeletal metabolic diseases but also from the successful application of MSCs in bone tissue engineering and cell therapy [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Tang

Luo

Chen

et al. 2021

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Tang

Luo

Chen

et al. 2021

Bioactive Materials

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“…Due to the advancement of tissue engineering technology, MSC-based regenerative medicine is no longer limited to the direct injection of MSCs into the joint cavity. On the one hand, scaffolds provide the necessary microenvironment and structure for the regeneration process [ [49] , [50] , [51] ]. Scaffold materials mainly include artificial polymeric materials and natural biomaterials [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration

Jiang

Tian

Yang

et al. 2021

Bioactive Materials

117

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Articular cartilage defect repair is a problem that has long plagued clinicians. Although mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they also have many limitations. Recent studies have found that MSC-derived exosomes (MSC-Exos) play an important role in tissue regeneration. The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix (ACECM) scaffold and to explore the underlying mechanism. The results of in vitro experiments show that human umbilical cord Wharton's jelly MSC-Exos (hWJMSC-Exos) can promote the migration and proliferation of bone marrow-derived MSCs (BMSCs) and the proliferation of chondrocytes. We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype. The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model. This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response, which may be a promoting factor for osteochondral regeneration. In addition, microRNA (miRNA) sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage. We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis. In summary, this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.

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“…[ 53,55,56 ] The presence of β‐TCP could help the new tissue growth of PCL scaffolds. [ 39,57–59 ] In addition, nanostructures can effectively enhance the adhesion of cells and bone regeneration, with containing collagen matrix and osteoinductive factors. [ 60 ] Some carriers, like hydrogels, [ 61,62 ] could be used for cells and nano‐DBM in bone tissue engineering in the future.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Study of a Novel Nanoscale Demineralized Bone Matrix Coated PCL/β‐TCP Scaffold for Bone Regeneration

Yuan

Wang

Zhao

et al. 2020

Macromolecular Bioscience

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Bone defects remains a challenge for surgeons. Bone graft scaffold can fill the defect and enhance the bone regeneration. Demineralized bone matrix (DBM) is an allogeneic bone graft substitute, which can only be used as a filling material rather than a structural bone graft. Coating of the scaffolds with nanoscale DBM may enhance the osteoinductivity or osteoconductivity. Herein the lyophilization method is presented to coat the nano‐DBM on surface of the porous polycaprolactone (PCL)/β‐tricalcium phosphate (β‐TCP) scaffolds fabricated by 3D printing technology. The morphology, elastic modulus, in vitro cell biocompatibility, and in vivo performance are investigated. Scanning electron microscope (SEM) shows DBM particle clusters with size of 200–500 nm are observed on scaffolds fibers after coating. MC3T3‐E1 cells on nano‐DBM coated PCL/β‐TCP scaffold show better activity than on PCL/β‐TCP scaffold. In vivo tests show better infiltration of new bone tissue in nano‐DBM coated PCL/β‐TCP scaffold than PCL/β‐TCP scaffold via the interface. These results show the presence of nano‐DBM coating on PCL/β‐TCP scaffold could enhance the attachment, proliferation, and viability of cells and benefit for the new bone formation surrounding and deep inside the scaffolds. Nano‐DBM could potentially be used as a new kind of biomaterial for bone defect treatment.

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Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Cited by 276 publications

References 123 publications

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering

Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration

In Vitro and In Vivo Study of a Novel Nanoscale Demineralized Bone Matrix Coated PCL/β‐TCP Scaffold for Bone Regeneration

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