Polycaprolactone-blended gelatin microspheres and their morphological study

Huda, Muhsina K.; Das, Pranjal Pratim; Baruah, Sanjib; Saikia, Prakash J.

doi:10.1007/s10965-017-1229-0

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…Peak broadening might be due to the lack of proper alignment of the molecules in the composites. 46 Distinctive diffraction peaks for composite film after AgNPs loading observed at 38.16° and 44.56° of 2θ corresponded to (200) and (220) planes of silver confirmed the successful incorporation of AgNPs in the composite films (Figure 4(d)). 47 The average crystallite size of AgNPs was approximately 2.45 nm (Table 5).…”

Section: Resultsmentioning

confidence: 70%

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Akter,

Islam,

Akter

et al. 2024

J Biomater Appl

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Multifunctional and biodegradable dressings with high mechanical strength and good antibacterial activity are crucial in fundamental health services. This study was initiated to prepare a novel curative wound dressing film consisting of natural biodegradable gelatin (G) and polylactic acid (PLA) with silver nanoparticles (AgNPs) where glutaraldehyde (GA) was used as compatibilizer. The prepared composite films addressed the poor thermal and biological stability of G and the limited fluid retention capacity of PLA. Silver nanoparticles were prepared by basic chemical reduction and reinforced on polymer films using simple solvent casting, which obviated common clinical infections and accelerated wound closure rate ( p < .05). Fourier transform infrared (FTIR) studies confirmed composite formation through H-bonding and X-ray diffraction (XRD) revealed increased crystallinity due to incorporating AgNPs. Films with G, PLA & GA (50:50:5 by volume) introduced the best elasticity & strength with excellent fluid retention properties ( p < .05). Scanning electron microscopy (SEM) images unfolded surface morphology and presence of agglomerated AgNPs on film surfaces. Prepared films exhibited significant antimicrobial efficacy against Staphylococcus aureus and Pseudomonas sp. and showed excellent cell viability (>97 %) in Vero cell line. Finally, an in vivo mouse model study showed 99.7 % contraction ( p < .05) within 12 days, which was most effectual and 12 % faster than conventional gauge bandages. These results demonstrated the promising and cost-effective potential of the prepared film for wound healing.

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Section: Resultsmentioning

confidence: 70%

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Akter,

Islam,

Akter

et al. 2024

J Biomater Appl

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“…35 The potential antioxidant property of the CaO 2 @PDA nanoparticles was tested by DPPH assay. 36,37 The characteristic absorption peak of DPPH at 517 nm in the blank group was almost unchanged in 40 min (Fig. 3a).…”

Section: Resultsmentioning

confidence: 96%

Rational design of flexible microneedles coupled with CaO₂@PDA-loaded nanofiber films for skin wound healing on diabetic rats

et al. 2022

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Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery

Nguyen

et al. 2018

J Polym Res

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Polycaprolactone-blended gelatin microspheres and their morphological study

Cited by 9 publications

References 28 publications

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Rational design of flexible microneedles coupled with CaO₂@PDA-loaded nanofiber films for skin wound healing on diabetic rats

Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery

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Polycaprolactone-blended gelatin microspheres and their morphological study

Cited by 9 publications

References 28 publications

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Rational design of flexible microneedles coupled with CaO2@PDA-loaded nanofiber films for skin wound healing on diabetic rats

Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery

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Rational design of flexible microneedles coupled with CaO₂@PDA-loaded nanofiber films for skin wound healing on diabetic rats