Polycyclic aromatic hydrocarbon and its effects on human health: An overeview

Mallah, Manthar Ali; Li, Changxing; Mallah, Mukhtiar Ali; Noreen, Sobia; Yang, Ling; Saeed, Muhammad Hammad; He, Xiaohai; Ahmed, Bilal; Feng, Feifei; Mirjat, Ali Asghar; Wang, Wei; Jabar, Abdul; Naveed, Muhammad; Li, Jianhua; Zhang, Qiao

doi:10.1016/j.chemosphere.2022.133948

Cited by 293 publications

(101 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Humans ingest PAHs in a variety of ways, such as via inhalation, dermal contact, and ingestion [43]. There are various factors that influence how PAHs affect human health.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus

Wang

2022

IJERPH

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are considered to be endocrine disruptors. In this study, the evidence on the association between PAHs and diabetes was systematically reviewed. PubMed, EMBASE, and ISI Web of Science were systematically searched for studies reporting the association between PAHs and diabetes. Of the 698 articles identified through the search, nine cross-sectional studies were included. Seven were conducted in the general population and two in coke oven workers. Fixed-effects and random-effects models were used to calculate the total effect. Subgroup analysis was further carried out according to the types of PAH metabolites. The results showed that the odds of diabetes were significantly higher for the highest category of urinary naphthalene (NAP), fluorine (FLU), phenanthrene (PHEN), and total mono-hydroxylated (OH-PAH) metabolites compared to the lowest category. The pooled odds ratios (OR) and 95% confidence intervals (CI) were 1.52 (95%CI: 1.19, 1.94), 1.53 (95%CI: 1.36, 1.71), 1.43 (95%CI: 1.28, 1.60), and 1.49 (95%CI: 1.07, 2.08), respectively. In coke oven workers, 4-hydroxyphenanthrene (4-OHPh) was significantly correlated with an increased risk of diabetes. Exposure measurements, outcome definitions, and adjustment for confounders were heterogeneous between studies. The results of the current study demonstrate a potentially adverse effect of PAHs on diabetes. Further mechanistic studies and longitudinal studies are needed to confirm whether PAH metabolite levels are causative, and hence associative, with increased diabetes incidences.

show abstract

“…Humans ingest PAHs in a variety of ways, such as via inhalation, dermal contact, and ingestion [43]. There are various factors that influence how PAHs affect human health.…”

Section: Discussionmentioning

confidence: 99%

“…There are various factors that influence how PAHs affect human health. Some important factors include the duration and route of exposure, the volume or concentration of the PAHs to which one is exposed, and the relative toxicity of the PAHs [43]. The effects of PAHs on human health have been widely studied in recent years.…”

Section: Discussionmentioning

confidence: 99%

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus

Wang

2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…On the other hand, heterocyclic aromatic compounds are monoaromatic or polycyclic aromatic compounds that contain atoms other than carbon, such as nitrogen or sulphur [ 103 ]. Polycyclic aromatic hydrocarbons (PAHs) are a large class of compounds with multiple fused benzene rings that are produced by a variety of natural and anthropogenic activities [ 104 ]. While volcanic eruptions and forest fires are natural sources of PAHs, the primary anthropogenic sources are biomass burning, coal combustion, petroleum volatilization, and vehicle exhaust.…”

Section: Lignin As Aromatic Polymer Derived From Lignocellulosic Biomassmentioning

confidence: 99%

Could termites be hiding a goldmine of obscure yet promising yeasts for energy crisis solutions based on aromatic wastes? A critical state-of-the-art review

Ali

Al-Tohamy

Mohamed

et al. 2022

Biotechnol Biofuels

View full text Add to dashboard Cite

Biodiesel is a renewable fuel that can be produced from a range of organic and renewable feedstock including fresh or vegetable oils, animal fats, and oilseed plants. In recent years, the lignin-based aromatic wastes, such as various aromatic waste polymers from agriculture, or organic dye wastewater from textile industry, have attracted much attention in academia, which can be uniquely selected as a potential renewable feedstock for biodiesel product converted by yeast cell factory technology. This current investigation indicated that the highest percentage of lipid accumulation can be achieved as high as 47.25% by an oleaginous yeast strain, Meyerozyma caribbica SSA1654, isolated from a wood-feeding termite gut system, where its synthetic oil conversion ability can reach up to 0.08 (g/l/h) and the fatty acid composition in yeast cells represents over 95% of total fatty acids that are similar to that of vegetable oils. Clearly, the use of oleaginous yeasts, isolated from wood-feeding termites, for synthesizing lipids from aromatics is a clean, efficient, and competitive path to achieve "a sustainable development" towards biodiesel production. However, the lacking of potent oleaginous yeasts to transform lipids from various aromatics, and an unknown metabolic regulation mechanism presented in the natural oleaginous yeast cells are the fundamental challenge we have to face for a potential cell factory development. Under this scope, this review has proposed a novel concept and approach strategy in utilization of oleaginous yeasts as the cell factory to convert aromatic wastes to lipids as the substrate for biodiesel transformation. Therefore, screening robust oleaginous yeast strain(s) from wood-feeding termite gut system with a set of the desirable specific tolerance characteristics is essential. In addition, to reconstruct a desirable metabolic pathway/network to maximize the lipid transformation and accumulation rate from the aromatic wastes with the applications of various “omics” technologies or a synthetic biology approach, where the work agenda will also include to analyze the genome characteristics, to develop a new base mutation gene editing technology, as well as to clarify the influence of the insertion position of aromatic compounds and other biosynthetic pathways in the industrial chassis genome on the expressional level and genome stability. With these unique designs running with a set of the advanced biotech approaches, a novel metabolic pathway using robust oleaginous yeast developed as a cell factory concept can be potentially constructed, integrated and optimized, suggesting that the hypothesis we proposed in utilizing aromatic wastes as a feedstock towards biodiesel product is technically promising and potentially applicable in the near future.

show abstract

“…Natural sources of PAHs are negligible or less important. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources ( 11 ). In fact, the main source of exposure to PAHs for non-smokers and non-occupationally exposed adults are food.…”

Section: Sources Metabolism and Tissue Toxicity Of Bapmentioning

confidence: 99%

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Benzo(a)pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the vessel-wall cells have been recognized. Many lines of evidence suggest that tobacco smoking and foodborne BaP exposure play a pivotal role in the dysfunctions of vessel-wall cells, such as vascular endothelial cell and vascular smooth muscle cells, which contribute to the formation and worsening of cardiovascular diseases (CVDs). To clarify the underlying molecular mechanism of BaP-evoked CVDs, the present study mainly focused on both cellular and animal reports whose keywords include BaP and atherosclerosis, abdominal aortic aneurysm, hypertension, or myocardial injury. This review demonstrated the aryl hydrocarbon receptor (AhR) and its relative signal transduction pathway exert a dominant role in the oxidative stress, inflammation response, and genetic toxicity of vessel-wall cells. Furthermore, antagonists and synergists of BaP are also discussed to better understand its mechanism of action on toxic pathways.

show abstract

Polycyclic aromatic hydrocarbon and its effects on human health: An overeview

Cited by 293 publications

References 168 publications

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus

The Association between Urinary Polycyclic Aromatic Hydrocarbons Metabolites and Type 2 Diabetes Mellitus

Could termites be hiding a goldmine of obscure yet promising yeasts for energy crisis solutions based on aromatic wastes? A critical state-of-the-art review

Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Contact Info

Product

Resources

About