Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel

Zhao, Wei; Chen, Zonghan; Guan, Meng

doi:10.1002/jcb.29012

Cited by 15 publications

(18 citation statements)

References 36 publications

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“…Titanium dioxide (TiO 2 ) nanoparticles are potential materials in the prevention of osteosarcoma and chondrosarcoma recurrence (4). Paclitaxel, classified as a "plant alkaloid, " is isolated originally from the bark of Taxus brevifolia and has been widely reported in the treatment of osteosarcoma (5,6). TiO 2 -embedded paclitaxel nanoparticles have been tried in the prevention of cancer risk (7).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

et al. 2020

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Objective: Titanium dioxide nanoparticles (TiO 2) nanoparticles have been widely explored in the prevention of cancer risk. Due to the difficult solubility of TiO 2 nanoparticles, it is essential to synthesize new surfactants to increase its bioavailability and anti-tumor activity and reduce its cytotoxicity. Furthermore, oxidative and inflammation are closely associated with the osteosarcoma risk. Chitosan has biocompatibility, antioxidant and anti-inflammatory properties. The effects of chitosan-coated TiO 2-embedded paclitaxel nanoparticles on an osteosarcoma model were explored. Methods: An osteosarcoma model was established and chitosan-coated TiO 2embedded paclitaxel nanoparticles were prepared using a freeze-drying strategy. The morphological characteristics of nanoparticles were observed using scanning electron microscopy (SEM). The physicochemical properties of nanoparticle were evaluated by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The cytotoxicity was tested by using human osteoblast cells hFob1.19 and osteosarcoma cells 143B. Osteosarcoma mice were treated with PBS buffer, paclitaxel, TiO 2embedded paclitaxel and chitosan-coated TiO 2-embedded paclitaxel nanoparticles. The biomarkers of oxidative-inflammatory status, anti-tumor activities and survival rates of the model were measured. Results: XRD analysis showed that the peaks of chitosan/TiO 2 (anatase) were consistent with those of crystalline TiO 2 and broad phase of chitosan. The FTIR spectrum indicated the relevant functional groups in TiO 2. Chitosan-coated TiO 2embedded paclitaxel nanoparticles had good biocompatibility and improve antioxidant and anti-inflammatory properties in the osteosarcoma model. Chitosan-coated TiO 2embedded paclitaxel nanoparticles was less toxic to the cells hFob1.19 and more toxic to the cells 143B than TiO 2-embedded paclitaxel nanoparticles. Chitosan-coated TiO 2embedded paclitaxel nanoparticles showed significant antitumor activity and increased the survival rate of the osteosarcoma model (P < 0.05). Conclusions: Chitosan improved anti-tumor potential of TiO 2-embedded paclitaxel nanoparticles in the prevention of osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

et al. 2020

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“…In addition, through the STAT3 signaling pathway, polydatin activates autophagy and leads to apoptosis in MG-63 human osteosarcoma cells [ 12 ]. Interestingly, it has been reported that polydatin reinforces the sensitivity to chemotherapy with paclitaxel in osteosarcoma cells [ 13 ]. However, whether polydatin can overcome drug resistance against the standard anticancer 5-FU drug, and the fundamental mode of action of this process, have not been elucidated yet.…”

Section: Introductionmentioning

confidence: 99%

Polydatin Counteracts 5-Fluorouracil Resistance by Enhancing Apoptosis via Calcium Influx in Colon Cancer

et al. 2021

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Colon cancer is a disease with a high prevalence rate worldwide, and for its treatment, a 5-fluorouracil (5-FU)-based chemotherapeutic strategy is generally used. However, conventional anticancer agents have some limitations, including the development of drug resistance. Therefore, there has recently been a demand for the improvement of antitumor agents using natural products with low side effects and high efficacy. Polydatin is a natural active compound extracted from an annual plant, and widely known for its anticancer effects in diverse types of cancer. However, it is still not clearly understood how polydatin ameliorates several drawbacks of standard anticancer drugs by reinforcing the chemosensitivity against 5-FU, and neither are the intrinsic mechanisms behind this process. In this study, we examined how polydatin produces anticancer effects in two types of colon cancer, called HCT116 and HT-29 cells. Polydatin has the ability to repress the progression of colon cancer, and causes a modification of distribution in the cell cycle by a flow cytometry analysis. It also induces mitochondrial dysfunctions through oxidative stress and the loss of mitochondrial membrane potential. The present study investigated the apoptosis caused by the disturbance of calcium regulation and the expression levels of related proteins through flow cytometry and immunoblotting analysis. It was revealed that polydatin suppresses the signaling pathways of the mitogen-activated protein kinase (MAPK) and PI3K/AKT. In addition, it was shown that polydatin combined with 5-FU counteracts drug resistance in 5-FU-resistant cells. Therefore, this study suggests that polydatin has the potential to be developed as an innovative medicinal drug for the treatment of colon cancer.

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“…In our precedent paper, we demonstrated that PD was able to induce cell cycle arrest in the S phase, redistributed β-catenin protein, and enhanced osteoblast differentiation markers, including phosphatase alkalin activity, osteopontin, and Notch2 [17]. In addition, polydatin overcomes resistance to paclitaxel in human OS cell lines [34,35]. Published reports suggest that the use of poly (epsiloncaprolactone) complexed with a variety of natural molecules or polymers enhances its biocompatibility and/or its therapeutic action for bone repair.…”

Section: Discussionmentioning

confidence: 82%

Polydatin Incorporated in Polycaprolactone Nanofibers Improves Osteogenic Differentiation

et al. 2022

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Polycaprolactone nanofibers are used as scaffolds in the field of tissue engineering for tissue regeneration or drug delivery. Polycaprolactone (PCL) is a biodegradable hydrophobic polyester used to obtain implantable nanostructures, which are clinically applicable due to their biological safety. Polydatin (PD), a glycosidic precursor of resveratrol, is known for its antioxidant, antitumor, antiosteoporotic, and bone regeneration activities. We aimed to use the osteogenic capacity of polydatin to create a biomimetic innovative and patented scaffold consisting of PCL-PD for bone tissue engineering. Both osteosarcoma cells (Saos-2) and mesenchymal stem cells (MSCs) were used to test the in vitro cytocompatibility of the PD-PCL scaffold. Reverse-phase (RP) HPLC was used to evaluate the timing release of PD from the PCL-PD nanofibers and the MTT assay, scanning electron microscopy, and alkaline phosphatase (ALP) activity were used to evaluate the proliferation, adhesion, and cellular differentiation in both osteosarcoma and human mesenchymal stem cells (MSCs) seeded on PD-PCL nanofibers. The proliferation of osteosarcoma cells (Saos-2) on the PD-PCL scaffold decreased when compared to cells grown on PLC nanofibers, whereas the proliferation of MSCs was comparable in both PCL and PD-PCL nanofibers. Noteworthy, after 14 days, the ALP activity was higher in both Saos-2 cells and MSCs cultivated on PD-PCL than on empty scaffolds. Moreover, the same cells showed a spindle-shaped morphology after 14 days when grown on PD-PCL as shown by SEM. In conclusion, we provide evidence that nanofibers appropriately coated with PD support the adhesion and promote the osteogenic differentiation of both human osteosarcoma cells and MSCs.

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Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel

Cited by 15 publications

References 36 publications

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

RETRACTED: Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma

Polydatin Counteracts 5-Fluorouracil Resistance by Enhancing Apoptosis via Calcium Influx in Colon Cancer

Polydatin Incorporated in Polycaprolactone Nanofibers Improves Osteogenic Differentiation

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