Polyether-ether-ketone/poly(methyl methacrylate)/carbon fiber ternary composites prepared by electrospinning and hot pressing for bone implant applications

Jia, Wenyuan; Cui, Dan; Liu, Yun; Xuan, Jianhua; Sun, Maolei; Cheng, Zhiqiang; Luo, Yungang; Liu, Guomin

doi:10.1016/j.matdes.2021.109893

Cited by 14 publications

(7 citation statements)

References 66 publications

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“…Metallic implants have several disadvantages and require several revision surgeries to avoid the adverse effects of the implants. Inflammation and production of hydrolysis by products [30] Moreover, metallic implants can cause allergic reactions, stress shielding, implant loosening, release of toxic ions, reduced strength and corrosion [23]. To overcome these issues, different natural and synthetic polymer materials are used in implants and drug delivery systems.…”

Section: Polymer Based Implantsmentioning

confidence: 99%

“…New approaches and innovative polymeric implants are being developed for bone repairs and tissue engineering [25]. Polymer materials that are used in bio-medical applications are cellulose [26], collagen [27], deoxyribonucleic acid [28], polyvinyl chloride (PVC) [24], polypropylene (PP) [29] and polymethyl methacrylate (PMMA) [30]. The properties of polymers such as polylactic acid (PLA) can be tailored for biodegradation with controlled degradation [31].…”

Section: Polymer Based Implantsmentioning

confidence: 99%

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Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Zwawi

2022

Eng. Res. Express

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Bio-medical implants have increased demand to treat different medical conditions and complications. Latest research in medical and material science is paving the path for new generation of biomedical implants that mimic the natural bone and tissues for enhanced bio compatibility. Bio-medical implant is required to be bio-compatible, non-toxic and bioactive. Main reasons for implantation are aging, overweight, accidents and genetic diseases such as arthritis or joint pain. Diseases such as osteoporosis and osteoarthritis have ability to severely damage the mechanical properties of bones overtime. Different materials including polymers, ceramics and metals are used for biomedical implants. Metallic implants have high strength, high resistance to corrosion and wear. Biocompatible metallic materials include Ti, Ta, Zr, Mo, Nb, W and Au while materials such as Ni, V, Al and Cr are considered as toxic and hazardous to the body. Bioresorbable and degradable materials dissolve in the body after the healing process. Mg based metallic alloys are highly degradable in the biological environment. Similarly, different polymers such as Poly-lactic acid (PLA) are used as bio-degradable implants and in tissue engineering. Biodegradable stents are used in slow release of drugs to avoid the blood clotting and other complications. Shape memory alloys are employed for bio-implants due to unique set of properties. Different surface physical and chemical modification methods are used to improve the interfacial properties and interaction of implant materials with biological environment. This review explains properties, materials, modifications and short comings for bio-implants.

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Section: Polymer Based Implantsmentioning

confidence: 99%

Section: Polymer Based Implantsmentioning

confidence: 99%

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Zwawi

2022

Eng. Res. Express

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“…Composite fibers combining polycaprolactone with collagen show porosities encouraging osteoblast ingrowth while tailoring implant stability over months as bone regenerates. Gelatin/hydroxyapatite scaffolds support new cartilage formation with calcium/phosphate reinforcement degrading as tissue matures [117][118][119][120][121]. Future directives include optimizing fibre architectures for anatomical congruency and developing intelligent implants incorporating cellular communication for accelerated healing.…”

Section: Implantsmentioning

confidence: 99%

Green Electrospun Nanofibers for Biomedicine and Biotechnology

Berdimurodov,

Dagdag,

Berdimuradov

et al. 2023

Technologies

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Green electrospinning harnesses the potential of renewable biomaterials to craft biodegradable nanofiber structures, expanding their utility across a spectrum of applications. In this comprehensive review, we summarize the production, characterization and application of electrospun cellulose, collagen, gelatin and other biopolymer nanofibers in tissue engineering, drug delivery, biosensing, environmental remediation, agriculture and synthetic biology. These applications span diverse fields, including tissue engineering, drug delivery, biosensing, environmental remediation, agriculture, and synthetic biology. In the realm of tissue engineering, nanofibers emerge as key players, adept at mimicking the intricacies of the extracellular matrix. These fibers serve as scaffolds and vascular grafts, showcasing their potential to regenerate and repair tissues. Moreover, they facilitate controlled drug and gene delivery, ensuring sustained therapeutic levels essential for optimized wound healing and cancer treatment. Biosensing platforms, another prominent arena, leverage nanofibers by immobilizing enzymes and antibodies onto their surfaces. This enables precise glucose monitoring, pathogen detection, and immunodiagnostics. In the environmental sector, these fibers prove invaluable, purifying water through efficient adsorption and filtration, while also serving as potent air filtration agents against pollutants and pathogens. Agricultural applications see the deployment of nanofibers in controlled release fertilizers and pesticides, enhancing crop management, and extending antimicrobial food packaging coatings to prolong shelf life. In the realm of synthetic biology, these fibers play a pivotal role by encapsulating cells and facilitating bacteria-mediated prodrug activation strategies. Across this multifaceted landscape, nanofibers offer tunable topographies and surface functionalities that tightly regulate cellular behavior and molecular interactions. Importantly, their biodegradable nature aligns with sustainability goals, positioning them as promising alternatives to synthetic polymer-based technologies. As research and development continue to refine and expand the capabilities of green electrospun nanofibers, their versatility promises to advance numerous applications in the realms of biomedicine and biotechnology, contributing to a more sustainable and environmentally conscious future.

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“…These 3D printing technologies offer greater advantages for the precise molding and therefore enable the fabrication of patient-specific implants for effective bone repair (figure 4). In addition to 3D printing, it is worth highlighting that other processing methods such as electrospinning can be used to fabricate highly porous PEEK bone implants and these electrospun implants can be integrated with other functional components in order to achieve better functionality [63].…”

Section: D Printingmentioning

confidence: 99%

Modification of polyether ether ketone for the repairing of bone defects

Chen

Cao

et al. 2022

Biomed. Mater.

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Bone damage as a consequence of disease or trauma is a common global occurrence. For bone damage treatment - bone implant materials are necessary across three classifications of surgical intervention (i.e. fixation, repair, and replacement). Many types of bone implant materials have been developed to meet the requirements of bone repair. Among them, polyether ether ketone (PEEK) has been considered as one of the next generation of bone implant materials, owing to its advantages related to good biocompatibility, chemical stability, X-ray permeability, elastic modulus comparable to natural bone, as well as the ease of processing and modification. However, as PEEK is a naturally bioinert material, some modification is needed to improve its integration with adjacent bones after implantation. Therefore, it has become a very hot topic of biomaterials research and various strategies for the modification of PEEK including blending, 3D printing, coating, chemical modification and the introduction of bioactive and/or antibacterial substances have been proposed. In this systematic review, the recent advances in modification of PEEK and its application prospect as bone implants are summarized, and the remaining challenges are also discussed.

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Polyether-ether-ketone/poly(methyl methacrylate)/carbon fiber ternary composites prepared by electrospinning and hot pressing for bone implant applications

Cited by 14 publications

References 66 publications

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Green Electrospun Nanofibers for Biomedicine and Biotechnology

Modification of polyether ether ketone for the repairing of bone defects

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