Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

Abstract

Abstract:Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly (acrylic acid)-poly (N-isopropylacrylamide) (PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly (acrylic acid) (HPC-PAA) complexes as the templates. The capsules showed a high drug loading (∼280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and pH of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.

Utilizing Edible Agar as a Carrier for Dual Functional Doxorubicin-Fe3O4 Nanotherapy Drugs

“…In addition to improving drug delivery to tumor cells and prolonging drug efficacy, the use of combined chemotherapy has also been widely studied in order to increase the functionality of particle carriers [ 3 ]. Based on published research, drug delivery systems require three key features: high drug-loading efficiency [ 4 , 5 ], controlled drug release [ 6 , 7 ], and the safe decomposition of drug carriers [ 8 ]. Therefore, carrier materials from organic natural materials or inorganic synthetic products have been widely developed in recent years, such as 1D coordination polymer or carbon nanotubes [ 9 , 10 ], kaolinite nanoclay carrier with 2D structure [ 11 ], mesoporous organosilica with 3D structure [ 12 , 13 , 14 ], exosome [ 15 ], natural liposomes or natural polymer agar, biomacromolecular scaffolds [ 16 ], and magnetic composite, etc.…”

Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

“…Moreover, NIPAm nanogels with such a core-shell morphology would illustrate dual responsive properties with respect to both temperature and pH. Separate studies have, so far, investigated the effect of either temperature on NIPAm gels [ 21 , 37 ], or pH [ 38 , 39 ], or both temperature and pH on core-shell gels [ 40 , 41 , 42 ]. A number of researchers have focused on the synthesis of NIPAm gels with increased VPTT (37–42 °C) for hyperthermal drug release [ 40 , 43 , 44 ] or synthesis of NIPAm gels with a focus on increasing the drug loading capacity.…”