Polymeric<i>vs</i>hydroxyapatite-based scaffolds on dental pulp stem cell proliferation and differentiation

Khojasteh, Arash; Motamedian, Saeed Reza; Rad, Maryam Rezai; Shahriari, Mehrnoosh Hasan; Nadjmi, Nasser

doi:10.4252/wjsc.v7.i10.1215

Cited by 37 publications

(25 citation statements)

References 30 publications

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“…The hMSCs seeded on nanocomposite PCL/HA scaffolds in 12-well plate and showed high proliferation in HA concentration-dependent manner as compared to Neat-PCL (Figure 4). Additionally, previous studies have demonstrated that PCL/HA-based scaffolds showed high proliferation and osteogenic differentiation in human dental pulp stem cells (hDPSCs) and mouse adipose-derived stem cells (ADSCs) (33, 34). Interestingly, magnetic bioinspired hybrid nanocomposite collagen-hydroxyapatite scaffolds enhanced cellular proliferation and restored bone generation (35, 36).…”

Section: Resultsmentioning

confidence: 99%

Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration

Mishra¹

2017

Front Biosci

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In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and assessed its biocompatibility. PCL/HA composite is superior as a scaffold compared to PCL alone. Furthermore, increasing HA content (5–10%) was more efficacious in supporting cell-scaffold attachment, expression of ECM molecules and proliferation. These results suggest that PCL/HA is useful as a scaffold for tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration

Mishra¹

2017

Front Biosci

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“…They reported that PLLA scaffolds supported adhesion, proliferation, and osteogenic differentiation of hDPSCS compared to other scaffolds. For the current study the expression patterns of both markers at 14 and 21 days showed that 14-day cultivation periods is adequate for hSHEDs with/without PLA scaffolds to differentiate into osteoblasts (30). …”

Section: Discussionmentioning

confidence: 99%

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

İslam

Mammadov

Kendirci

et al. 2017

Iran Red Crescent Med J

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“…In order to achieve successful regeneration, the scaffolds, cells, and bioactive signaling molecules are required to induce stem cell differentiation into the dental tissue type (11). An ideal scaffold should be able to interact with cells, offer a platform for cell adhesion and proliferation, and enhance the regeneration of tissue (12). Early studies on dental pulp tissue engineering with tooth slices or segments have used polylactic or polyglycolic acid (PLGA) as scaffold materials.…”

Section: Types Of Scaffolding For Tissue Engineering In Dental Pulp Rmentioning

confidence: 99%

Naturally derived scaffolds for dental pulp regeneration: a review

Osman¹,

Ahmad²,

Noordin³

2019

Gulhane Med J

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Dental pulp regeneration via stem cell engineering approach offers a great potential in tackling the difficulty in dental clinical situations such as teeth loss and periodontal diseases. One of the potential approaches in dental tissue engineering includes the application of dental stem cells-based therapy. In this approach, dental stem cells are generally cultured on special biodegradable membrane filters or scaffolds, allowing for three-dimensional (3D) pulp tissues formation before it can be inserted into the area of damaged dental pulp for dentin regeneration. The naturally derived scaffold, onto which stem cells are let to grow include platelet rich fibrin (PRF), collagen, hyaluronic acid (HA), polysaccharides, silk and amniotic membrane (AM). Biological scaffolds offer special characteristics such as biocompatibility, biodegradability, low immunogenicity and ability to support cells growth for various applications of tissue engineering. This review discusses the available naturally derived scaffolds for dental pulp regeneration and highlights their potential advantages. We also aim to improve the understanding of the application of natural scaffolds in dental pulp regeneration.

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Polymericvshydroxyapatite-based scaffolds on dental pulp stem cell proliferation and differentiation

Abstract: PLLA scaffold supports adhesion, proliferation and osteogenic differentiation of hDPSCs. Hence, it may be useful in combination with hDPSCs for cell-based reconstructive therapy.

Cited by 37 publications

References 30 publications

Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration

Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

Naturally derived scaffolds for dental pulp regeneration: a review

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