Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres

Manogna, Katta; Reddy, E. Nanda Krishna; Shilpa, T.

doi:10.5958/2321-5844.2017.00008.5

Res. Jour. Topi. and Cosmet. Scie.

2017

DOI: 10.5958/2321-5844.2017.00008.5

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Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres

Katta Manogna¹,

E. Nanda Krishna Reddy²,

T. Shilpa³

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Cited by 4 publications

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Formulation Design and Evaluation of Ornidazole Microsphere in a Bioadhesive gel for Local Therapy of Vaginal Candidiasis

Abraham

Vijayan²,

Koshy

et al. 2022

RJPT

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The aim of present work is to design a novel vaginal drug delivery system composed of Ornidazole microspheres incorporated in a bioadhesive gel. Microspheres were prepared by solvent evaporation method by using Eudragit RS 100 and Eudragit RL 100 polymers with different drug/ polymer ratios. The microspheres were found to be discrete, spherical with free flowing properties and evaluated for particle size analysis, shape (SEM), drug entrapment efficiency, percentage drug loading, and in vivo drug release studies. The selected microsphere formulation (F7 and F8, containing drug polymer ratios 1:1:1 and 1:0.25:1.75 respectively) was incorporated in a bioadhesive carbopol 934P gel. The formulation (F8.ODZ-MG) which showed maximum of 91.03% release at 8h was then subjected to stability studies and antifungal activity. The antifungal activity of the F8.ODZ-MG and placebo gel was evaluated against Candida albicans 1012 by using cup plate method. This showed that ODZ-MG was capable to control the growth of Candida albicans for more than 14h. Placebo gel did not show any zone of inhibition. Stability studies were done as per ICH guidelines for a period of 6 months. Initial and third month studies were done and evaluated for parameters such as pH, drug content, drug content uniformity, extrudability, spreadability, viscosity and in vitro drug release. The results showed that there were no significant changes in the drug content and in vitro drug release. It may be concluded from the present study that ODZ-MG can be used as a novel delivery system for local therapy of vaginal candidiasis.

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Formulation Design and Evaluation of Ornidazole Microsphere in a Bioadhesive gel for Local Therapy of Vaginal Candidiasis

Abraham

Vijayan²,

Koshy

et al. 2022

RJPT

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A Promising Oral Drug Delivery System of Microsponges: A Brief Review

Pashikanti

Ashok

2022

RJPT

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In the modern era of drug delivery, microsponges have their own tremendous properties of porous nature, due to this porous nature they have a capacity to entrap active drug and acts as a drug carrier because of this entrapment controlling the drug release and targeting the drug to a particular site is possible. Initially, this microsponge drug delivery has been used for topical route and later on oral route, recently, researches focused on the pulmonary and parenteral route of delivery. The present review aims at the development of microsponge technology in oral drug delivery, preparation, formulation considerations, characterization, recent advancements, and future prospects of microsponge drug delivery.

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A Review on Microspheres as Controlled Release Drug Delivery

Paul,

Keerthy,

Sharma

et al. 2023

AJPR

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Microspheres play a totally critical function as a particulate drug transport machine due to theirtiny size and different properties. Microspheres proved an appropriate bridge to scale the gap over to formulate a powerful dosage form, to managed drug release, to simulate controlled drug release. Microspheres are often free-flowing stable powders, which include proteins or artificial polymers, which can be biodegradable. Microspheres having a particle size in the range of 0.1-800µm, can be delivered by several routes like oral, parenteral, nasal, ophthalmic, transdermal, colonal, etc. Various recent advancements in the case of microspheres like mucoadhesive, hollow, floating, micro balloons, and magnetic have contributed to overcoming the diverse troubles which might be related to using microspheres, which incorporates site-precise focused on and stepped forward release. In the future by combining various new designing, planning’s, and strategies, microspheres will find a central place in novel drug delivery, especially in diseased molecular sorting, genetic materials, safe, targeting, and powerful drug delivery.

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Polymeric Novel Vesicular Drug Delivery System: An Updated Overview of Microspheres

Cited by 4 publications

References 0 publications

Formulation Design and Evaluation of Ornidazole Microsphere in a Bioadhesive gel for Local Therapy of Vaginal Candidiasis

Formulation Design and Evaluation of Ornidazole Microsphere in a Bioadhesive gel for Local Therapy of Vaginal Candidiasis

A Promising Oral Drug Delivery System of Microsponges: A Brief Review

A Review on Microspheres as Controlled Release Drug Delivery

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