Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Therefore many techniques are being explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most important method for enhance the solubility (dissolution rate) and hence oral bioavailability of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline pure drug is converted into amorphous form and hence the solubility is increased. Polymer incorporating in solid dispersion technology is usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. This review mainly discus about solid dispersion, preparation methods, and finally characterization.

Background Prucalopride drug estimation was reported previously by UV spectroscopy methods and few HPLC methods with retention time 4.73 min as per literature survey. Aim of study A new analytical RP- HPLC method development and validation for bulk and pharmaceutical dosage forms of Prucalopride drug with less retention time than reported methods.Methodology The separation was carried out by using RP-HPLC with the mixture of 0.1 orthophosphoric acid methanol in ratio of 3070 vv as mobile phase. The mobile phase at a flow rate of 1 mLmin was pumped and UV detection was found at 225 nm.Results The selected chromatographic conditions gave retention time at 1.5 min for Prucalopride. Conclusion This developed method was validated for precision accuracy linearity robustness as per International Conference of Harmonization ICH guidelines.

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Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules increase the residence time of the dosage form at the site of absorption. Bioadhesion may be defined as the state in which two materials, at least one of which is of a biological nature, are held together for extend periods of time by interfacial forces Mucosal layer represents potential sites for the attachment of any bioadhesive systems because mucosal layer lines number of the body including the gastro intestinal tract, the urogenital tract, vaginal tract, the eye, ear, and nose. The mucoadhesive Bilayer tablets consisting of two various types of drug molecules and they show on set of actions at their particular sites. This review describes the structure of mucosal layer, mechanism of action of mucoadhesion, and preparation techniques of Bilayer tablets and evaluation parameters of tablets.