Polymorphism of FUT1 Gene M307 and its Relationship with Partial 
 Immune Indexes and Economic Traits in Yorkshire Pigs

Zhu, Shanfeng; Liu, Ying; Dong, Wende; Zheng, Xianrui; Zhu, Guoqiang; Wu, Shenglong; Bao, Wenbin

doi:10.3923/ajava.2014.253.261

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…Also, the positive effect of the FUT1 AA genotype was observed in studies on Yorkshire pigs (Zhu et al, 2014). The age of reaching 100 kg of AA genotype pigs was shorter by 4.23 days (P < 0.05) than that of animals with AG genotype, whereas backfat thickness and depth of longissimus dorsi were similar.…”

Section: Discussionmentioning

confidence: 72%

Association of Fut1 and Slc11a1 gene polymorphisms with productivity traits of Large White pigs

Sukhno

Vashchenko

Saenko

et al. 2022

Regul. Mech. Biosyst.

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The purpose of our work was to study the polymorphism of genes associated with disease resistance and to search for their associations with productive traits in the population of the Ukrainian Large White pigs. For this study, 50 pigs were used, observations and measurements were carried out at the age from birth to 180 days. Genetic studies were carried out in a certified laboratory of the Institute of Pig Breeding and Agroindustrial Production. In the study of fucosyltransferase 1 and solute carrier family 11 member 1 genes, polymorphism was found in three of the five analyzed loci. In the Ukrainian Large White subpopulation of pigs the informativeness of these gene polymorphisms was at the optimal level for associative analysis, Polymorphism Information Content was greater than 0.3 in two loci. A sufficiently high level of Polymorphism Information Content indicates the value of this breed to preserve the biodiversity of pigs. The distribution of genotypes at some loci of the solute carrier family 11 member 1 gene was characterized by a deviation from the theoretically expected one due to the increase in the frequency of the heterozygous genotype. There was also a statistically confirmed deviation of the genotypes’ distribution from the normal and polymorphism fucosyltransferase 1 gene, but in this case in the direction of increasing the frequency of both homozygous variants. These results indicate the presence of a certain selection pressure on the mentioned polymorphisms and their possible impact on productive traits. The influence of solute carrier family 11 member 1 gene polymorphism on the weight of pigs at the age of 120 and 180 days, the average daily gain recorded in the period 28–120 days and from birth to 180 days, as well as on the backfat thickness, was established. The preferred genotype is TT, which can be used in breeding to obtain more productive animals with increased disease resistance, but in the selection of animals at this locus, it is necessary to control the backfat thickness and prevent breeding of pigs that may worsen this trait.

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Section: Discussionmentioning

confidence: 72%

Association of Fut1 and Slc11a1 gene polymorphisms with productivity traits of Large White pigs

Sukhno

Vashchenko

Saenko

et al. 2022

Regul. Mech. Biosyst.

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“…Riis Poulsen et al (2018) found that FUT1 genotype did not affect the growth performance of piglets until 34 d old. The age at 100 kg of AA genotype pigs was shorter than that of AG, whereas BFT and DLD were similar in Zhu et al (2014). Bao et al (2011) indicated that ADG of animals with AA was higher than those of AG and GG types.…”

Section: Genotypic and Allelic Distribution Of Fut1 Genementioning

confidence: 91%

“…Therefore, marker-assisted selection might help to control the disease in the targeted population by using preferably animals with genotype AA (Wang et al 2012). The effect of FUT1 genotypes on vital economic traits has been reported (Jiang et al 2005;Bao et al 2011;Zhu et al 2014;Geraci et al 2019), but varying results on the relationship between these genotypes and reproduction and production performances still remain. The gilts with AA genotype grow faster than the AG and GG ones, whereas sows with AA genotype have more piglets born alive than those with AG and GG genotypes (Zhu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The effect of FUT1 genotypes on vital economic traits has been reported (Jiang et al 2005;Bao et al 2011;Zhu et al 2014;Geraci et al 2019), but varying results on the relationship between these genotypes and reproduction and production performances still remain. The gilts with AA genotype grow faster than the AG and GG ones, whereas sows with AA genotype have more piglets born alive than those with AG and GG genotypes (Zhu et al 2014). In contrast, no effect of FUT1 gene on growth performance traits of Duroc and Landrace boars was detected in Huang et al (2008).…”

Section: Introductionmentioning

confidence: 99%

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Mutation c.307G>A inFUT1gene has no effect on production performance of Yorkshire pigs in the tropics: the case of Vietnam

Duc

Thinh

et al. 2020

Can. J. Anim. Sci.

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The alpha (1) fucosyltransferase gene (FUT1) is a candidate gene for controlling the adhesion of Escherichia coli F18 receptor. Indeed, a single-nucleotide polymorphism, c.307G>A, located in the gene is such that pigs with AA genotype are resistant to entero-toxigenic E. coli F18, whereas those with AG and GG genotypes are sensitive. An experiment was carried out in northern Vietnam from March 2016 to May 2017 to determine FUT1 genotype frequencies and the effect of these genotypes on production performance of Yorkshire pigs. A total of 613 animals were genotyped using polymerase chain reaction – restriction fragment length polymorphism method. The body weights at birth, weaning, initial fattening period, and final fattening period were collected from 611, 516, 479, and 418 animals, respectively, whereas backfat thickness, depth of longissimus dorsi, and lean meat percentage were recorded from 328 animals. The frequencies of FUT1 genotypes were found to be in Hardy–Weinberg equilibrium (P = 0.51). Effect of FUT1 genotype was not observed for all production traits (P > 0.05), whereas final body weight and depth of longissimus dorsi were significantly different between females and males (P < 0.05). These results suggest that selection of Yorkshire pigs resistant to entero-toxigenic E. coli F18 could be effective without adversely affecting average daily gain and lean meat.

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“…Ассоциация этого ДНК-маркера с воспроизводительными признаками подтверждена многочисленными исследованиями как за рубежом (8)(9)(10), так и в нашей стране (11)(12)(13). Косвенное влияние на воспроизводительные качества свиней могут оказывать ДНК-маркеры ECR F18/FUT1 (рецептор Escherichia coli F18/FUT1), генетические варианты которого связывают с устойчивостью к послеотъемной диарее (14,15), и MUC4 (муцин 4) (16), генетические варианты которого ассоциированы с устойчивостью к колибактериозу (17,18). Кроме того, современные программы генетического совершенствования свиней наряду с улучшением воспроизводительных качеств ориентированы на повышение показателей мясной и откормочной продуктивности.…”

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The Study of Effect of Genotypes for Dna Marker on Reproductive Qualities of Sows of Large White and Landrace Breeds

Мельникова¹,

Bardukov²,

Fornara³

et al. 2019

s-h. biol.

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Скорость генетического прогресса по низконаследуемым признакам воспроизводства у свиней может быть увеличена за счет интеграции в селекционные программы ДНК-маркеров, ассоциированных с локусами количественных признаков (QTL) репродуктивных качеств (маркерная селекция, marker-assisted selection, MAS). В представленной работе впервые получены результаты, указывающие на отсутствие значимого влияния гена IGF2 на фертильность свиноматок. Сопряженность генов ECR F18/FUT1, ESR и MUC4 с оценками племенной ценности по собственной продуктивности свиноматок оказалась значимой и подтверждала взаимосвязь генетических и физиологических механизмов формирования репродуктивных особенностей свиней. Целью настоящих исследований была оценка влияния ДНК-маркеров IGF2 (инсулиноподобный фактор роста 2), ECR F18/FUT1 (рецептор Escherichia coli F18), ESR (эстрогеновый рецептор) и MUC4 (муцин 4) на признаки фертильности свиноматок пород крупная белая и ландрас. Материалом служили данные первичного учета показателей воспроизводительных качеств по результатам первых трех опоросов свиноматок (Sus scrofa) пород крупная белая (n = 894) и ландрас (n = 513) в ООО «Селекционно-гибридный центр» (Воронежская обл.). Были проанализированы абсолютные значения и скорректированные фенотипические показатели, а также проведена оценка племенной ценности особей (Estimated Breeding Value, EBV) по следующим признакам: число рожденных поросят в гнезде за один опорос (TNB), число живорожденных поросят за один опорос (NBA), средняя масса поросенка в гнезде при рождении (BW), скорректированная масса поросенка в гнезде при рождении (BW adj), молочность свиноматки (масса гнезда при отъеме на 21-е сут) (WW), скорректированная молочность свиноматки (скорректированная масса гнезда при отъеме на 21-е сут) (WW adj). Геномную ДНК выделяли из проб ткани (ушной выщип) с использованием набора реагентов ДНК-Экстран-2 (ООО «НПФ Синтол», Россия). Были определены частоты встречаемости генотипов по анализируемым маркерам и выявлены их достоверные отклонения от состояния популяционного равновесия для животных крупной белой породы по гену IGF2 (p < 0,01) и породы ландрас по генам IGF2 (p < 0,01), ECR F18/FUT1 (p < 0,01) и MUC4 (p < 0,001). Значение коэффициента гомозиготности по Робертсону (Ca) было наибольшим для генотипов по генам IGF2 и ECR F18/FUT1, при этом для особей крупной белой породы показатель достигал соответственно 0,76 и 0,65 против 0,60 и 0,72 для породы ландрас. Коэффициенты наследуемости анализируемых признаков для двух пород варьировали в следующих пределах: TNB

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Polymorphism of FUT1 Gene M307 and its Relationship with Partial Immune Indexes and Economic Traits in Yorkshire Pigs

Cited by 5 publications

References 7 publications

Association of Fut1 and Slc11a1 gene polymorphisms with productivity traits of Large White pigs

Association of Fut1 and Slc11a1 gene polymorphisms with productivity traits of Large White pigs

Mutation c.307G>A inFUT1gene has no effect on production performance of Yorkshire pigs in the tropics: the case of Vietnam

The Study of Effect of Genotypes for Dna Marker on Reproductive Qualities of Sows of Large White and Landrace Breeds

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