Polymorphism of TPH2 gene rs120074175 is not associated with risk factors of schizophrenia

Laksono, James P; Sumirtanurdin, Riyadi; Dania, Haafizah; Ramadhani, Fitri N; Perwitasari, Dyah Aryani; Abdulah, Rizky; Barliana, Melisa Intan

doi:10.4103/jpbs.jpbs_216_19

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…The research about treatment are still evolving to develop interventions that resulting in efficacy of the treatment (Ganguly et al, 2018) (Rubio & Kane, 2022). The forth clusters described the genetic and mechanism of schizophrenia as shown by keyword -brain‖, and -polymorphism‖ as schizophrenia is strongly correlated with genetic predisposition (Laksono et al, 2019) (Maritska et al, 2022). There are also increasing interest in other mental disorder such as bipolar disorder and depression (Vogelzang et al, 2012);Xu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

A Bibliometric Analysis of The Schizophrenia Publications of South East Asia in 2002-2023

Nudhar,

Syakurah,

Idris

et al. 2023

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Aims: We intend to do examine the productivity in literature related to schizophrenia in South East Asia trends in over 2 decades using bibliometric analysis. Method: We performed a systematic search through Web of Science Core Collection (WoSCC) database to searched articles related to schizophrenia between 1 January 2002 and 1 June 2023 and refined by Countries/Regions of 11 South East Asia countries. After filtering irrelevant publications, the VOSviewer later processed the informations and give visualizations of publications maps such as keywords, country, institutions, country, etc. Results: Of the total 876 literatures from Web of Science Core Database identified, 301 articles included in further analysis. There were increasing number of article related to schizophrenia published from 2002 to 2023. The analysis of selected keywords grouped them into six clusters according to similar topic. Analysis based on country revealed that Singapore published the most number of publications (41%) followed by Malaysia (29%) of total 301 articles. Analysis of authors showed that most of the top 10 authors were from Singapore with the highest paper was conducted by Chong SA with 50 total publications (16.6%). Conclusion: The research on schizophrenia mainly related to pharmacological treatment, psychosocial impact, comorbidities and pathophysiology. The research related to mental health policy and community based services stil need further explorations Keywords: Bibliometric, Schizophrenia, Publications

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Section: Discussionmentioning

confidence: 99%

A Bibliometric Analysis of The Schizophrenia Publications of South East Asia in 2002-2023

Nudhar,

Syakurah,

Idris

et al. 2023

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The polymorphism of TNFα (rs1799964) gene and schizophrenia risk: A meta-analysis

et al. 2020

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Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis

et al. 2022

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Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic stress on developmental trajectories. Such experiences can become biologically consolidated, creating individual vulnerability to psychological and psychiatric issues later in life. The hippocampus, amygdala, and the medial prefrontal cortex are all important limbic structures involved in the processes that undermine mental health. Hyperarousal of the sympathetic nervous system with sustained allostatic load along the Hypothalamic Pituitary Adrenal (HPA) axis and its connections has been theorized as the basis for adult psychopathology following early childhood trauma. In this review we synthesize current understandings and hypotheses concerning the neurobiological link between childhood trauma, the HPA axis, and adult psychiatric illness. We examine the mechanisms at play in the brain of the developing child and discuss how adverse environmental stimuli may become biologically incorporated into the structure and function of the adult brain via a discussion of the neurosequential model of development, sensitive periods and plasticity. The HPA connections and brain areas implicated in ELS and psychopathology are also explored. In a targeted review of HPA activation in mood and psychotic disorders, cortisol is generally elevated across mood and psychotic disorders. However, in bipolar disorder and psychosis patients with previous early life stress, blunted cortisol responses are found to awakening, psychological stressors and physiological manipulation compared to patients without previous early life stress. These attenuated responses occur in bipolar and psychosis patients on a background of increased cortisol turnover. Although cortisol measures are generally raised in depression, the evidence for a different HPA activation profile in those with early life stress is inconclusive. Further research is needed to explore the stress responses commonalities between bipolar disorder and psychosis in those patients with early life stress.

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Polymorphism of TPH2 gene rs120074175 is not associated with risk factors of schizophrenia

Cited by 3 publications

References 18 publications

A Bibliometric Analysis of The Schizophrenia Publications of South East Asia in 2002-2023

A Bibliometric Analysis of The Schizophrenia Publications of South East Asia in 2002-2023

The polymorphism of TNFα (rs1799964) gene and schizophrenia risk: A meta-analysis

Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis

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