Polymorphisms of drug‐metabolizing genes and risk of non‐Hodgkin lymphoma

Abstract

Drug metabolizing genes are involved in the detoxification of chemical carcinogens. Polymorphisms in drug-metabolizing genes affect the risk of some forms of cancer. We analyzed six polymorphisms to evaluate their association with risk for non-Hodgkin lymphoma (NHL), and to examine whether smoking modifies these associations in population-based study in Korea (713 cases and 1,700 controls). The GSTP1 rs1695 AG and the combined AG/GG genotypes were associated with decreased risk of NHL (odds ratio (OR) AG 5 0.67, 95% confidence interval (CI) 5 0.55-0.82; OR AG/GG 5 0.66, 95% CI 5 0.54-0.80) and DLBCL (OR AG 5 0.63, 95% CI 5 0.49-0.82; OR AG/GG 5 0.64, 95% CI 5 0.50-0.82). For T-cell lymphoma, only the combined AG/GG genotype was associated with decreased risk (OR AG/GG 5 0.65, 95% CI 5 0.44-0.96). The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associated with increased risk of NHL (OR AG 5 1.28, 95% CI 5 1.07-1.54; OR AG/GG 5 1.26, 95% CI 5 1.06-1.51) and DLBCL (OR AG 5 1.32, 95% CI 5 1.04-1.66; OR AG/GG 5 1.30, 95% CI 5 1.03-1.63), but not T-cell lymphoma. Smoking does not modify the association between these polymorphisms and NHL risk. Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk of NHL in Korea. Am. J. Hematol. 84:821-825, 2009. V

Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine

“…Future investigations should validate this result and clarify the underlying mechanisms. A lot of researches are interested in CYP1A1 rs1048943 A[G, and this SNP has been reported to be associated with the risk of lung cancer (Chen et al 2011), breast cancer (Sergentanis and Economopoulos 2010), non-Hodgkin lymphoma (Kim et al 2009), esophageal cancer (Zhuo et al 2009), chronic myeloid leukemia (Taspinar et al 2008), colorectal cancer (Kiss et al 2007), gallbladder cancer (Tsuchiya et al 2007), prostate cancer (Yang et al 2006;Murata et al 2001), and epithelial ovarian cancer (Aktas et al 2002).…”

The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer

“…The wild-type genotype GSTP1 *A has been correlated with the development and progression of Hodgkin's and non-Hodgkin’s lymphoma [99–101]. Moreover, the GSTP1 Val105 polymorphism is generally associated with higher susceptibility to a variety of malignancies (see Table 2).…”

Cigarette smoking and risk of lymphoma in adults

“…1), a total of 603 abstracts were identified and screened. Among 50 articles, 26 reported solely on NHL (Tuyp et al, 1987;Linet et al, 1992;Persson et al, 1993;Tokudome et al, 1993;Hardell et al, 1994;Schnatter et al, 1996;Zahm et al, 1997;De Stefani et al, 1998;Freedman et al, 1998;Zhang et al, 1999;Parker et al, 2000;Fabbro-Peray et al, 2001;Morales Suarez-Varela et al, 2001;Kim et al, 2002;Besson et al, 2003Besson et al, , 2006bFritschi et al, 2004;Morton et al, 2005;Schollkopf et al, 2005;Talamini et al, 2005;'t Mannetje et al, 2008;Kim et al, 2009;Liu et al, 2009;McDuffie et al, 2009;Bertrand et al, 2010;Troy et al, 2010), 13 solely on HL (Newell et al, 1973;Matthews et al, 1984;Bernard et al, 1987;Stagnaro et al, 2001;Briggs et al, 2002;Chang et al, 2004;Gallus Cigarette smoking and risk of lymphoma Sergentanis et al 133 et al, 2004;Glaser et al, 2004;Besson et al, 2006a;Hjalgrim et al, 2007;Willett et al, 2007;…”