Polysaccharide from spore of Ganoderma lucidum ameliorates paclitaxel-induced intestinal barrier injury: Apoptosis inhibition by reversing microtubule polymerization

Li, Dan; Gao, Liang; Li, Muxia; Luo, Yingyi; Xie, Yizhen; Luo, Ting; Su, Lu; Yong, Tianqiao; Chen, Shaodan; Jiao, Chunwei; Su, Juanjuan; Huang, Song

doi:10.1016/j.biopha.2020.110539

Cited by 41 publications

(25 citation statements)

References 54 publications

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“…Importantly, SBSGL could obviously reduce cisplatin-induced intestine damage, suggesting that SBSGL has a protective effect against cisplatin-induced intestinal toxicity. This result was consistent with an earlier report that polysaccharide extracted from spores of Ganoderma lucidum could ameliorate paclitaxel-induced intestinal injury ( Li et al, 2020 ). For bone marrow suppression, cisplatin-induced myelosuppression often presents as anemia, leukopenia, and thrombocytopenia in clinics ( Oun et al, 2018 ).…”

Section: Discussionsupporting

confidence: 93%

“…Among them, triterpenoids and polysaccharides are currently the most widely studied and considered as the main active ingredients of sporoderm-broken spores of Ganoderma lucidum (SBSGL) ( Lin and Yang, 2019 ). There is strong evidence demonstrating that SBSGL has a broad spectrum of bioactivities such as the antitumor effect in osteosarcoma, cholangiocarcinoma, and colorectal tumors ( Li et al, 2016 ; Li et al, 2017 ; Zhang et al, 2019 ); immunomodulation ( He et al, 2020 ); and protective effect on radiotherapy- or chemotherapy-induced toxicity ( Dai et al, 2019 ; Li et al, 2020 ). However, whether SBSGL could enhance the antitumor effect of cisplatin in ovarian cancer and ameliorate cisplatin-induced side effects still waits to be verified.…”

Section: Introductionmentioning

confidence: 99%

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Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Cen

Chen

et al. 2022

Front. Pharmacol.

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Although platinum-based chemotherapeutics such as cisplatin are the cornerstone of treatment for ovarian cancer, their clinical application is profoundly limited due to chemoresistance and severe adverse effects. Sporoderm-broken spores of Ganoderma lucidum (SBSGL) have been reported to possess antitumor effects. However, the function and mechanism of SBSGL and its essential composition, ganoderic acid D (GAD), in the cisplatin therapy on ovarian cancer have yet to be investigated. Here, we investigated the combined effect of SBSGL and cisplatin in an ovarian tumor xenograft model. The results showed that combining SBSGL with cisplatin reduced tumor growth and ameliorated cisplatin-induced intestinal injury and myelosuppression. We also confirmed that GAD could enhance the therapeutic effect of cisplatin in SKOV3 and cisplatin-resistant SKOV3/DDP cells by increasing the intracellular reactive oxygen species (ROS). Mechanistically, we proved that ROS-mediated ERK signaling inhibition played an important role in the chemo-sensitization effect of GAD on cisplatin in ovarian cancer. Taken together, combining SBSGL with cisplatin provides a novel therapeutic strategy against ovarian cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Cen

Chen

et al. 2022

Front. Pharmacol.

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“…The polysaccharide fractions (SP-3-2) showed higher anti-tumor activity against the HepG2 cells than a blank control at 1 mg/ml concentration ( 49 ). After HWE (15 L/kg) for 2 h, followed by ethanol purification, polysaccharides from sporoderm-broken spore of G. lucidum (SGP) could improve the chemotherapy side effects by relieving a small intestinal barrier injury caused by paclitaxel (PTX) ( 50 ).…”

Section: Extraction Isolation and Purification Of Polysaccharidesmentioning

confidence: 99%

Polysaccharides as Potential Anti-tumor Biomacromolecules —A Review

et al. 2022

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Cancer, as one of the most life-threatening diseases, has attracted the attention of researchers to develop drugs with minimal side effects. The bioactive macromolecules, such as the polysaccharides, are considered the potential candidates against cancer due to their anti-tumor activities and non-toxic characteristics. The present review provides an overview on polysaccharides' extraction, isolation, purification, mechanisms for their anti-tumor activities, structure-activity relationships, absorption and metabolism of polysaccharides, and the applications of polysaccharides in anti-tumor therapy. Numerous research showed extraction methods of polysaccharides had a significant influence on their activities. Additionally, the anti-tumor activities of the polysaccharides are closely related to their structure, while molecular modification and high bioavailability may enhance the anti-tumor activity. Moreover, most of the polysaccharides exerted an anti-tumor activity mainly through the cell cycle arrest, anti-angiogenesis, apoptosis, and immunomodulation mechanisms. Also, recommendations were made to utilize the polysaccharides against cancer.

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“…Collectively, SGP restored gut microbiota dysbiosis and thus alleviated adverse effects of chemotherapy, suggesting its potential implication as a supplement for the treatment of breast cancer. Another study revealed that SGP relieved PTX-caused body weight lost and ameliorated PTX-induced intestinal barrier injury in breast cancer-bearing mice ( Li D. et al, 2020 ). The combined administration of SGP and PTX could improve intestinal barrier function by suppressing endotoxemia and upregulating tight junction proteins, such as E-cadherin, β-catenin, occludin and ZO-1.…”

Section: The Antitumor Activities Of Polysaccharides From G...mentioning

confidence: 99%

Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma

Wang

2022

Front. Pharmacol.

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Cancer ranks as a primary reason for death worldwide. Conventional anticancer therapies can cause severe side effects, and thus natural products may be promising drug candidates for cancer therapy. Accumulating evidence has verified the prominent anticancer properties of Ganoderma polysaccharides, suggesting that Ganoderma polysaccharides may be effective chemopreventive agents of natural origin. Based on their abilities to prevent cancer development by regulating the DNA damage response, cancer cell proliferation, apoptosis, host immunity, gut microbiota and therapeutic sensitivity, there has been increasing interest in elucidating the clinical implication of Ganoderma polysaccharides in cancer therapy. In this review, we summarize recent findings pertaining to the roles of bioactive polysaccharides from Ganoderma in cancer pathogenesis, discuss the multifarious mechanisms involved and propose future directions for research. A more sophisticated understanding of the anticancer benefits of Ganoderma polysaccharides will be helpful for improving current treatments and developing novel therapeutic interventions for human malignancies.

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Polysaccharide from spore of Ganoderma lucidum ameliorates paclitaxel-induced intestinal barrier injury: Apoptosis inhibition by reversing microtubule polymerization

Cited by 41 publications

References 54 publications

Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Polysaccharides as Potential Anti-tumor Biomacromolecules —A Review

Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma

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