Polysaccharides from natural resources exhibit great potential in the treatment of ulcerative colitis: A review

Niu, Wei; Chen, Xiaoqing; Xu, Ruling; Dong, Hui-Min; Yang, Feng; Wang, Yun; Zhang, Zhenhai; Ju, Jianming

doi:10.1016/j.carbpol.2020.117189

Cited by 141 publications

(67 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A colite ulcerativa é uma doença inflamatória intestinal crônica e inespecífica que afeta o cólon e reto através da formação de úlceras na mucosa intestinal e submucosa (Batista, et al, 2020). De etiologia multifatorial, está intimamente relacionado à microbiota intestinal, distúrbios do sistema imunológico, fatores hereditários, ambientais e psicológicos (Niu, et al, 2021). As manifestações clinicas frequentes incluem urgência fecal, sangramento retal, abdominal dor, diarreia, febre, fadiga e perda de peso (Batista, et al, 2020), que podem evoluir com anemia, emagrecimento, hipoproteinemia, distúrbios hídricos e eletrolíticos (Niu, et al, 2021).…”

Section: Discussionunclassified

Polissacarídeos naturais como abordagem terapêutica experimental no trato gastrointestinal: uma revisão sistemática

Lima¹,

Filho²,

Mariano³

et al. 2021

RSD

View full text Add to dashboard Cite

O objetivo desse trabalho foi realizar uma análise sistemática da literatura acerca dos principais efeitos dos polissacarideos naturais extraídos de plantas e algas em modelos experimentais de distúrbios gastrointestinais (DGI). Esta revisão se concentra em avanços recentes em estudos experimentais com polissacarídeos naturais no tratamento de doença de refluxo gastroesofágico (DRGE), gastrite, colite e diarreia. Trata-se de uma pesquisa bibliográfica, com abordagem qualitativa, tendo em vista os procedimentos de análise e interpretação dos dados obtidos, realizada através de buscas nas bases de dados: Medical Literature Analysis and Retrievel System Online (Medline), Scientific Electronic Library Online (Scielo) e Biblioteca Nacional de Medicina dos Estados Unidos (PubMed), utilizando os descritores: gum, sulfated polysaccharide, polysaccharide, gastric damage, antidiarrheal, gastroesophageal reflux e colitis em diferentes combinações utilizando o operador booleano “and”. Os artigos incluídos no estudo foram somente os que estavam inclusos nas plataformas, sendo considerados artigos, teses e dissertações, incluídos e indexados no período entre 2011 e 2021, que tivessem como metodologia principal estudos experimentais, pré-clínicos em espectro de atividades in vitro e in vivo sobre os efeitos dos polissacarídeos naturais em modelos de distúrbios gastrointestinais. Os demais artigos que não se enquadravam nesses critérios foram excluídos, chegando a amostra final de 35 trabalhos. Os mecanismos e a efetividade dos polissacarídeos são apresentados e discutidos em detalhes. Em geral, por apresentarem propriedades anti-inflamatória, antioxidante, gastroprotetora e antidiarreica, com boa eficácia e segurança, os estudos sugerem que os polissacarídeos naturais são uma alternativa interessante para o desenvolvimento de terapias inovadoras para DGI.

show abstract

Section: Discussionunclassified

Polissacarídeos naturais como abordagem terapêutica experimental no trato gastrointestinal: uma revisão sistemática

Lima¹,

Filho²,

Mariano³

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…Among various environmental factors, diet plays an important role in the pathogenesis of UC [ 4 ]. Currently, aminosalicylic acid, corticosteroids, and immunosuppressive agents are prescribed to treat UC [ 5 ]. However, headaches, nasopharyngitis, systemic infections, and many other adverse reactions may occur in response to these treatments [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…These polysaccharides are thought to balance inflammatory factors, regulate intestinal flora, protect the intestinal mucosa, and regulate the immune system. Moreover, they have the advantage of being safe and effective, with few side-effects [ 5 ]. As a polysaccharide, β-glucan is formed by combining d -glucose molecules via β-glycosidic bonds, and it mainly exists in fungal and plant cell walls.…”

Section: Introductionmentioning

confidence: 99%

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

Chen

Tian

et al. 2021

Molecules

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), which significantly affects human health, has two primary presentations: Crohn’s disease and ulcerative colitis (UC). Highland barley is the most common food crop for Tibetans and contains much more β-glucan than any other crop. Highland barley β-glucan (HBBG) can relieve the gastrointestinal dysfunction and promote intestines health. This study aimed to evaluate whether HBBG can relieve UC in mice. A mouse model of UC was established by adding 2% dextran sulfate sodium (DSS) to drinking water for 1 week. UC was alleviated after the introduction of the HBBG diet, as indicated by reductions in the disease activity index (DAI) score, histopathological damage, and the concentration of colonic myeloperoxidase (MPO), along with an improvement in colonic atrophy. Furthermore, we found that HBBG can increase the relative transcriptional levels of genes encoding ZO-1, claudin-1, occludin, and mucin2 (MUC2), thereby reducing intestinal permeability. Additionally, HBBG maintained the balance of proinflammatory and anti-inflammatory cytokines and modulated the structure of the intestinal flora.

show abstract

“…Polysaccharides have received wide attention thanks to their effective biological activities and multiple molecular targets ( Muhamad et al, 2019 ; Cao et al, 2020 ; Mohammed et al, 2021 ). Studies have shown that polysaccharides have a variety of biological activities, such as anti-tumor, anti-oxidation, anti-radiation, anti-virus, and hypoglycemic effects ( Mu et al, 2021 ; Niu et al, 2021 ). The development and application of polysaccharides in Chinese herbal medicine have enriched the treatment methods of modern medicine.…”

Section: Introductionmentioning

confidence: 99%

Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects

Huang

Wang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to find new therapies and new drugs to replace the treatment of pulmonary fibrosis. In recent years, there have been a great number of research reports on the treatment of traditional Chinese medicine polysaccharides in various system fields. Among them, the treatment of PF has also gained extensive attention. This review summarized the source of polysaccharides, the drug activity of traditional Chinese medicine, and the protective effects on targets of Pulmonary fibrosis. We hope it can inspire researchers to design and develop polysaccharides, serving as a reference for potential clinical therapeutic drugs.

show abstract

Polysaccharides from natural resources exhibit great potential in the treatment of ulcerative colitis: A review

Cited by 141 publications

References 110 publications

Polissacarídeos naturais como abordagem terapêutica experimental no trato gastrointestinal: uma revisão sistemática

Polissacarídeos naturais como abordagem terapêutica experimental no trato gastrointestinal: uma revisão sistemática

β-Glucan Extracted from Highland Barley Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice

Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects

Contact Info

Product

Resources

About