Polysomnographic effects of thyroid hormones in primary myxedema

Ruíz-Primo, E; Jurado, José Luis Parra; Solís, H.; Maisterrena, J; Fernández-Guardiola, Augusto; Valverde-R, Carlos

doi:10.1016/0013-4694(82)90068-2

Cited by 21 publications

(8 citation statements)

References 10 publications

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“…Altered sleep patterns can induce changes in anterior pituitary hormone secretion (28). We found in NFMA patients that deficiencies in anterior pituitary hormones, especially secondary hypothyroidism, are associated with altered sleep patterns, which is in line with findings in patients with primary hypothyroidism (29). GH deficiency or ACTH deficiency did not specifically influence sleep patterns in our study patients, in line with reports on sleep in GH deficiency (30,31) or Addison's disease (32).…”

Section: Discussionsupporting

confidence: 92%

Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

Klaauw

Dekkers

Pereira

et al. 2007

The Journal of Clinical Endocrinology & Metabolism

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Section: Discussionsupporting

confidence: 92%

Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

Klaauw

Dekkers

Pereira

et al. 2007

The Journal of Clinical Endocrinology & Metabolism

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“…[43]–[44] The link with hypothyroidism is of particular interest considering that some hibernators are believed to decrease thyroid hormone production prior to and during hibernation, raising the possibility that some of the differences in findings related to hibernation in different species might reflect differences in thyroid levels during hibernation. [43] In this regard, it is possible that due to the low thyroid state, non-REM sleep was present during hibernation but we were unable to identify it due to the relative decrease in slow-wave amplitude that occurs when thyroid levels decrease [43].…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Sleep with Temperature and Metabolic Rate in a Hibernating Primate

et al. 2013

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Study ObjectivesIt has long been suspected that sleep is important for regulating body temperature and metabolic-rate. Hibernation, a state of acute hypothermia and reduced metabolic-rate, offers a promising system for investigating those relationships. Prior studies in hibernating ground squirrels report that, although sleep occurs during hibernation, it manifests only as non-REM sleep, and only at relatively high temperatures. In our study, we report data on sleep during hibernation in a lemuriform primate, Cheirogaleus medius. As the only primate known to experience prolonged periods of hibernation and as an inhabitant of more temperate climates than ground squirrels, this animal serves as an alternative model for exploring sleep temperature/metabolism relationships that may be uniquely relevant to understanding human physiology.Measurements and ResultsWe find that during hibernation, non-REM sleep is absent in Cheirogaleus. Rather, periods of REM sleep occur during periods of relatively high ambient temperature, a pattern opposite of that observed in ground squirrels. Like ground squirrels, however, EEG is marked by ultra-low voltage activity at relatively low metabolic-rates.ConclusionsThese findings confirm a sleep-temperature/metabolism link, though they also suggest that the relationship of sleep stage with temperature/metabolism is flexible and may differ across species or mammalian orders. The absence of non-REM sleep suggests that during hibernation in Cheirogaleus, like in the ground squirrel, the otherwise universal non-REM sleep homeostatic response is greatly curtailed or absent. Lastly, ultra-low voltage EEG appears to be a cross-species marker for extremely low metabolic-rate, and, as such, may be an attractive target for research on hibernation induction.

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“…Sleepiness is a well-known symptom in hypothyroidism [29]. Some studies [30,31] have shown a significant decrease in the deeper stages of sleep (stages 3 and 4) in untreated hypothyroid subjects. This might explain some of the patients' feeling of not getting enough sleep.…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms in Hypothyroid Disorder with some Observations on Biochemical Correlates

et al. 2001

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Lumbar punctures and ratings of depressive symptoms were done in hypothyroid patients before and during L-thyroxine therapy. Before treatment, the most prominent symptoms were concentration difficulties, lassitude, and reduced sexual interest. All patients suffered from sleep disturbances. Suicidal thoughts did not occur at all. Inner tension was negatively correlated with the anxiogenic cholecystokinin tetrapeptide (CCK-4) in the cerebrospinal fluid (CSF), while reduced sexual interest was negatively correlated with CSF tryptophan. Furthermore, failing memory correlated negatively with T3 as well as T4 in serum. A positive correlation was found between failing memory and serum TSH. All patients improved significantly during treatment. No biochemical correlates were found. In conclusion, hypothyroidism is associated with major depressive symptoms. CSF CCK-4 and tryptophan, as well as serum thyroid hormones, may constitute biochemical correlates for some of these symptoms.

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Polysomnographic effects of thyroid hormones in primary myxedema

Cited by 21 publications

References 10 publications

Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

Increased Daytime Somnolence despite Normal Sleep Patterns in Patients Treated for Nonfunctioning Pituitary Macroadenoma

The Relationship of Sleep with Temperature and Metabolic Rate in a Hibernating Primate

Depressive Symptoms in Hypothyroid Disorder with some Observations on Biochemical Correlates

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