Population-Based Study of Human Papillomavirus Infection and Cervical Neoplasia in Rural Costa Rica

Herrero, Rolando; Hildesheim, Allan; Bratte, Concepcion; Sherman, Mark E.; Hutchinson, Martha L.; Morales, Jorge; Balmaceda, Ileana; Greenberg, Mitchell; Alfaro, Mario; Burk, Robert D.; Wacholder, Sholom; Plummer, Martyn; Schiffman, Mark

doi:10.1097/00006254-200010000-00016

Cited by 113 publications

(195 citation statements)

References 34 publications

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“…The consistency of our findings with those of Munoz et al [1] is striking, given that these same four HPV types were found to have statistically significant differences by age. Our results of a higher prevalence of HPV 16 among younger high grade CIN cases are also consistent with results of 142 cases of CIN2 or greater from Costa Rica [22]. Differences of the prevalence of HPV types across age could reflect relative differences in the oncogenicity of different HPV types, or might reflect temporal changes in HPV patterns.…”

Section: Discussionsupporting

confidence: 89%

Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18

Chen

Zhang

Molijn

et al. 2009

Cancer Causes Control

104

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Prophylactic vaccination against HPV 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [CIN)] 2/3) and ICC caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. To provide data for decisions on HPV vaccination in China, we determined HPV type-distribution in ICC and CIN 2/3 from women of different regions within China. A multicenter study was conducted by randomized sampling of paraffin blocks of 664 ICC (630 squamous cell carcinoma [SCC]; 34 adenocarcinoma [ADC]), 569 CIN 2/3 cases from seven regions of China. Histological diagnosis was confirmed in 1,233 cases by consensus review. HPV DNA was detected using the SPF10 LiPA25 version 1 assay. HPV prevalence was 97.6% in SCC, 85.3% in adenocarcinoma, and 98.9% in CIN 2/3. HPV 16 (76.7%) and HPV 18 (7.8%) were the most common, together accounting for 84.5% of SCC, followed by HPV 31 (3.2%), HPV 52 (2.2%), and HPV 58 (2.2%). HPV positivity in SCC did not differ notably by region. However, SCC cases from women

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Section: Discussionsupporting

confidence: 89%

Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18

Chen

Zhang

Molijn

et al. 2009

Cancer Causes Control

104

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“…Furthermore, the risk of cervical cancer for the cervical HPV carriers was increased by 4 fold [15]. However, it has also been confirmed in other studies that there was no effect of oral contraceptives on HPV infection [2].…”

Section: Contraceptive Methodsmentioning

confidence: 64%

“…It has been indicated that HPV IR of women whose sexual partners used condoms was lower (9.4%) [14]. However, no evidence was found that the condom utilization cut down HPV IR in other studies, and the contact of genital duct skins between sexual partners was not avoided because the condom is merely a kind of physical barrier [2]. The dispute of the impact of oral contraceptives on HPV IR is still great.…”

Section: Contraceptive Methodsmentioning

confidence: 99%

Section: Hpv Infection Rate Of the Cervical Lesionsmentioning

confidence: 99%

“…The cervix HPV infection rate (IR) of women with normal results of cytological examination is 10.2%-40.0% [2][3][4], HPV IR for patients with atypical squamous cell of undetermined significance (ASCUS) was 20.0%-65.1% and 64.4%-90.9% for low grade squamous intraepithelial lesion (LGSIL), respectively. The high-risk HPV infection rate (HR-HPV IR) of patients with high-grade squamous intraepithelial lesion (HGSIL) was 73.3%-100.0% [2,3,5] and 88.4%-99.7% for patients with cervical cancer [2,5]. The examinations, including colposcopy, cervical biopsy, and HPV DNA detection were further applied for 314 women with abnormal cell smear results by Infantolino et al It was found that the cervical abnormal hyperplasia level, and the HR-HPV IR were strikingly increased.…”

Section: Hpv Infection Rate Of the Cervical Lesionsmentioning

confidence: 99%

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Clinical significance of human papilloma virus infection in the cervical lesions

Meng

et al. 2010

Front. Med. China

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Cervical lesions have been regarded as the common and frequently occurring diseases in China. Recently, the morbidity and youth tendency of cervical cancer have gradually increased. Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases threatening health and life of women, and is an infectious disease. The universality of HPV infection in the reproductive tract should not be ignored. The well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviors, immunosuppression, age, contraceptive methods, the concurrent infection of other sexually transmitted diseases, etc. The variation of cervical lesions induced by HPV infection is involved in the continuous pathological process, including the subclinical, latent, and persistent infection of high risk (HR)-HPV, chronic cervicitis with abnormal results of cytological examination, cervical intraepithelial neoplasia (CIN), and cervical cancer. The outcome of patients with HPV infection is influenced by many factors, such as HPV subtype dominance, persistent HPV infection, HPV loading dose, and multiple HPV infection. Controlling HR-HPV persistent infection should be an important strategy for reducing cervical lesions.

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Policy Analysis of Cervical Cancer Screening Strategies in Low-Resource Settings

Goldie¹,

Kuhn²,

Denny³

et al. 2001

JAMA

292

233

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Population-Based Study of Human Papillomavirus Infection and Cervical Neoplasia in Rural Costa Rica

Cited by 113 publications

References 34 publications

Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18

Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18

Clinical significance of human papilloma virus infection in the cervical lesions

Policy Analysis of Cervical Cancer Screening Strategies in Low-Resource Settings

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