Porphyromonas gingivalis Infection Accelerates Atherosclerosis Mediated by Oxidative Stress and Inflammatory Responses in ApoE-/- Mice

Xuan, Yue; Shi, Qiao; Liu, Guojing; Cai, Yu

doi:10.7754/clin.lab.2017.170410

Cited by 14 publications

(15 citation statements)

References 61 publications

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“…Similarly, hyperhomocysteinemic individuals have elevated LOX‐1 expression in peripheral blood mononuclear cells, while, after treatment with folic acid, LOX‐1 upregulation is normalized . Interestingly, infections caused by Chlamydophylia pneumoniae , Cytomegalovirus, Porphyromonas gingivalis , and Helicobacter pylori contribute to atherosclerosis . For example, when ECs were infected by C. pneumoniae , increased expression of LOX‐1 and LOX‐1‐mediated ox‐LDL endocytosis was observed in HUVECs.…”

Section: Regulation Of Lox‐1mentioning

confidence: 99%

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Tian

Ogura

Little

et al. 2018

Annals of the New York Academy of Sciences

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LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1; also known as OLR1) is the dominant receptor that recognizes and internalizes oxidized low-density lipoproteins (ox-LDLs) in endothelial cells. Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease. The LOX-1-ox-LDL interaction induces endothelial dysfunction, leukocyte adhesion, macrophage-derived foam cell formation, smooth muscle cell proliferation and migration, and platelet activation. LOX-1 activation eventually leads to the rupture of atherosclerotic plaques and acute cardiovascular events. In addition, LOX-1 can be cleaved to generate soluble LOX -1 (sLOX-1), which is a useful diagnostic and prognostic marker for atherosclerosis-related diseases in human patients. Of therapeutic relevance, several natural products and clinically used drugs have emerged as LOX-1 inhibitors that have antiatherosclerotic actions. We hereby provide an updated overview of role of LOX-1 in atherosclerosis and associated vascular diseases, with an aim to highlighting the potential of LOX-1 as a novel theranostic tool for cardiovascular disease prevention and treatment.

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Section: Regulation Of Lox‐1mentioning

confidence: 99%

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Tian

Ogura

Little

et al. 2018

Annals of the New York Academy of Sciences

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“…Unlike lipid‐lowering agents, DNJ also has the function of regulating immunity (Piao et al., 2018). Furthermore, pathogen infection may accelerate atherosclerosis caused by oxidative stress and inflammatory activities in an animal model (Xuan et al., 2017). DNJ exerts antioxidant and antibacterial activities (Tang et al., 2017), and which may be suitable for patients with atherosclerotic events.…”

Section: Discussionmentioning

confidence: 99%

Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial

Wang

Jiang

et al. 2020

J. Food Biochem.

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“…Atherosclerosis mainly occurs in the intimal layer of the blood vessel wall, and is characterized by subendothelial lipid deposits, vascular smooth muscle cell migration and proliferation, and formation of foam cells in the subendothelial space [ 83 ]. Risk factors for cardiovascular diseases include vascular senescence and obesity.…”

Section: Ahr As a Therapeutic Target In Cardiovascular Diseasesmentioning

confidence: 99%

Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases

Tao

Wang

Zhu

et al. 2018

BioMed Research International

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The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear receptor mediating xenobiotic metabolism and environmental responses. Owing to the evolutionary conservation of this gene and its widespread expression in the immune and circulatory systems, AhR has for many years been almost exclusively studied by the pharmacological/toxicological field for its role in contaminant toxicity. More recently, the functions of AhR in environmental adaption have been examined in the context of the occurrence, development, and therapy of cardiovascular diseases. Increasing evidence suggests that AhR is involved in maintaining homeostasis or in triggering pathogenesis by modulating the biological responses of critical cell types in the cardiovascular system. Here, we describe the structure, distribution, and ligands of AhR and the AhR signaling pathway and review the impact of AhR on cardiovascular physiology. We also discuss the potential contribution of AhR as a new potential factor in the targeted treatment of cardiovascular diseases.

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Porphyromonas gingivalis Infection Accelerates Atherosclerosis Mediated by Oxidative Stress and Inflammatory Responses in ApoE-/- Mice

Abstract: These results suggest that chronic intravenous infection with P. gingivalis in ApoE-/- mice could accelerate the development of atherosclerosis, possibly associated with mediating oxidative stress as well as inflammatory responses and disturbing the lipid profile.

Cited by 14 publications

References 61 publications

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Mulberry leaf attenuates atherosclerotic lesions in patients with coronary heart disease possibly via 1‐Deoxynojirimycin: A placebo‐controlled, double‐blind clinical trial

Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases

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