Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

Ceriello, Antonio

doi:10.2337/dc08-s245

Cited by 180 publications

(144 citation statements)

References 55 publications

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“…The animals were placed in heated chamber at an ambient temperature of (30)(31)(32)(33)(34) 曟 ) for 15 min and from each animal, [1][2][3][4][5][6][7][8][9] blood pressure values were recorded. The lowest three readings were averaged to obtain a mean blood pressure.…”

Section: Measurement Of Blood Pressure By Non-invasive Methodsmentioning

confidence: 99%

“…CVD has reached epidemic proportions in India [2] and is estimated to result in more than 3 million deaths each year [3] . Hypertension is a major risk factor for cardiovascular diseases and a large body of evidence suggests oxidative stress, an increase in the production of reactive oxygen species (ROS), as a strong underlying factor in hypertension [4,5] . Excessive ROS generation has been suggested to be involved in a variety of cardiovascular diseases including hypertension, inflammation in the cardiovascular system, cardiac hypertrophy, cardiomyopathies and ischemic heart disease [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study

Pichavaram

Kumar

Raja

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Measurement Of Blood Pressure By Non-invasive Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study

Pichavaram

Kumar

Raja

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Oxygen free radicals have been reported to play an important role in the pathogenesis of a number of cardiovascular diseases (CVDs) such as atherosclerosis, ischemia, hypertension, cardiomyopathy, cardiac hypertrophy and congestive heart failure by both in vivo and in vitro studies [31][32][33][34][35]. Potential sources of free radicals during ischemia and reperfusion have been identified in myocytes, vascular endothelium, and leukocytes.…”

Section: Oxidative Stress and Cardiovascular Diseasesmentioning

confidence: 99%

Free Radicals, Antioxidants and Disease

Sharma¹

2014

Biol Med (Aligarh)

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Living cells continually generate free radicals or reactive oxygen species (ROS) through the respiratory chain during energetic metabolism. ROS can either be harmful or play important physiological roles in our body. Besides being produced during normal cell metabolism there are numerous exogenous factors, such as irradiation by UV light, X-rays, gamma-rays, and atmospheric pollutants which may lead to generation of ROS. Human body has various intrinsic mechanisms to counteract oxidative stress by producing antioxidants, or through externally derived foods and/or supplements. However whenever there is excess of free radicals their accumulation in the body generates a phenomenon called oxidative stress. As we age, this oxidative and/or nitrosative damages elicit a number of late-onset diseases after ROS/RNS accumulate to certain levels. The ROS/RNS-mediated late-onset diseases can occur in any system of the body and may lead to clinical conditions such as cancer, arthritis arteriosclerosis, and neurodegenerative diseases. Oxidative stress is marked with expression of specific biomarkers whose specificity towards the various disease condition needs validation. In this review, we summarize the source, balance, maintenance and physiological functions of ROS, and its toxic mechanisms underlying a number of diseases and also the biomarkers implicated in selected human diseases.

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“…There are numerous evidences suggesting that oxidative stress plays an important role in the development of hypertension [7][8][9] . It is possible that decreased antioxidant activity such as, superoxide dismutase and catalase and reduced levels of reactive oxygen species scavengers such as, vitamins E, C and glutathione contribute to oxidative stress 9 of which there are many crosssectional studies showing that vitamin C status is inversely associated with blood pressure.…”

mentioning

confidence: 99%

“…It is possible that decreased antioxidant activity such as, superoxide dismutase and catalase and reduced levels of reactive oxygen species scavengers such as, vitamins E, C and glutathione contribute to oxidative stress 9 of which there are many crosssectional studies showing that vitamin C status is inversely associated with blood pressure. Although some, but not all clinical trials have shown lowering effect of vitamin C on the level of blood pressure, scientific evidence especially in the Asian population is small 10 .…”

mentioning

confidence: 99%

Effect of Vitamin C Supplementation on Blood Pressure Level in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

Shateri¹,

Keshavarz²,

Hosseini³

et al. 2016

Biosci., Biotech. Res. Asia

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Hypertension is one of the common problems in diabetic people. There are evidences suggesting that oxidative stress plays an important role in the development of hypertension. It is possible that decreased antioxidant activity levels of reactive oxygen species scavengers such as vitamin C contribute to decreasing oxidative stress. This study was aimed to investigate the effect of vitamin C on blood pressure in people with type 2 diabetes. The present randomized controlled trial study was conducted on 84 patients with type 2 diabetes undergoing hypertension in the Diabetes Research Center of Tehran University of Medical Sciences, Iran, in 2014. Samples were randomly divided into two groups of vitamin C (n = 42) and placebo (n = 42) on the basis of the random permuted block method. The intervention group was given chewable vitamin C supplements at a dose of 250 mg 4 times a day and the control group was given its placebo for 45 days. The blood pressure of two groups was measured at baseline and in the end of the study. Data were analyzed using SPSS 16 software. No significant differences were observed in the average weight and body mass index, waist and hip circumference and daily intake of energy and its component between the two groups at the beginning and the end of the study. The mean of systolic (129.6±24.4 in vitamin C group and 129±14.1 in placebo, P=0.89) and diastolic (77.2±12.6 in vitamin C group and 76.5±9.65 in placebo, P=0.77) blood pressure at baseline was not significant between the two groups, but at the end of the study, findings showed that there is a significant difference between systolic (121.6±24.4 in vitamin C group and 129.2±13.5 in placebo, P<0.0001) and diastolic (72.5±11 in vitamin C group and 77.4±9.2 in placebo, P<0.0001) blood pressure of two groups.Conclusion: According to the result of this study, the consumption of vitamin C supplement may cause a reduction in blood pressure in patients with type 2 diabetes mellitus. Therefore, in order to improve the health of these people, increasing intake of vitamin C is recommended.

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Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

Cited by 180 publications

References 55 publications

Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study

Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study

Free Radicals, Antioxidants and Disease

Effect of Vitamin C Supplementation on Blood Pressure Level in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

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