Potential antioxidant peptides produced from whey hydrolysis with an immobilized aspartic protease from Salpichroa origanifolia fruits

Rocha, Gabriela Fernanda; Kise, Francisco; Rosso, Adriana; Parisi, Mónica Graciela

doi:10.1016/j.foodchem.2017.05.112

Cited by 46 publications

(16 citation statements)

References 33 publications

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“…Estos incluyen quelación de iones metálicos pro-oxidantes 40 , captación de radicales libres, inhibición de la peroxidación de lípidos, inactivación de especies reactivas de oxígeno, así como la combinación de éstas 39 . Los péptidos con gran capacidad antioxidante se han caracterizado por presentar una masa molecular menor a 3 kDa 41 , por lo que el tamaño y la composición de los aminoácidos que conforman las secuencias peptídicas juegan un papel importante 42,43 . En este sentido, aminoácidos tales como fenilalanina, tirosina, triptófano e histidina actúan como queladores de iones metálicos; lisina dona átomos de hidrógeno y cisteína secuestra radicales libres 44 .…”

Section: Sistema Endócrinounclassified

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

et al. 2019

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proteínas del lactosuero las convierte en un sustrato ideal para la generación de péptidos con actividad biológica. La presente revisión tiene por objetivo analizar y discutir los efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero (PBDL) en la salud. Asimismo, este trabajo muestra detalladamente las estructuras químicas de las secuencias de los PBDL capaces de ejercer efectos favorables in vitro e in vivo e influir positivamente en los sistemas cardiovascular, endócrino e inmunológico. Sin embargo, las metodologías para generar PBDL de manera controlada, la dosificación y las concentraciones óptimas han sido poco exploradas. Por lo que es importante llevar a cabo investigación de frontera que permita avanzar el umbral del conocimiento vislumbrando la posibilidad de utilizar los PBDL como coadyuvantes en la prevención y tratamiento de enfermedades. Palabras clave: Beneficios a la salud; Péptidos bioactivos; Proteínas derivadas del lactosuero.

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Section: Sistema Endócrinounclassified

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

et al. 2019

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“…One of these actions is the antioxidant effect, which is able to inhibit or retard cell degradation, such as damage to lipids and membrane proteins and mutations in Deoxyribonucleic Acid (DNA), caused by molecules such as reactive oxygen species and reactive nitrogen species [6]. These substances are produced through physiological processes of the cell such as respiration and can also be produced after exposure to xenobiotics [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

First phytochemical study and biological activity of the leaves ethanolic extract from Cissus spinosa Cambess

Sinhorin

Godoy

Sinhorin

et al. 2020

Sci Med

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AIMS: The objective of this study was to identify the phytochemical profile and to evaluate the biological effects of the crude ethanolic extract (EE) and the ethanolic fraction (EF) of leaves of the species Cissus spinosa Cambess, after oxidative stress induced by cyclophosphamide (CP) in mice.METHODS: Phytochemical profile was performed detecting functional groups and, analysis of total flavonoids and phenols concentration, as well as the antiradical activity in EE and EF. The phytochemical characterization was done for the identification of flavonoids present in the leaves of the plant. In the biochemical tests, hematological parameters, glucose and total cholesterol dosages in plasma, enzymatic and non-enzymatic antioxidants and lipid damage marker were evaluated in different tissues (liver, kidney and heart), besides genotoxic and immunological analyzes. The animals received 15 days of treatment, via gavage, with EE (50 mg kg-1) or EF (50 mg kg-1) and on the 15th day, an intraperitoneal injection of CP (100 mg kg-1) or saline (0.9%). After 24 h the last treatment, the animals were anesthetized for blood withdrawal, sacrificed and removal of the organs.RESULTS: In the phytochemical analyzes, the presence of alkaloids, flavonoids and phenols was identified, the latter presented a higher concentration for EF. Eight flavonoids were identified - Rutin, Quercetin-3-β-D-glucoside, Quercitrin, Taxifolin, Quercetin, Canferol, Luteolin and Apigenin. In the biochemical analyzes, in general, EE showed a better antioxidant action against oxidative damages, hypoglycemic and antitilipemic action when comparing with EF, probably due to the synergism caused by flavonoids. It was observed the reduction and an increase of micronucleated polychromatic erythrocytes, due to the action of antioxidant compounds and alkaloids present in the plant, also considering the question of the seasonal period that directly interferes in the production of these compounds. In the immunological analysis, the extracts did not stimulate the spontaneous production of oxygen peroxide (H2O2) and nitric oxide (NO•). CONCLUSIONS: Other studies, such as the variation of the chemical composition of the plant by local seasonality, hypoglycemic and antilipemic action, should be carried out to better delineate the biological action present in this plant.

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“…[5][6][7] Currently, many researchers focus on developing functional foods to scavenge free radicals. [8][9][10] As ingredients to such functional foods, antioxidant peptides have received much attention. [11][12][13][14] Researchers have tried to nd antioxidant peptides from natural sources.…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of an antioxidant collagen peptide from skipjack tuna (Katsuwonus pelamis) bone

Ding

Zhang

et al. 2019

RSC Adv.

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Potential antioxidant peptides produced from whey hydrolysis with an immobilized aspartic protease from Salpichroa origanifolia fruits

Cited by 46 publications

References 33 publications

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

First phytochemical study and biological activity of the leaves ethanolic extract from Cissus spinosa Cambess

Isolation and identification of an antioxidant collagen peptide from skipjack tuna (Katsuwonus pelamis) bone

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