Potential Endophytic Microbes Selection for Antidiabetic Bioactive Compounds Production

Dompeipen,; Srikandace, Yoice; Suharso, Wahyudi P.; Cahyana, Herry; Simanjuntak, Partomuan

doi:10.3923/ajb.2011.465.471

Cited by 29 publications

(13 citation statements)

References 4 publications

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“…-dihydroxybut-3-enyl)-5H-furan-2-one (21) and (2E,4R)-2,4dimethylnon-2-enoic acid (22); seven phenolic derivatives: p-hydroxyphenyllactic acid (23), phenyllactic acid (24), p-hydroxybenzoic acid (25), p-hydroxybenzaldehyde (26), n-butyl-3,4dihydroxybenzoate (27), n-hexyl-3,4-dihydroxybenzoate (28) and n-octyl-3,4-dihydroxybenzoate (29); and the known compound (2E,4S)-2,4-dimethyloct-2-enoic acid (30) ( Figure 5) [102]. Extracts of solid cultures of Sporormiella minimoides (Sporormiaceae), isolated as an endophytic fungus from leaves Hintonia latiflora collected in Mexico, yielded five polyketides, 3,6-dimethoxy-8methyl-1H,6Hbenzo[de]isochromene-1,9-dione (31), 3-hydroxy-1,6,10-trimethoxy-8-methyl-1H,3Hbenzo[de]isochromen-9-one (32), 5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone (33), minimoidiones A (34) and B (35), along with four known compounds: corymbiferone (36), ziganein (37), brocaenol B (38) and preussochromone C (39) [103][104][105]. Two other compounds, 9S,11R(+)-ascosalitoxin (40) and vermelhotin (41), were also produced by endophytes from this plant [105,106].…”

Section: J Fungi 2020 6 X For Peer Review 3 Of 31mentioning

confidence: 99%

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Cruz

Silva

Hamerski

2020

JoF

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This review presents the chemical diversity and pharmacological properties of secondary metabolites produced by endophytic fungi associated with various genera of Rubiaceae. Several classes of natural products are described for these endophytes, although, this study highlights the importance of some metabolites, which are involved in antifungal, antibacterial, anti-protozoal activities; neurodegenerative diseases; cytotoxic activity; anti-inflammatory and antioxidant activity; and hyperglycemic control.

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Section: J Fungi 2020 6 X For Peer Review 3 Of 31mentioning

confidence: 99%

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Cruz

Silva

Hamerski

2020

JoF

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“…One such activity includes antidiabetic, scientific studies have expressed the secondary metabolites secreted from endosymbionts are reported to profound antidiabetic activity. According to study conducted by (Dompeipen et al 2011), 45 endosymbionts were screened for α glucosidase inhibitory activity from six medicinal plants of Indonesia. The results showed that seven endosymbionts were capable of expressing α glucosidase inhibitory activity.…”

Section: Antidiabeticmentioning

confidence: 99%

Siberian plants: untapped repertoire of bioactive endosymbionts

2018

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Endosymbionts are microbial plethora inhabiting all plant species and have been subject of interest among the scientific communities. These symbionts have gained tremendous interest in recent decades owing to their emerging biological roles. Plants inhabiting Siberian niches are one of the least studied among the plant diversity across the globe. Barcoding these plants can be interesting to reveal bioactive endosymbionts bearing myriad biological properties. With the globe being succumbing to various challenges like antimicrobial resistance, combating infectious diseases like HIV, tuberculosis, cancer and many genetic disorders. The microbial resource can address these challenges by secreting value added bioactive compounds bearing activities. Among the microbial consortium, one of the least targeted areas is endosymbionts which forms one of the superior repertoires of bioactive metabolites. Based on these facts and consideration, present review insights myriad roles of endosymbionts and makes the alarming call towards tapping Siberian plants for novel endosymbionts.

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“…The literature of endophytic fungi from S. mahagoni is still minimal. Dompeipen et al (2011) reported that the biomass of endophytic fungus from S. mahagoni rods has higher antioxidant activity when compared to biomass extract. Mutmainnah (2016) reported that endophytic fungi of S. mahagoni could be used as raw material to the medicine of diabetes mellitus, but the active compound of the product produced by endophytic fungi S. mahagoni has not been found.…”

Section: Introductionmentioning

confidence: 99%

Chemical compound isolated from antioxidant active extract of endophytic fungus Cladosporium tenuissimum in Swietenia mahagoni leaf stalks

et al. 2019

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Abstract. Fadhillah, Elfita, Muharni, Yohandini H, Widjajanti. 2019. Chemical compound isolated from antioxidant active extract of endophytic fungus Cladosporium tenuissimum in Swietenia mahagoni leaf stalks. Biodiversitas 20: 2645-2650. Swietenia mahagoni L. Jacq is a medicinal plant that widely used as an antimicrobial, anti-inflammatory, antimutagenic, anticancer, antitumor, and antidiabetic. Several bioactive compounds have been reported to be associated with this plant that supports its treatment activities. Flavonoid content of the S. mahagoni has antioxidant activity. Therefore the plant is widely used to treat degenerative diseases caused by free radical activity in the body. Scientists have proven that the medicinal plants have a symbiotic relationship with the number of microorganisms that can produce bioactive compounds. One of the symbiotic microorganisms is endophytic fungi believed to be associated with every plant on earth. In this paper, we report a secondary metabolite compound from endophytic fungi isolated from S. mahagoni. The endophytic fungi (DMG1-DMG4) were isolated from leaf stalks of S. mahagoni. Antioxidant activity of endophytic fungi extracts was tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The chemical compound from the active extract was isolated by the chromatographic method, and the structure was elucidated by spectroscopic methods including UV, IR, NMR 1D (1H-NMR and 13C-NMR), NMR 2D (HMQC and HMBC). Antioxidant activity test showed the endophytic fungus (DMG3) has the highest activity. The chemical compound from DMG3 was identified as 5-hydroxy-2-oxo-2H-piran-4-yl) methyl acetate). The phylogenetic method used to molecular analysis of DMG3 confirmed the fungus as Cladosporium tenuissimum.

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Potential Endophytic Microbes Selection for Antidiabetic Bioactive Compounds Production

Cited by 29 publications

References 4 publications

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

Siberian plants: untapped repertoire of bioactive endosymbionts

Chemical compound isolated from antioxidant active extract of endophytic fungus Cladosporium tenuissimum in Swietenia mahagoni leaf stalks

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