Potential roles of matrix metalloproteinases and characteristics of ovarian development in neonatal guinea pigs

Influences of non‐nutritive sweeteners on ovarian and uterine expression of T1R2 and T1R3 in peripubertal female guinea pigs

“…The low-dose or high-dose SS and RA were exposed to prepubertal female guinea pigs in our experiments; guinea pigs are a more reliable reproductive model compared with mice and rats, and share similarities with farm livestock in their prolonged fourstage estrous cycle (Li et al, 2015). According to a previous study, non-nutritive sweeteners (NNS) were designed to have an equivalent sweetness with a high-dose 7.5 mM SS or 2.5 mM RA (Jiang et al, 2018), as a maximum of 0.4% sodium saccharin is more acceptable to rodents than pure saccharin (Rehn, Onuma, Rooney, & Boakes, 2018), and the intake peak of rebaudioside A occurred at a concentration of 0.1% in rodents (Núñez Martínez, Argüelles Luis, Méndez, & Carmen, 2016).…”